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ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 51304, updated on 3-Nov-2024

Summary

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Official Symbol
ZDHHC3provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:18470
See related
Ensembl:ENSG00000163812 MIM:617150; AllianceGenome:HGNC:18470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GODZ; DHHC3; DHHC-3; ZNF373
Summary
Enables palmitoyltransferase activity. Involved in several processes, including protein localization to membrane; protein localization to photoreceptor outer segment; and regulation of signal transduction. Located in membrane. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 9.5), skin (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ZDHHC3 in Genome Data Viewer
Location:
3p21.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44915261..44976174, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44930989..44991916, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44956753..45017666, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44925386-44926063 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene transglutaminase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44940040-44940581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44975255-44976082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44981025-44981526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44981527-44982026 Neighboring gene ribosomal protein L12 pseudogene 44 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:45000471-45001670 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:45016646-45017190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14276 Neighboring gene exosome component 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068175-45068676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068677-45069176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45075939-45076588 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural Exploration on Palmitoyltransferase DHHC3 from Homo sapiens. Tang M, et al. Polymers (Basel), 2022 Jul 26. PMID 35893977, Free PMC Article
  2. Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. Sharma C, et al. Cancer Res, 2017 Dec 15. PMID 29055014, Free PMC Article
  3. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4. Sharma C, et al. Cell Mol Life Sci, 2012 Jul. PMID 22314500, Free PMC Article
  4. Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Sharma C, et al. Cell Mol Life Sci, 2021 Mar. PMID 32986127, Free PMC Article
  5. zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma. Zhang X, et al. J Cancer Res Clin Oncol, 2024 Apr 15. PMID 38619631, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma.
    Title: zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma.
  2. IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption.
    Title: IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption.
  3. Antioxidant functions of DHHC3 suppress anti-cancer drug activities.
    Title: Antioxidant functions of DHHC3 suppress anti-cancer drug activities.
  4. DHHC3-mediated protein palmitoylation supports breast tumor growth by modulating cellular oxidative stress and senescence.
    Title: Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence.
  5. HSV-1 UL20 binds to GODZ (also known as DHHC3), a Golgi apparatus-specific Asp-His-His-Cys (DHHC) zinc finger protein. a GODZ dominant-negative mutant and an inhibitor of palmitoylation reduced HSV-1 titers and altered the localization of UL20 and glycoprotein K. UL20 is palmitoylated by GODZ, and this UL20 palmitoylation is required for HSV-1 infectivity.
    Title: Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.
  6. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
  7. GODZ regulates plasma membrane targeting of DR4 and thus TRAIL/DR4-mediated apoptosis in cancer cells.
    Title: Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells.
  8. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4.
    Title: Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4.
  9. Data conclude that GODZ encodes a Ca(2+) transport protein in addition to its ability to palmitoylate protein substrates.
    Title: Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20209, FLJ45940, DKFZp313D2314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-cysteine S-palmitoyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TRAIL-activated apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipoprotein localization to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of toll-like receptor 9 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to membrane TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein localization to photoreceptor outer segment IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
palmitoyltransferase ZDHHC3
Names
DHHC1 protein
Golgi apparatus-specific protein with DHHC zinc finger domain
acyltransferase ZDHHC3
golgi-specific DHHC Zinc Finger Protein
zinc finger DHHC domain-containing protein 3
zinc finger DHHC-type containing 3
zinc finger protein 373
zinc finger, DHHC domain containing 3
NP_001128651.1
NP_001317690.1
NP_001336305.1
NP_001336306.1
NP_001336307.1
NP_001336308.1
NP_001336309.1
NP_001336310.1
NP_057682.1
XP_016862050.1
XP_016862051.1
XP_016862057.1
XP_024309326.2
XP_024309327.2
XP_047304216.1
XP_047304217.1
XP_047304218.1
XP_047304219.1
XP_047304220.1
XP_047304221.1
XP_047304222.1
XP_047304224.1
XP_047304225.1
XP_047304226.1
XP_047304227.1
XP_054202729.1
XP_054202730.1
XP_054202731.1
XP_054202732.1
XP_054202733.1
XP_054202734.1
XP_054202735.1
XP_054202736.1
XP_054202737.1
XP_054202738.1
XP_054202739.1
XP_054202740.1
XP_054202741.1
XP_054202742.1
XP_054202743.1
XP_054202744.1
XP_054202745.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135179.2 → NP_001128651.1  palmitoyltransferase ZDHHC3 isoform 1

