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Rcn3 reticulocalbin 3, EF-hand calcium binding domain [ Mus musculus (house mouse) ]

Gene ID: 52377, updated on 2-Nov-2024

Summary

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Official Symbol
Rcn3provided by MGI
Official Full Name
reticulocalbin 3, EF-hand calcium binding domainprovided by MGI
Primary source
MGI:MGI:1277122
See related
Ensembl:ENSMUSG00000019539 AllianceGenome:MGI:1277122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RLP49; D7Ertd671e; 6030455P07Rik; D530026G20Rik
Summary
Predicted to enable calcium ion binding activity. Involved in several processes, including ERAD pathway; phospholipid homeostasis; and surfactant homeostasis. Located in endoplasmic reticulum. Is expressed in several structures, including aorta; brain; genitourinary system; gut gland; and trachea. Orthologous to human RCN3 (reticulocalbin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 194.2), ovary adult (RPKM 178.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Rcn3 in Genome Data Viewer
Location:
7 B3; 7 29.11 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44732338..44741746, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45082914..45092322, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene nitric oxide synthase interacting protein Neighboring gene Fc fragment of IgG receptor and transporter Neighboring gene STARR-seq mESC enhancer starr_18830 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52376860-52377101 Neighboring gene predicted gene 45552 Neighboring gene microRNA 150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation. Park NR, et al. Sci Rep, 2021 May 25. PMID 34035379, Free PMC Article
  2. Reticulocalbin 3 deficiency in alveolar epithelium attenuated LPS-induced ALI via NF-κB signaling. Shi X, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Apr 1. PMID 33625944
  3. Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis. Jin J, et al. Am J Respir Cell Mol Biol, 2018 Sep. PMID 29676583
  4. Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals. Korneenko TV, et al. Sci Rep, 2016 Mar 4. PMID 26939788, Free PMC Article
  5. Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Jin J, et al. Am J Respir Cell Mol Biol, 2016 Mar. PMID 26252542

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102610

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lung epithelium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
reticulocalbin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355045.1 → NP_001341974.1  reticulocalbin-3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126256
    Consensus CDS
    CCDS21229.1
    UniProtKB/Swiss-Prot
    Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4
    UniProtKB/TrEMBL
    A0A1B0GR86
    Related
    ENSMUSP00000148227.2, ENSMUST00000211352.2
    Conserved Domains (1) summary
    cd16230
    Location:44 → 311
    EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)

  2. NM_026555.2 → NP_080831.2  reticulocalbin-3 precursor

    See identical proteins and their annotated locations for NP_080831.2

    Status: VALIDATED

    Source sequence(s)
    AK077943, AV129283, BY248337
    Consensus CDS
    CCDS21229.1
    UniProtKB/Swiss-Prot
    Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4
    UniProtKB/TrEMBL
    A0A1B0GR86
    Related
    ENSMUSP00000019683.4, ENSMUST00000019683.11
    Conserved Domains (1) summary
    cd16230
    Location:44 → 311
    EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44732338..44741746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540987.4 → XP_006541050.1  reticulocalbin-3 isoform X1

    See identical proteins and their annotated locations for XP_006541050.1

    UniProtKB/Swiss-Prot
    Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4
    UniProtKB/TrEMBL
    A0A1B0GR86
    Related
    ENSMUSP00000147341.2, ENSMUST00000210469.2
    Conserved Domains (1) summary
    cd16230
    Location:44 → 311
    EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH97.1 GenPept UniProtKB/Swiss-Prot:Q8BH97

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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