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PFDN4 prefoldin subunit 4 [ Homo sapiens (human) ]

Gene ID: 5203, updated on 5-Mar-2024

Summary

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Official Symbol
PFDN4provided by HGNC
Official Full Name
prefoldin subunit 4provided by HGNC
Primary source
HGNC:HGNC:8868
See related
Ensembl:ENSG00000101132 MIM:604898; AllianceGenome:HGNC:8868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1; PFD4
Summary
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.8), endometrium (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

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See PFDN4 in Genome Data Viewer
Location:
20q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (54208087..54219961)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (55982176..55994287)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (52824626..52836500)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18140 Neighboring gene uncharacterized LOC124904937 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:52824023-52824840 and GRCh37_chr20:52824841-52825657 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13055 Neighboring gene uncharacterized LOC107985385 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:52901007-52902206 Neighboring gene NANOG hESC enhancer GRCh37_chr20:52976162-52976663 Neighboring gene docking protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Abnormal expression of PFDN4 in colorectal cancer: a novel marker for prognosis. Miyoshi N, et al. Ann Surg Oncol, 2010 Nov. PMID 20552408
  2. Comprehensive genome sequence analysis of a breast cancer amplicon. Collins C, et al. Genome Res, 2001 Jun. PMID 11381030, Free PMC Article
  3. Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer. Sadeghi H, et al. J Cell Physiol, 2021 Mar. PMID 32743796
  4. Molecular chaperones in the cytosol: from nascent chain to folded protein. Hartl FU, et al. Science, 2002 Mar 8. PMID 11884745
  5. Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines. Iijima M, et al. Acta Med Okayama, 1996 Apr. PMID 8744932

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer.
    Title: Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer.
  2. PFDN4 inhibition resulted in an increase in cell growth and invasiveness in colorectal cancer cell lines.
    Title: Abnormal expression of PFDN4 in colorectal cancer: a novel marker for prognosis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding TAS
Traceable Author Statement
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of amyloid fibril formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of prefoldin complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
prefoldin subunit 4
Names
prefoldin 4
protein C-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002623.4 → NP_002614.2  prefoldin subunit 4

    See identical proteins and their annotated locations for NP_002614.2

    Status: REVIEWED

    Source sequence(s)
    AL133335, BC010953, U41816
    Consensus CDS
    CCDS13445.1
    UniProtKB/Swiss-Prot
    Q5TD11, Q92779, Q9NQP4
    UniProtKB/TrEMBL
    B2R548
    Related
    ENSP00000360473.2, ENST00000371419.7
    Conserved Domains (1) summary
    pfam01920
    Location:23 → 125
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    54208087..54219961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440198.1 → XP_047296154.1  prefoldin subunit 4 isoform X1

  2. XM_047440199.1 → XP_047296155.1  prefoldin subunit 4 isoform X3

  3. XM_017027879.2 → XP_016883368.1  prefoldin subunit 4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    55982176..55994287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323509.1 → XP_054179484.1  prefoldin subunit 4 isoform X3

  2. XM_054323507.1 → XP_054179482.1  prefoldin subunit 4 isoform X1

  3. XM_054323508.1 → XP_054179483.1  prefoldin subunit 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQP4.1 GenPept UniProtKB/Swiss-Prot:Q9NQP4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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