    See identical proteins and their annotated locations for NP_001128651.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 9 and 10, encodes isoform 1.
    Source sequence(s)
    AA778122, AC098649, AC104165, AK000216, BC015467, DB636483
    Consensus CDS
    CCDS46811.1
    UniProtKB/Swiss-Prot
    Q53A17, Q96BL0, Q9NYG2
    Related
    ENSP00000395502.2, ENST00000424952.7
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 255
    DHHC; DHHC palmitoyltransferase

  2. NM_001330761.2 → NP_001317690.1  palmitoyltransferase ZDHHC3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes isoform 4.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS87071.1
    UniProtKB/TrEMBL
    F8W6M3
    Related
    ENSP00000345268.4, ENST00000342790.8
    Conserved Domains (1) summary
    pfam01529
    Location:162 → 289
    DHHC; DHHC palmitoyltransferase

  3. NM_001349376.2 → NP_001336305.1  palmitoyltransferase ZDHHC3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS93256.1
    UniProtKB/TrEMBL
    A0A994J7J2
    Related
    ENSP00000516198.1, ENST00000705994.1
    Conserved Domains (2) summary
    pfam01529
    Location:128 → 283
    zf-DHHC; DHHC palmitoyltransferase
    cl19890
    Location:52 → 194
    zf-DHHC; DHHC palmitoyltransferase

  4. NM_001349377.2 → NP_001336306.1  palmitoyltransferase ZDHHC3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform 6.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46810.1
    UniProtKB/TrEMBL
    H0Y6A5
    Related
    ENSP00000404108.2, ENST00000339420.7
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 255
    zf-DHHC; DHHC palmitoyltransferase

  5. NM_001349378.2 → NP_001336307.1  palmitoyltransferase ZDHHC3 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 7.
    Source sequence(s)
    AC098649, AC104165
    Conserved Domains (1) summary
    pfam01529
    Location:54 → 209
    zf-DHHC; DHHC palmitoyltransferase

  6. NM_001349379.2 → NP_001336308.1  palmitoyltransferase ZDHHC3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform 8.
    Source sequence(s)
    AC098649, AC104165
    Conserved Domains (1) summary
    pfam01529
    Location:54 → 181
    DHHC; DHHC palmitoyltransferase

  7. NM_001349380.2 → NP_001336309.1  palmitoyltransferase ZDHHC3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1 and 10, encodes isoform 1.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46811.1
    UniProtKB/Swiss-Prot
    Q53A17, Q96BL0, Q9NYG2
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 255
    DHHC; DHHC palmitoyltransferase

  8. NM_001349381.2 → NP_001336310.1  palmitoyltransferase ZDHHC3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1 and 9, encodes isoform 1.
    Source sequence(s)
    AC098649, AC104165
    Consensus CDS
    CCDS46811.1
    UniProtKB/Swiss-Prot
    Q53A17, Q96BL0, Q9NYG2
    Conserved Domains (1) summary
    pfam01529
    Location:128 → 255
    DHHC; DHHC palmitoyltransferase

  9. NM_016598.3 → NP_057682.1  palmitoyltransferase ZDHHC3 isoform 2

    See identical proteins and their annotated locations for NP_057682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AA778122, AC098649, AC104165, AF247703, AK000216, DB636483
    Consensus CDS
    CCDS2724.1
    UniProtKB/Swiss-Prot
    Q9NYG2
    Related
    ENSP00000296127.3, ENST00000296127.7
    Conserved Domains (2) summary
    pfam01529
    Location:129 → 283
    zf-DHHC; DHHC palmitoyltransferase
    cl19890
    Location:52 → 194
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. NR_146161.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165

