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ARMCX3 armadillo repeat containing X-linked 3 [ Homo sapiens (human) ]

Gene ID: 51566, updated on 3-Apr-2024

Summary

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Official Symbol
ARMCX3provided by HGNC
Official Full Name
armadillo repeat containing X-linked 3provided by HGNC
Primary source
HGNC:HGNC:24065
See related
Ensembl:ENSG00000102401 MIM:300364; AllianceGenome:HGNC:24065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALEX3; GASP6; dJ545K15.2
Summary
This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 17.0), thyroid (RPKM 15.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xq22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101623151..101627843)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (100067782..100072474)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100878141..100882833)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing X-linked 7, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:100868599-100869161 Neighboring gene armadillo repeat containing X-linked 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29812 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:100878731-100879930 Neighboring gene RNA, U6 small nuclear 30, pseudogene Neighboring gene armadillo repeat containing X-linked 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3. Serrat R, et al. PLoS One, 2013. PMID 23844091, Free PMC Article
  2. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Kurochkin IV, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162520
  3. Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway. Du J, et al. Tumour Biol, 2017 Jul. PMID 28705116
  4. The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. Mou Z, et al. J Biol Chem, 2009 May 15. PMID 19304657, Free PMC Article
  5. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0443, MGC12199, DKFZp781N1954

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonal transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
armadillo repeat-containing X-linked protein 3
Names
ARM protein lost in epithelial cancers on chromosome X 3
arm protein lost in epithelial cancers, X chromosome, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013222.2 RefSeqGene

    Range
    5002..9694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016607.4 → NP_057691.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_057691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC234775, BC005194, BG035798, BM905704, BX647802
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q53HC6, Q7LCF5, Q9NPE4, Q9UH62
    UniProtKB/TrEMBL
    A8K5B0
    Related
    ENSP00000340672.4, ENST00000341189.8
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like

  2. NM_177947.3 → NP_808816.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_808816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC234775, BC005194, BG035798, BX647802
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q53HC6, Q7LCF5, Q9NPE4, Q9UH62
    UniProtKB/TrEMBL
    A8K5B0
    Related
    ENSP00000454483.1, ENST00000471229.7
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like

  3. NM_177948.3 → NP_808817.1  armadillo repeat-containing X-linked protein 3

    See identical proteins and their annotated locations for NP_808817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1, and represents the shortest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC234775, BC005194, BM905704, BX647802, CA397688
    Consensus CDS
    CCDS14489.1
    UniProtKB/Swiss-Prot
    Q53HC6, Q7LCF5, Q9NPE4, Q9UH62
    UniProtKB/TrEMBL
    A8K5B0
    Related
    ENSP00000439032.1, ENST00000537169.1
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    101623151..101627843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262141.4 → XP_005262198.1  armadillo repeat-containing X-linked protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005262198.1

    UniProtKB/Swiss-Prot
    Q53HC6, Q7LCF5, Q9NPE4, Q9UH62
    UniProtKB/TrEMBL
    A8K5B0
    Conserved Domains (2) summary
    sd00043
    Location:156 → 190
    ARM; armadillo repeat [structural motif]
    pfam04826
    Location:112 → 363
    Arm_2; Armadillo-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    100067782..100072474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327180.1 → XP_054183155.1  armadillo repeat-containing X-linked protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q53HC6, Q7LCF5, Q9NPE4, Q9UH62
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UH62.1 GenPept UniProtKB/Swiss-Prot:Q9UH62

Gene LinkOut

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