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JPT1 Jupiter microtubule associated homolog 1 [ Homo sapiens (human) ]

Gene ID: 51155, updated on 7-Apr-2024

Summary

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Official Symbol
JPT1provided by HGNC
Official Full Name
Jupiter microtubule associated homolog 1provided by HGNC
Primary source
HGNC:HGNC:14569
See related
Ensembl:ENSG00000189159 MIM:619242; AllianceGenome:HGNC:14569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HN1; ARM2; HN1A
Summary
Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 36.4), colon (RPKM 19.4) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
17q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75135243..75154512, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76026703..76045989, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73131338..73150607, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089299-73089872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089873-73090445 Neighboring gene solute carrier family 16 member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73100784-73101284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73101285-73101785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73110035-73110574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12735 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:73120068-73121267 Neighboring gene armadillo repeat containing 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12736 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73126856-73127060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8956 Neighboring gene uncharacterized LOC107985034 Neighboring gene 5', 3'-nucleotidase, cytosolic Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73143638-73144837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8957 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73151095-73151690 Neighboring gene small ubiquitin like modifier 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73178362-73179012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73200579-73201513 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73201514-73202447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73203873-73204440 Neighboring gene nucleoporin 85 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73220785-73221286 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73221550-73222749 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73230746-73230909

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1. Peng J, et al. Comput Math Methods Med, 2023. PMID 36756386, Free PMC Article
  2. HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-κB signaling activation in cervical carcinoma. Chen J, et al. Biochem Biophys Res Commun, 2020 Sep 10. PMID 32828320
  3. HN1 as a diagnostic and prognostic biomarker for liver cancer. Liu Z, et al. Biosci Rep, 2020 Jul 31. PMID 32700728, Free PMC Article
  4. Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers. Bateman NW, et al. Cancer Med, 2020 Feb. PMID 31808620, Free PMC Article
  5. HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells. Varisli L, et al. J Cell Biochem, 2015 Jan. PMID 25169422

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hematological and neurological expressed 1 (HN1) activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of c-Myc in hepatocellular carcinoma.
    Title: Hematological and neurological expressed 1 (HN1) activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of c-Myc in hepatocellular carcinoma.
  2. Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1.
    Title: Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1.
  3. LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
    Title: LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.
  4. Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.
    Title: Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.
  5. HN1 as a diagnostic and prognostic biomarker for liver cancer.
    Title: HN1 as a diagnostic and prognostic biomarker for liver cancer.
  6. HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-kappaB signaling activation in cervical carcinoma.
    Title: HN1 promotes tumor associated lymphangiogenesis and lymph node metastasis via NF-κB signaling activation in cervical carcinoma.
  7. HNRNPA1-mediated alternative polyadenylation of HN1 contributes to cancer- and senescence-related phenotypes.
    Title: HNRNPA1-mediated 3' UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes.
  8. Downregulation of MYC abrogated the effect of HN1 overexpression in breast cancer cell lines. Taken together, these data reveal that HN1 promotes the progression of breast cancer by upregulating MYC expression, and might be a therapeutic target for breast cancer.
    Title: HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity.
  9. Data report that HN1 is an essential factor for beta-catenin turnover and signaling, augments cell growth and migration in prostate cancer cells.
    Title: HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells.
  10. miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3' UTR of HN1.
    Title: MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
jupiter microtubule associated homolog 1
Names
androgen-regulated protein 2
hematological and neurological expressed 1 protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002032.3 → NP_001002032.1  jupiter microtubule associated homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001002032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AF086910, AY322169
    Consensus CDS
    CCDS32729.1
    UniProtKB/Swiss-Prot
    Q9UK76
    Related
    ENSP00000348316.4, ENST00000356033.8
    Conserved Domains (1) summary
    pfam17054
    Location:1 → 58
    JUPITER; Microtubule-Associated protein Jupiter

  2. NM_001002033.3 → NP_001002033.1  jupiter microtubule associated homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001002033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 2. Variants 3, 5 and 6 encode the same isoform (3), which is shorter and has distinct N- and C-termini, compared to isoform 2.
    Source sequence(s)
    AF086910, AY322170
    Consensus CDS
    CCDS45772.1
    UniProtKB/Swiss-Prot
    Q9UK76

  3. NM_001288609.1 → NP_001275538.1  jupiter microtubule associated homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001275538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 2. Variants 3, 5 and 6 encode the same isoform (3), which is shorter and has distinct N- and C-termini, compared to isoform 2.
    Source sequence(s)
    AF086910, AW675726, BC039343, DB451153
    Consensus CDS
    CCDS45772.1
    UniProtKB/Swiss-Prot
    Q9UK76
    Related
    ENSP00000464266.1, ENST00000476258.5

  4. NM_001288610.1 → NP_001275539.1  jupiter microtubule associated homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001275539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 2. Variants 3, 5 and 6 encode the same isoform (3), which is shorter and has distinct N- and C-termini, compared to isoform 2.
    Source sequence(s)
    AF086910, AK308253, AW675726
    Consensus CDS
    CCDS45772.1
    UniProtKB/Swiss-Prot
    Q9UK76
    Related
    ENSP00000462834.1, ENST00000482348.5

  5. NM_001288611.2 → NP_001275540.1  jupiter microtubule associated homolog 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 2. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC022211, AF086910, BG779109
    UniProtKB/TrEMBL
    J3KT51
    Conserved Domains (1) summary
    pfam17054
    Location:1 → 58
    JUPITER; Microtubule-Associated protein Jupiter

  6. NM_016185.4 → NP_057269.1  jupiter microtubule associated homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_057269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AF266846, AW675726
    Consensus CDS
    CCDS45771.1
    UniProtKB/Swiss-Prot
    B2R6K3, Q53FG7, Q7Z2D2, Q7Z2F0, Q9UK76
    Related
    ENSP00000387059.3, ENST00000409753.8
    Conserved Domains (1) summary
    pfam17054
    Location:1 → 58
    JUPITER; Microtubule-Associated protein Jupiter

RNA

  1. NR_109933.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in an internal exon and contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF086910, DA604735

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75135243..75154512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450779.2 → XP_024306547.1  jupiter microtubule associated homolog 1 isoform X1

    Related
    ENSP00000462478.1, ENST00000481647.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76026703..76045989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK76.3 GenPept UniProtKB/Swiss-Prot:Q9UK76

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