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CUTA cutA divalent cation tolerance homolog [ Homo sapiens (human) ]

Gene ID: 51596, updated on 2-Nov-2024

Summary

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Official Symbol
CUTAprovided by HGNC
Official Full Name
cutA divalent cation tolerance homologprovided by HGNC
Primary source
HGNC:HGNC:21101
See related
Ensembl:ENSG00000112514 MIM:616953; AllianceGenome:HGNC:21101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACHAP; C6orf82
Summary
Enables enzyme binding activity. Involved in protein localization. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 52.9), adrenal (RPKM 52.0) and 25 other tissues See more
Orthologs
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Genomic context

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See CUTA in Genome Data Viewer
Location:
6p21.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33416442..33418107, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33237804..33239469, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33384219..33385884, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene kinesin family member C1 Neighboring gene ribosomal protein L12 pseudogene 1 Neighboring gene PHD finger protein 1 Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33393157-33393699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33396849-33397470 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33405630-33405807 Neighboring gene SYNGAP1 antisense RNA 1 Neighboring gene microRNA 5004 Neighboring gene zinc finger and BTB domain containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of the human CUTA isoform2 present in the stably transfected HeLa cells. Yang J, et al. Mol Biol Rep, 2009 Jan. PMID 17924204
  2. Thermodynamic analysis of unusually thermostable CutA1 protein from human brain and its protease susceptibility. Bagautdinov B, et al. J Biochem, 2015 Mar. PMID 25344844
  3. Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. Hou P, et al. Neurobiol Aging, 2015 Mar. PMID 25557959
  4. Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. Navaratnam DS, et al. J Neurochem, 2000 May. PMID 10800960
  5. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. Perrier AL, et al. J Biol Chem, 2000 Nov 3. PMID 10954708

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
    Title: Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.
  2. Human CutA1 exhibits remarkably high thermodynamic stability at body temperature should be important for its protein catabolism in the human cells.
    Title: Thermodynamic analysis of unusually thermostable CutA1 protein from human brain and its protease susceptibility.
  3. It mediates APP processing and Abeta generation.
    Title: Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation.
  4. H component of CUTA as a novel BACE1-interacting protein that mediates the intracellular trafficking of BACE1 and the processing of APP to Abeta
    Title: CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-site APP cleaving protein 1 (BACE1).
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  6. expression profile of CUTA gene in tissues was examined & revealed CUTA gene was constitutively expressed in the 18 tissues tested; CUTA isoform2 was mainly located in mitochondria as a new potential mitochondrial protein
    Title: Characterization of the human CUTA isoform2 present in the stably transfected HeLa cells.
  7. Fluorescence in situ hybridization localizes the gene to chromosome 6p21.32-p21.2.
    Title: Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization.
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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to metal ion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
protein CutA
Names
acetylcholinesterase-associated protein
brain acetylcholinesterase putative membrane anchor
divalent cation tolerant protein CUTA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014433.3 → NP_001014433.2  protein CutA isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform has also been named isoform a.
    Source sequence(s)
    AL662799, BX334868
    Consensus CDS
    CCDS4779.1
    Related
    ENSP00000363624.6, ENST00000374500.10
    Conserved Domains (1) summary
    pfam03091
    Location:48 → 143
    CutA1; CutA1 divalent ion tolerance protein

  2. NM_001014837.2 → NP_001014837.1  protein CutA isoform 1

    See identical proteins and their annotated locations for NP_001014837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 has also been called isoform c. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF106943, AL533788, AL662799, BG472577, CN363642
    Consensus CDS
    CCDS4779.1
    UniProtKB/Swiss-Prot
    O60888
    Related
    ENSP00000363620.3, ENST00000374496.3
    Conserved Domains (1) summary
    pfam03091
    Location:48 → 143
    CutA1; CutA1 divalent ion tolerance protein

  3. NM_001014838.2 → NP_001014838.1  protein CutA isoform 1

    See identical proteins and their annotated locations for NP_001014838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 has also been called isoform c. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF106943, AL533788, AL662799, BU540844
    Consensus CDS
    CCDS4779.1
    UniProtKB/Swiss-Prot
    O60888
    Related
    ENSP00000475963.1, ENST00000607266.5
    Conserved Domains (1) summary
    pfam03091
    Location:48 → 143
    CutA1; CutA1 divalent ion tolerance protein

  4. NM_001014840.2 → NP_001014840.1  protein CutA isoform 3 precursor

    See identical proteins and their annotated locations for NP_001014840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 3). Isoform 3 has also been called isoform b.
    Source sequence(s)
    AF106943, AL662799, CB106834, CN363642
    Consensus CDS
    CCDS34433.1
    UniProtKB/Swiss-Prot
    A2AB26, A2BEL4, O60888, Q3B784, Q5JXM9, Q5SU05, Q9NYQ9
    Related
    ENSP00000417544.1, ENST00000488034.6
    Conserved Domains (1) summary
    pfam03091
    Location:71 → 166
    CutA1; CutA1 divalent ion tolerance protein

  5. NM_015921.3 → NP_057005.1  protein CutA isoform 1

    See identical proteins and their annotated locations for NP_057005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 has also been called isoform c. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF106943, AL533788, AL662799
    Consensus CDS
    CCDS4779.1
    UniProtKB/Swiss-Prot
    O60888
    Related
    ENSP00000403268.2, ENST00000440279.7
    Conserved Domains (1) summary
    pfam03091
    Location:48 → 143
    CutA1; CutA1 divalent ion tolerance protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    33416442..33418107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    4865167..4866832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    33237804..33239469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60888.2 GenPept UniProtKB/Swiss-Prot:O60888

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