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ING4 inhibitor of growth family member 4 [ Homo sapiens (human) ]

Gene ID: 51147, updated on 2-Nov-2024

Summary

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Official Symbol
ING4provided by HGNC
Official Full Name
inhibitor of growth family member 4provided by HGNC
Primary source
HGNC:HGNC:19423
See related
Ensembl:ENSG00000111653 MIM:608524; AllianceGenome:HGNC:19423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
my036; p29ING4
Summary
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 15.7), endometrium (RPKM 14.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ING4 in Genome Data Viewer
Location:
12p13.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6650301..6663119, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6660668..6673486, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6759467..6772285, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6729027-6729548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6729549-6730069 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5872 Neighboring gene acrosin binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6756019-6756532 Neighboring gene MPRA-validated peak1551 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5874 Neighboring gene zinc finger protein 384 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:6798393-6799019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6808761-6809262 Neighboring gene PILR alpha associated neural protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition. Qu H, et al. Oncol Rep, 2016 May. PMID 26936485
  2. A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis. Kim S, et al. Cancer Res, 2010 Jun 15. PMID 20501848, Free PMC Article
  3. Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo. Li Z, et al. Cancer Biother Radiopharm, 2010 Aug. PMID 20707719
  4. Down-regulation of ING4 is associated with initiation and progression of lung cancer. Wang QS, et al. Histopathology, 2010 Aug. PMID 20716169, Free PMC Article
  5. The tumor suppressor inhibitor of growth 4 binds double-stranded DNA through its disordered central region. Ormaza G, et al. FEBS Lett, 2017 Jan. PMID 27926782

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).
    Title: Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2).
  2. ING4 Expression Landscape and Association With Clinicopathologic Characteristics in Breast Cancer.
    Title: ING4 Expression Landscape and Association With Clinicopathologic Characteristics in Breast Cancer.
  3. ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
    Title: ING3 and ING4 immunoexpression and their relation to the development of benign odontogenic lesions.
  4. [Expression levels of MMP-14, ING4 and HIF-1alpha in 60 patients with oral squamous cell carcinoma and their clinical significance].
    Title: [Expression levels of MMP-14, ING4 and HIF-1α in 60 patients with oral squamous cell carcinoma and their clinical significance].
  5. Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark.
    Title: Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark.
  6. Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis.
    Title: Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis.
  7. Low ING4 expression is associated with cell proliferation and migration of renal cell carcinoma .
    Title: Inhibitor of growth 4 inhibits cell proliferation, migration, and induces apoptosis of renal cell carcinoma cells.
  8. Found antibodies binding to p29ING4.
    Title: Autoantibodies against P29ING4 are associated with complex regional pain syndrome.
  9. differential expression profile revealed the potential role of ING4 in prostate cancer pathogenesis possibly through modulation of key genes, pathways and biological networks that are central drivers of the disease.
    Title: Identification of the inhibitor of growth protein 4 (ING4) as a potential target in prostate cancer therapy.
  10. These findings suggest that ING4 may inhibit hypoxia-induced EMT via decreasing HIF-1alpha and snail in HK2 cells, indicating the potential of ING4 as a therapeutic target for renal fibrosis.
    Title: Inhibitor of growth 4 (ING4) inhibits hypoxia-induced EMT by decreasing HIF-1α and snail in HK2 cells.
Submit: New GeneRIF Correction See all GeneRIFs (82)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12557

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K12 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT contributes_to histone H4K16 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K5 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K8 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of growth protein 4
Names
brain my036 protein
candidate tumor suppressor p33 ING1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047151.1 RefSeqGene

    Range
    5031..17849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127582.2 → NP_001121054.1  inhibitor of growth protein 4 isoform 9

    See identical proteins and their annotated locations for NP_001121054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents the longest transcript and it encodes the longest protein (isoform 9). Another name for this variant is ING4_v1.
    Source sequence(s)
    AC135892, AF156552, AW614868, BP303219
    Consensus CDS
    CCDS44813.1
    UniProtKB/Swiss-Prot
    A4KYM4, A4KYM6, D3DUR8, Q0EF62, Q0EF63, Q4VBQ6, Q96E15, Q9H3J0, Q9UNL4
    Related
    ENSP00000380024.4, ENST00000396807.8
    Conserved Domains (2) summary
    COG5034
    Location:7 → 245
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

