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FKBP7 FKBP prolyl isomerase 7 [ Homo sapiens (human) ]

Gene ID: 51661, updated on 19-Sep-2024

Summary

Official Symbol
FKBP7provided by HGNC
Official Full Name
FKBP prolyl isomerase 7provided by HGNC
Primary source
HGNC:HGNC:3723
See related
Ensembl:ENSG00000079150 MIM:607062; AllianceGenome:HGNC:3723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP23; PPIase
Summary
The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 13.6), endometrium (RPKM 9.0) and 21 other tissues See more
Orthologs
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Genomic context

See FKBP7 in Genome Data Viewer
Location:
2q31.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (178463664..178478600, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (178946457..178961394, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (179328391..179343327, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cholesterol induced regulator of metabolism RNA Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:179315058-179315632 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene uncharacterized LOC124906102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12150 Neighboring gene uncharacterized LOC124907911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16805 Neighboring gene nuclear distribution C pseudogene 2 Neighboring gene pejvakin Neighboring gene pleckstrin homology domain containing A3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12151 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:179387607-179388119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16810 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179401104-179402303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16811 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:179407630-179408829 Neighboring gene TTN antisense RNA 1 Neighboring gene titin Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179440205-179441404 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:179443309-179444508 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:179456337-179457536 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179471933-179473132 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:179478848-179480047

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC9420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FK506 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP7
Names
23 kDa FK506-binding protein
23 kDa FKBP
FK506 binding protein 7
FK506-binding protein 23
FKBP-23
FKBP-7
PPIase FKBP7
rotamase
NP_001128684.1
NP_001397901.1
NP_851939.1
XP_011509650.1
XP_011509651.1
XP_054198524.1
XP_054198525.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135212.2NP_001128684.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform b precursor

    See identical proteins and their annotated locations for NP_001128684.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (b) is 1 amino acid shorter than isoform a.
    Source sequence(s)
    AA447628, AC009948, AY353086, BC009711, DA020387
    Consensus CDS
    CCDS46462.1
    UniProtKB/Swiss-Prot
    Q9Y680
    Related
    ENSP00000415486.2, ENST00000434643.6
    Conserved Domains (3) summary
    pfam00254
    Location:46140
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:151213
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:151212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001410972.1NP_001397901.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC009948, AK299215
    Consensus CDS
    CCDS92911.1
    UniProtKB/TrEMBL
    B4DRE2
    Related
    ENSP00000509396.1, ENST00000464248.1
  3. NM_181342.3NP_851939.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform a precursor

    See identical proteins and their annotated locations for NP_851939.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA447628, AC009948, BC009711, DA020387
    Consensus CDS
    CCDS2280.1
    UniProtKB/Swiss-Prot
    Q4ZG70, Q6V3B2, Q86U65, Q96DA4, Q9Y680, Q9Y6B0
    Related
    ENSP00000413152.2, ENST00000424785.7
    Conserved Domains (2) summary
    pfam00254
    Location:46141
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:152214
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    178463664..178478600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511349.4XP_011509651.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X2

    Conserved Domains (3) summary
    pfam13499
    Location:44106
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:44105
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl19519
    Location:1733
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  2. XM_011511348.4XP_011509650.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1

    Conserved Domains (3) summary
    pfam13499
    Location:45107
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:45106
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl19519
    Location:1734
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RNA

  1. XR_007076405.1 RNA Sequence

  2. XR_007076404.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    178946457..178961394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342550.1XP_054198525.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X2

  2. XM_054342549.1XP_054198524.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1

RNA

  1. XR_008486417.1 RNA Sequence

  2. XR_008486416.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016105.2: Suppressed sequence

    Description
    NM_016105.2: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a valid protein.