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PLA1A phospholipase A1 member A [ Homo sapiens (human) ]

Gene ID: 51365, updated on 2-Nov-2024

Summary

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Official Symbol
PLA1Aprovided by HGNC
Official Full Name
phospholipase A1 member Aprovided by HGNC
Primary source
HGNC:HGNC:17661
See related
Ensembl:ENSG00000144837 MIM:607460; AllianceGenome:HGNC:17661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSPLA1; PS-PLA1
Summary
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Expression
Broad expression in liver (RPKM 8.5), lymph node (RPKM 6.1) and 17 other tissues See more
Orthologs
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Genomic context

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See PLA1A in Genome Data Viewer
Location:
3q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (119597885..119629811)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (122317610..122349514)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119316732..119348658)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:119287249-119287750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:119297943-119298444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20314 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:119300593-119301792 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:119319749-119320248 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:119331548-119331710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20319 Neighboring gene ribosomal protein L10 pseudogene 7 Neighboring gene popeye domain cAMP effector 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Analysis of glycero-lysophospholipids in gastric cancerous ascites. Emoto S, et al. J Lipid Res, 2017 Apr. PMID 28143894, Free PMC Article
  2. Expression of phosphatidylserine-specific phospholipase A(1) mRNA in human THP-1-derived macrophages. Hosono H, et al. Cell Transplant, 2010. PMID 20573295
  3. Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 ( PSPLA1). Wang J, et al. J Hum Genet, 2002. PMID 12436198
  4. Structure and function of phosphatidylserine-specific phospholipase A1. Aoki J, et al. Biochim Biophys Acta, 2002 May 23. PMID 12069807
  5. An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans. Nagai Y, et al. J Biol Chem, 1999 Apr 16. PMID 10196188

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphatidylserine-Specific Phospholipase A1 Limits Aggressiveness of Lung Adenocarcinoma by Lysophosphatidylserine and Protein Kinase A-Dependent Pathway.
    Title: Phosphatidylserine-Specific Phospholipase A1 Limits Aggressiveness of Lung Adenocarcinoma by Lysophosphatidylserine and Protein Kinase A-Dependent Pathway.
  2. Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis.
    Title: Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis.
  3. PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer.
    Title: PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer.
  4. Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma.
    Title: Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma.
  5. Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.
    Title: Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.
  6. Serum PS-PLA1 is associated with disease activity of systemic lupus erythematosus, indicating its possible use as a biomarker for monitoring SLE disease activity.
    Title: Serum phosphatidylserine-specific phospholipase A(1) as a novel biomarker for monitoring systemic lupus erythematosus disease activity.
  7. PLA1A interacts with hepatitis C virus E2, NS2 and NS5A via multiple interaction sites, which is important for HCV assembly
    Title: Phosphatidylserine-Specific Phospholipase A1 is the Critical Bridge for Hepatitis C Virus Assembly.
  8. this report identified PLA1A as a host factor that modulates the TBK1 activation during antiviral innate immune response
    Title: PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
  9. Serum PS-PLA1 levels were significantly higher in the melanoma subjects and associated with the clinical stages.
    Title: Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma.
  10. the LysoPA levels might be determined largely by LysoPC and LysoPI (possible precursors) and the PS-PLA1-mediated pathway might be involved in the production of LysoPS in gastric cancer.
    Title: Analysis of glycero-lysophospholipids in gastric cancerous ascites.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of phospholipase A1 member A (PLA1A) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase A1 member A (PLA1A) in primary human brain microvascular endothelial cells PubMed
tat HIV-1 Tat upregulates phospholipase A1 member A (PLA1A) expression in Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylserine 1-acylhydrolase activity TAS
Traceable Author Statement
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phosphatidylserine metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipase A1 member A
Names
phosphatidylserine-specific phospholipase A1alpha
NP_001193889.1
NP_001193890.1
NP_001280154.1
NP_056984.1
XP_016862061.1
XP_054202750.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029696.1 RefSeqGene

    Range
    5011..36937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206960.2 → NP_001193889.1  phospholipase A1 member A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC035347, BC047703, DB189568
    Consensus CDS
    CCDS56268.1
    UniProtKB/Swiss-Prot
    Q53H76
    Related
    ENSP00000417326.1, ENST00000495992.5
    Conserved Domains (1) summary
    pfam00151
    Location:16 → 320
    Lipase; Lipase

  2. NM_001206961.2 → NP_001193890.1  phospholipase A1 member A isoform 3

    See identical proteins and their annotated locations for NP_001193890.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. The resulting isoform (3) uses a downstream AUG start site and is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK301880, BC035347
    Consensus CDS
    CCDS56269.1
    UniProtKB/Swiss-Prot
    Q53H76
    Related
    ENSP00000420625.1, ENST00000488919.5
    Conserved Domains (1) summary
    cl21494
    Location:2 → 159
    Abhydrolase; alpha/beta hydrolases

  3. NM_001293225.2 → NP_001280154.1  phospholipase A1 member A isoform 4

    See identical proteins and their annotated locations for NP_001280154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC035347, BX647516
    Consensus CDS
    CCDS77795.1
    UniProtKB/TrEMBL
    G5E9W0
    Related
    ENSP00000418793.1, ENST00000494440.5
    Conserved Domains (2) summary
    cd00707
    Location:33 → 316
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:10 → 320
    Lipase; Lipase

  4. NM_015900.4 → NP_056984.1  phospholipase A1 member A isoform 1 precursor

    See identical proteins and their annotated locations for NP_056984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK313519, BC035347
    Consensus CDS
    CCDS2991.1
    UniProtKB/Swiss-Prot
    B2R8V2, B4DXA2, O95991, Q53H76, Q86WX6, Q9UPD2
    Related
    ENSP00000273371.4, ENST00000273371.9
    Conserved Domains (2) summary
    cd00707
    Location:49 → 332
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:16 → 336
    Lipase; Lipase

RNA

  1. NR_120610.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF035269, BC035347, DB189568

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    119597885..119629811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006572.2 → XP_016862061.1  phospholipase A1 member A isoform X1

    UniProtKB/Swiss-Prot
    Q53H76
    Conserved Domains (1) summary
    cl21494
    Location:2 → 159
    Abhydrolase; alpha/beta hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    122317610..122349514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346775.1 → XP_054202750.1  phospholipase A1 member A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q53H76.2 GenPept UniProtKB/Swiss-Prot:Q53H76

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