  2. NR_146162.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165

  3. NR_146163.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098649, AC104165

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44915261..44976174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006562.2 → XP_016862051.1  palmitoyltransferase ZDHHC3 isoform X6

  2. XM_017006561.2 → XP_016862050.1  palmitoyltransferase ZDHHC3 isoform X4

  3. XM_047448265.1 → XP_047304221.1  palmitoyltransferase ZDHHC3 isoform X5

  4. XM_047448264.1 → XP_047304220.1  palmitoyltransferase ZDHHC3 isoform X3

  5. XM_047448263.1 → XP_047304219.1  palmitoyltransferase ZDHHC3 isoform X2

  6. XM_047448260.1 → XP_047304216.1  palmitoyltransferase ZDHHC3 isoform X1

  7. XM_047448266.1 → XP_047304222.1  palmitoyltransferase ZDHHC3 isoform X14

    UniProtKB/TrEMBL
    A0A994J7J2

  8. XM_047448261.1 → XP_047304217.1  palmitoyltransferase ZDHHC3 isoform X1

  9. XM_047448262.1 → XP_047304218.1  palmitoyltransferase ZDHHC3 isoform X1

  10. XM_017006568.1 → XP_016862057.1  palmitoyltransferase ZDHHC3 isoform X13

  11. XM_047448268.1 → XP_047304224.1  palmitoyltransferase ZDHHC3 isoform X9

  12. XM_024453558.2 → XP_024309326.2  palmitoyltransferase ZDHHC3 isoform X7

  13. XM_047448271.1 → XP_047304227.1  palmitoyltransferase ZDHHC3 isoform X12

  14. XM_047448270.1 → XP_047304226.1  palmitoyltransferase ZDHHC3 isoform X11

  15. XM_047448269.1 → XP_047304225.1  palmitoyltransferase ZDHHC3 isoform X10

  16. XM_024453559.2 → XP_024309327.2  palmitoyltransferase ZDHHC3 isoform X8

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    440611..451168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44930989..44991916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346762.1 → XP_054202737.1  palmitoyltransferase ZDHHC3 isoform X6

  2. XM_054346759.1 → XP_054202734.1  palmitoyltransferase ZDHHC3 isoform X4

  3. XM_054346760.1 → XP_054202735.1  palmitoyltransferase ZDHHC3 isoform X5

  4. XM_054346758.1 → XP_054202733.1  palmitoyltransferase ZDHHC3 isoform X3

  5. XM_054346757.1 → XP_054202732.1  palmitoyltransferase ZDHHC3 isoform X2

  6. XM_054346754.1 → XP_054202729.1  palmitoyltransferase ZDHHC3 isoform X1

  7. XM_054346763.1 → XP_054202738.1  palmitoyltransferase ZDHHC3 isoform X14

    UniProtKB/TrEMBL
    H0Y6A5

  8. XM_054346761.1 → XP_054202736.1  palmitoyltransferase ZDHHC3 isoform X14

    UniProtKB/TrEMBL
    A0A994J7J2

  9. XM_054346755.1 → XP_054202730.1  palmitoyltransferase ZDHHC3 isoform X1

  10. XM_054346756.1 → XP_054202731.1  palmitoyltransferase ZDHHC3 isoform X1

  11. XM_054346770.1 → XP_054202745.1  palmitoyltransferase ZDHHC3 isoform X13

  12. XM_054346766.1 → XP_054202741.1  palmitoyltransferase ZDHHC3 isoform X9

  13. XM_054346764.1 → XP_054202739.1  palmitoyltransferase ZDHHC3 isoform X7

  14. XM_054346769.1 → XP_054202744.1  palmitoyltransferase ZDHHC3 isoform X12

  15. XM_054346768.1 → XP_054202743.1  palmitoyltransferase ZDHHC3 isoform X11

  16. XM_054346767.1 → XP_054202742.1  palmitoyltransferase ZDHHC3 isoform X10

  17. XM_054346765.1 → XP_054202740.1  palmitoyltransferase ZDHHC3 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135180.1: Suppressed sequence

    Description
    NM_001135180.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYG2.2 GenPept UniProtKB/Swiss-Prot:Q9NYG2

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