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Septin11 septin 11 [ Mus musculus (house mouse) ]

Gene ID: 52398, updated on 28-Oct-2024

Summary

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Official Symbol
Septin11provided by MGI
Official Full Name
septin 11provided by MGI
Primary source
MGI:MGI:1277214
See related
Ensembl:ENSMUSG00000058013 AllianceGenome:MGI:1277214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sept11; D5Ertd606e; 6230410I01Rik
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of synapse organization. Part of septin complex. Is expressed in brain; inner ear; and testis. Orthologous to human SEPTIN11 (septin 11). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 26.3), limb E14.5 (RPKM 19.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Septin11 in Genome Data Viewer
Location:
5 E2; 5 47.29 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (93227445..93329237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (93090995..93182368)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sosondowah ankyrin repeat domain family member B Neighboring gene predicted gene, 22915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93522357-93522466 Neighboring gene STARR-seq mESC enhancer starr_13664 Neighboring gene VISTA enhancer mm39 Neighboring gene cyclin I Neighboring gene RIKEN cDNA 2010109A12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93635715-93635902 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lethal phenotype of mice carrying a Sept11 null mutation. Röseler S, et al. Biol Chem, 2011 Aug. PMID 21824005
  2. Physiological significance of WDR45, a responsible gene for β-propeller protein associated neurodegeneration (BPAN), in brain development. Noda M, et al. Sci Rep, 2021 Nov 19. PMID 34799629, Free PMC Article
  3. MUNC18-1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development. Hamada N, et al. Acta Neuropathol Commun, 2017 Nov 30. PMID 29191246, Free PMC Article
  4. Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. Shinoda T, et al. Mol Biol Cell, 2010 Apr 15. PMID 20181826, Free PMC Article
  5. Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Ageta-Ishihara N, et al. Nat Commun, 2013. PMID 24113571, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization of symmetric synapse ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
septin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009818.2 → NP_001009818.1  septin-11 isoform 3

    See identical proteins and their annotated locations for NP_001009818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC134827, BC064466, CO042161
    Consensus CDS
    CCDS51549.1
    UniProtKB/TrEMBL
    A0A0J9YTY0
    Related
    ENSMUSP00000074293.8, ENSMUST00000074733.11
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  2. NM_001310669.1 → NP_001297598.1  septin-11 isoform 1

    See identical proteins and their annotated locations for NP_001297598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction in the 3' end compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is 1 aa shorter compared to isoform 4.
    Source sequence(s)
    AC134827, AK028475
    Consensus CDS
    CCDS80331.1
    UniProtKB/Swiss-Prot
    Q3TBA0, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0, Q8C1B7
    UniProtKB/TrEMBL
    A0A0J9YTY0
    Related
    ENSMUSP00000143928.2, ENSMUST00000201421.4
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  3. NM_001310671.1 → NP_001297600.1  septin-11 isoform 2

    See identical proteins and their annotated locations for NP_001297600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site in the 3' coding region compared to variant 4. The resulting isoform (2) is shorter at the C-terminus compared to isoform 4.
    Source sequence(s)
    AC134827
    Consensus CDS
    CCDS80332.1
    UniProtKB/TrEMBL
    A0A0J9YTY0
    Related
    ENSMUSP00000144136.2, ENSMUST00000202308.4
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  4. NM_001347377.1 → NP_001334306.1  septin-11 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC134827
    Consensus CDS
    CCDS84906.1
    UniProtKB/TrEMBL
    A0A0J9YTY0, A0A0J9YUL3
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    93227445..93329237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165288.1 → XP_036021181.1  septin-11 isoform X1

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  2. XM_036165289.1 → XP_036021182.1  septin-11 isoform X1

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  3. XM_006535098.5 → XP_006535161.1  septin-11 isoform X1

    See identical proteins and their annotated locations for XP_006535161.1

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  4. XM_006535099.5 → XP_006535162.1  septin-11 isoform X1

    See identical proteins and their annotated locations for XP_006535162.1

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  5. XM_006535100.5 → XP_006535163.1  septin-11 isoform X2

    See identical proteins and their annotated locations for XP_006535163.1

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  6. XM_006535101.5 → XP_006535164.1  septin-11 isoform X2

    See identical proteins and their annotated locations for XP_006535164.1

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  7. XM_006535103.5 → XP_006535166.1  septin-11 isoform X5

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  8. XM_011249531.4 → XP_011247833.1  septin-11 isoform X2

    See identical proteins and their annotated locations for XP_011247833.1

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  9. XM_017320978.3 → XP_017176467.1  septin-11 isoform X4

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  10. XM_011249532.4 → XP_011247834.1  septin-11 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:47 → 315
    CDC_Septin; CDC/Septin GTPase family

  11. XM_017320982.1 → XP_017176471.1  septin-11 isoform X10

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:1 → 249
    CDC_Septin; CDC/Septin GTPase family

  12. XM_017320980.3 → XP_017176469.1  septin-11 isoform X6

    UniProtKB/TrEMBL
    A0A0J9YTY0, A0A0J9YUL3
    Related
    ENSMUSP00000144235.2, ENSMUST00000202217.3
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  13. XM_030254690.2 → XP_030110550.1  septin-11 isoform X7

    UniProtKB/Swiss-Prot
    Q3TBA0, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0, Q8C1B7
    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  14. XM_017320981.3 → XP_017176470.1  septin-11 isoform X9

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Related
    ENSMUSP00000143901.2, ENSMUST00000201700.4
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  15. XM_006535104.5 → XP_006535167.1  septin-11 isoform X6

    See identical proteins and their annotated locations for XP_006535167.1

    UniProtKB/TrEMBL
    A0A0J9YTY0, A0A0J9YUL3
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  16. XM_036165291.1 → XP_036021184.1  septin-11 isoform X7

    UniProtKB/Swiss-Prot
    Q3TBA0, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0, Q8C1B7
    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  17. XM_006535108.4 → XP_006535171.1  septin-11 isoform X10

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:1 → 249
    CDC_Septin; CDC/Septin GTPase family

  18. XM_006535106.5 → XP_006535169.1  septin-11 isoform X8

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:36 → 304
    CDC_Septin; CDC/Septin GTPase family

  19. XM_030254691.1 → XP_030110551.1  septin-11 isoform X11

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:1 → 249
    CDC_Septin; CDC/Septin GTPase family

  20. XM_036165292.1 → XP_036021185.1  septin-11 isoform X11

    UniProtKB/TrEMBL
    A0A0J9YTY0
    Conserved Domains (1) summary
    cd01850
    Location:1 → 249
    CDC_Septin; CDC/Septin GTPase family

RNA

  1. XR_389284.5 RNA Sequence

  2. XR_001784719.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1B7.4 GenPept UniProtKB/Swiss-Prot:Q8C1B7

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