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Tmem141 transmembrane protein 141 [ Mus musculus (house mouse) ]

Gene ID: 51875, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem141provided by MGI
Official Full Name
transmembrane protein 141provided by MGI
Primary source
MGI:MGI:1098773
See related
Ensembl:ENSMUSG00000026939 AllianceGenome:MGI:1098773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Ertd217e; 1110065P14Rik
Summary
Predicted to be located in membrane. Is expressed in retina. Orthologous to human TMEM141 (transmembrane protein 141). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 17.0), bladder adult (RPKM 12.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem141 in Genome Data Viewer
Location:
2 A3; 2 17.57 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25510078..25512059, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25620066..25622047, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAB, member RAS oncogene family-like 6 Neighboring gene coiled-coil domain containing 183 Neighboring gene ficolin A, opposite strand Neighboring gene ficolin A Neighboring gene predicted gene, 35630 Neighboring gene lipocalin 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. Bulfone A, et al. Hum Mol Genet, 2000 May 22. PMID 10814725
  2. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 141

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040130.3 → NP_001035219.2  transmembrane protein 141 isoform 1

    See identical proteins and their annotated locations for NP_001035219.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI852650, AK004380, BY648636, BY704611, CD774285
    Consensus CDS
    CCDS50534.1
    UniProtKB/Swiss-Prot
    A2AJB2
    UniProtKB/TrEMBL
    F8WGV9
    Related
    ENSMUSP00000121862.2, ENSMUST00000142087.2
    Conserved Domains (1) summary
    pfam15110
    Location:6 → 96
    TMEM141; TMEM141 protein family

  2. NM_001109993.1 → NP_001103463.1  transmembrane protein 141 isoform 2

    See identical proteins and their annotated locations for NP_001103463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AI852650, BC048537, BY281807, CD774285
    UniProtKB/TrEMBL
    Q80ZR4
    Related
    ENSMUST00000150165.8
    Conserved Domains (1) summary
    pfam15110
    Location:1 → 65
    TMEM141; TMEM141 protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25510078..25512059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498180.4 → XP_006498243.1  transmembrane protein 141 isoform X1

    See identical proteins and their annotated locations for XP_006498243.1

    UniProtKB/TrEMBL
    Q80ZR4
    Conserved Domains (1) summary
    pfam15110
    Location:1 → 65
    TMEM141; TMEM141 protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJB2.1 GenPept UniProtKB/Swiss-Prot:A2AJB2

Gene LinkOut

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