  2. NM_001127583.2 → NP_001121055.1  inhibitor of growth protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001121055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 3) is shorter by 3 aa compared to isoform 9. Other names for this variant are ING4_v3 and "9 bp skip variant".
    Source sequence(s)
    AB197696, AC135892, AF156552, AW614868, BP303219
    Consensus CDS
    CCDS44814.1
    UniProtKB/TrEMBL
    B4DDF2
    Related
    ENSP00000412705.2, ENST00000412586.6
    Conserved Domains (2) summary
    COG5034
    Location:7 → 242
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

  3. NM_001127584.2 → NP_001121056.1  inhibitor of growth protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001121056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 4) is shorter by 4 aa compared to isoform 9. Other names for this variant are ING4_v4 and "12 bp skip variant".
    Source sequence(s)
    AB197697, AC135892, AF156552, AW614868, BP303219
    Consensus CDS
    CCDS44815.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000415903.2, ENST00000446105.6
    Conserved Domains (2) summary
    COG5034
    Location:7 → 241
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

  4. NM_001127585.2 → NP_001121057.1  inhibitor of growth protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001121057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate segment in the coding region, compared to variant 9. The resulting protein (isoform 5) is shorter when it is compared to isoform 9. Another name for this variant is delta Ex2.
    Source sequence(s)
    AC135892, AF156552, AW614868, BP303219, EF152349
    Consensus CDS
    CCDS44812.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000397343.2, ENST00000444704.5
    Conserved Domains (2) summary
    cd15684
    Location:173 → 220
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    cl28919
    Location:7 → 80
    ING; Inhibitor of growth (ING) domain family

  5. NM_001127586.2 → NP_001121058.1  inhibitor of growth protein 4 isoform 6

    See identical proteins and their annotated locations for NP_001121058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate segment in the 3' coding region. which changes the reading frame, compared to variant 9. The resulting protein (isoform 6) is shorter and has a distinct C-terminus when it is compared to isoform 9. Another name for this variant is delta Ex6A.
    Source sequence(s)
    AC135892, AF156552, AW614868, BP303219, EF152351
    Consensus CDS
    CCDS44816.1
    Related
    ENSP00000414008.2, ENST00000423703.6
    Conserved Domains (1) summary
    pfam12998
    Location:6 → 105
    ING; Inhibitor of growth proteins N-terminal histone-binding

  6. NM_016162.4 → NP_057246.2  inhibitor of growth protein 4 isoform 1

    See identical proteins and their annotated locations for NP_057246.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 1) is shorter by 1 aa compared to isoform 9. Other names for this variant are ING4_v2 and "3 bp skip variant".
    Source sequence(s)
    AC135892, AW614868, BC095434, BP303219
    Consensus CDS
    CCDS8555.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000343396.4, ENST00000341550.9
    Conserved Domains (2) summary
    COG5034
    Location:7 → 244
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11 → 104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6650301..6663119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428931.1 → XP_047284887.1  inhibitor of growth protein 4 isoform X2

  2. XM_011520964.3 → XP_011519266.1  inhibitor of growth protein 4 isoform X1

    Conserved Domains (2) summary
    cd15684
    Location:172 → 219
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    cl28919
    Location:7 → 80
    ING; Inhibitor of growth (ING) domain family

  3. XM_011520965.4 → XP_011519267.1  inhibitor of growth protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011519267.1

    Conserved Domains (2) summary
    cd15684
    Location:170 → 217
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    cl28919
    Location:1 → 77
    ING; Inhibitor of growth (ING) domain family

  4. XM_047428932.1 → XP_047284888.1  inhibitor of growth protein 4 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6660668..6673486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372181.1 → XP_054228156.1  inhibitor of growth protein 4 isoform X2

  2. XM_054372180.1 → XP_054228155.1  inhibitor of growth protein 4 isoform X1

  3. XM_054372182.1 → XP_054228157.1  inhibitor of growth protein 4 isoform X3

  4. XM_054372183.1 → XP_054228158.1  inhibitor of growth protein 4 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198287.1: Suppressed sequence

    Description
    NM_198287.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UNL4.1 GenPept UniProtKB/Swiss-Prot:Q9UNL4

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