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Mcrs1 microspherule protein 1 [ Mus musculus (house mouse) ]

Gene ID: 51812, updated on 28-Oct-2024

Summary

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Official Symbol
Mcrs1provided by MGI
Official Full Name
microspherule protein 1provided by MGI
Primary source
MGI:MGI:1858420
See related
Ensembl:ENSMUSG00000037570 AllianceGenome:MGI:1858420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P78; MSP58; ICP22BP
Summary
Predicted to enable RNA binding activity and telomerase inhibitor activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in several cellular components, including dendrite; nuclear lumen; and perikaryon. Predicted to be part of Ino80 complex; MLL1 complex; and NSL complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 38.4), testis adult (RPKM 37.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mcrs1 in Genome Data Viewer
Location:
15 F1; 15 56.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99140698..99149838, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99242817..99251961, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183 Neighboring gene STARR-seq mESC enhancer starr_39699 Neighboring gene predicted gene, 46538 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99082061-99082244 Neighboring gene STARR-positive B cell enhancer ABC_E1486 Neighboring gene STARR-positive B cell enhancer ABC_E7417 Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis. Ju JQ, et al. EMBO Rep, 2023 May 4. PMID 36951681, Free PMC Article
  2. MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation. Fawal MA, et al. Dev Cell, 2015 Apr 6. PMID 25816988
  3. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. Garrido A, et al. J Hepatol, 2022 Apr. PMID 34958836, Free PMC Article
  4. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. Ren Y, et al. Eur J Biochem, 1998 May 1. PMID 9654073
  5. MCRS1 is essential for epiblast development during early mouse embryogenesis. Cui W, et al. Reproduction, 2020 Jan. PMID 31671403, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.
    Title: Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.
  2. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
    Title: Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.
  3. MCRS1 is essential for epiblast development during early mouse embryogenesis.
    Title: MCRS1 is essential for epiblast development during early mouse embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103140, MGC117915

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-quadruplex RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables G-quadruplex RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables poly(G) binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(G) binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(U) RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables telomerase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
microspherule protein 1
Names
58 kDa microspherule protein
nucleolar protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164156.2 → NP_001157628.1  microspherule protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001157628.1

    Status: VALIDATED

    Source sequence(s)
    AC161198
    Consensus CDS
    CCDS49728.1
    UniProtKB/TrEMBL
    Q3TJY1, Q3TYU7
    Related
    ENSMUSP00000131407.2, ENSMUST00000163506.3
    Conserved Domains (2) summary
    cd00060
    Location:332 → 432
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:121 → 318
    MCRS_N; N-terminal region of micro-spherule protein

  2. NM_001411911.1 → NP_001398840.1  microspherule protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161198
    UniProtKB/Swiss-Prot
    O35255, Q32P11, Q99L90

  3. NM_016766.4 → NP_058046.2  microspherule protein 1 isoform 1

    See identical proteins and their annotated locations for NP_058046.2

    Status: VALIDATED

    Source sequence(s)
    AC161198
    Consensus CDS
    CCDS37199.1
    UniProtKB/Swiss-Prot
    O35255, Q32P11, Q99L90
    UniProtKB/TrEMBL
    Q3TYU7
    Related
    ENSMUSP00000043901.10, ENSMUST00000041190.17
    Conserved Domains (2) summary
    cd00060
    Location:345 → 445
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:134 → 331
    MCRS_N; N-terminal region of micro-spherule protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99140698..99149838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L90.1 GenPept UniProtKB/Swiss-Prot:Q99L90

Gene LinkOut

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