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RNF138 ring finger protein 138 [ Homo sapiens (human) ]

Gene ID: 51444, updated on 16-Apr-2024

Summary

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Official Symbol
RNF138provided by HGNC
Official Full Name
ring finger protein 138provided by HGNC
Primary source
HGNC:HGNC:17765
See related
Ensembl:ENSG00000134758 MIM:616319; AllianceGenome:HGNC:17765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NARF; HSD-4; STRIN; hNARF
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 31.9), bone marrow (RPKM 30.7) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
18q12.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (32091874..32131561)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (32282268..32321925)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (29671837..29711524)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 125 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 44 Neighboring gene Sharpr-MPRA regulatory region 2735 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:29637632-29638167 Neighboring gene ribosomal protein S15a pseudogene 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13210 Neighboring gene uncharacterized LOC124904278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9388 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13212 Neighboring gene MPRA-validated peak3106 silencer Neighboring gene MPRA-validated peak3107 silencer Neighboring gene MPRA-validated peak3110 silencer Neighboring gene MPRA-validated peak3111 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9389 Neighboring gene RNA, 5S ribosomal pseudogene 453 Neighboring gene meprin A subunit beta Neighboring gene clustered mitochondria homolog pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway. Wu H, et al. Oncol Rep, 2018 Dec. PMID 30272353, Free PMC Article
  2. RNF138 confers cisplatin resistance in gastric cancer cells via activating Chk1 signaling pathway. Lu Y, et al. Cancer Biol Ther, 2018. PMID 30260263, Free PMC Article
  3. A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251. Zhou YX, et al. Anal Cell Pathol (Amst), 2012. PMID 22155992, Free PMC Article
  4. The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells. Averbeck NB, et al. Cells, 2022 Aug 17. PMID 36010636, Free PMC Article
  5. Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway. Liu H, et al. Int J Mol Med, 2021 Jun. PMID 33907817, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation.
    Title: The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation.
  2. RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
    Title: RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.
  3. The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
    Title: The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
  4. RING finger 138 deregulation distorts NF-small ka, CyrillicB signaling and facilities colitis switch to aggressive malignancy.
    Title: RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.
  5. African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1.
    Title: African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1.
  6. Silencing microRNA29b3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway.
    Title: Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway.
  7. data suggest that RNF138 modulates the cisplatin resistance in the GC cells, thus serving as a potential drug target to challenge chemotherapy failure. In addition, RNF138 can also be used as a marker to monitor the development of cisplatin resistance in GC treatment.
    Title: RNF138 confers cisplatin resistance in gastric cancer cells via activating Chk1 signaling pathway.
  8. The role of RNF138 in glioblastoma and identify rpS3 as a crucial substrate of ubiquitination by RNF138, which underlies the radioresistance of glioblastoma.
    Title: RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis.
  9. Study suggested that RNF138 was important for the proliferation, migration and invasion of glioma cells. Its downregulation inhibited the process of EMT by suppressing Erk signaling pathway in glioma.
    Title: Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway.
  10. This study identify RNF138 as the E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human CaV2.1 protein.
    Title: Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Ca(v)2.1 (P/Q-Type) Calcium Channels.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8758

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break processing involved in repair via single-strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA double-strand break processing involved in repair via single-strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF138
Names
NLK-associated RING finger protein
Nemo-like kinase-associated RING finger protein
RING-type E3 ubiquitin transferase RNF138
nemo-like kinase associated ring finger protein
ring finger protein 138, E3 ubiquitin protein ligase
testicular tissue protein Li 165
NP_001178253.2
NP_057355.2
NP_937761.1
XP_005258342.1
XP_005258343.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029944.1 RefSeqGene

    Range
    5020..44707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001191324.2 → NP_001178253.2  E3 ubiquitin-protein ligase RNF138 isoform 1

    See identical proteins and their annotated locations for NP_001178253.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK023579, BC018107, DA752192
    Consensus CDS
    CCDS11903.1
    UniProtKB/Swiss-Prot
    B2RE17, Q8WVD3, Q9H8K2, Q9UF87, Q9UKI6
    UniProtKB/TrEMBL
    A0A140VJT9
    Conserved Domains (3) summary
    cd16544
    Location:14 → 59
    RING-HC_RNF138; RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins
    pfam05605
    Location:156 → 215
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:80 → 112
    zf_C2HC_14; C2HC Zing finger domain

  2. NM_016271.5 → NP_057355.2  E3 ubiquitin-protein ligase RNF138 isoform 1

    See identical proteins and their annotated locations for NP_057355.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC011825, BC018107, DB452430
    Consensus CDS
    CCDS11903.1
    UniProtKB/Swiss-Prot
    B2RE17, Q8WVD3, Q9H8K2, Q9UF87, Q9UKI6
    UniProtKB/TrEMBL
    A0A140VJT9
    Related
    ENSP00000261593.3, ENST00000261593.8
    Conserved Domains (3) summary
    cd16544
    Location:14 → 59
    RING-HC_RNF138; RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins
    pfam05605
    Location:156 → 215
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:80 → 112
    zf_C2HC_14; C2HC Zing finger domain

  3. NM_198128.3 → NP_937761.1  E3 ubiquitin-protein ligase RNF138 isoform 2

    See identical proteins and their annotated locations for NP_937761.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AK023579, BC018107, DB091985
    Consensus CDS
    CCDS11904.1
    UniProtKB/Swiss-Prot
    Q8WVD3
    Related
    ENSP00000257190.5, ENST00000257190.9
    Conserved Domains (2) summary
    pfam05605
    Location:62 → 121
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cl17238
    Location:14 → 37
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    32091874..32131561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258286.3 → XP_005258343.1  E3 ubiquitin-protein ligase RNF138 isoform X1

    See identical proteins and their annotated locations for XP_005258343.1

    UniProtKB/Swiss-Prot
    Q8WVD3
    Conserved Domains (2) summary
    pfam05605
    Location:62 → 121
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cl17238
    Location:14 → 37
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_005258285.2 → XP_005258342.1  E3 ubiquitin-protein ligase RNF138 isoform X2

    See identical proteins and their annotated locations for XP_005258342.1

    Conserved Domains (2) summary
    pfam05605
    Location:110 → 169
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:34 → 66
    zf_C2HC_14; C2HC Zing finger domain

RNA

  1. XR_935225.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    32282268..32321925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WVD3.1 GenPept UniProtKB/Swiss-Prot:Q8WVD3

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