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PGR progesterone receptor [ Homo sapiens (human) ]

Gene ID: 5241, updated on 2-Nov-2024

Summary

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Official Symbol
PGRprovided by HGNC
Official Full Name
progesterone receptorprovided by HGNC
Primary source
HGNC:HGNC:8910
See related
Ensembl:ENSG00000082175 MIM:607311; AllianceGenome:HGNC:8910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR; NR3C3
Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Expression
Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5) See more
Orthologs
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Genomic context

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See PGR in Genome Data Viewer
Location:
11q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (101029624..101129813, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (101039187..101139328, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (100900355..101000544, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 42 Neighboring gene uncharacterized LOC105369457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5431 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18463 Neighboring gene Sharpr-MPRA regulatory region 5256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5432 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18498 Neighboring gene small nucleolar RNA, C/D box 13I Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:100848900-100849468 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:100849469-100850035 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:100953401-100953965 Neighboring gene MPRA-validated peak1438 silencer Neighboring gene PGR antisense RNA 1 Neighboring gene MTMR12 pseudogene 1 Neighboring gene uncharacterized LOC105369458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Intramolecular interactions between the AF3 domain and the C-terminus of the human progesterone receptor are mediated through two LXXLL motifs. Dong X, et al. J Mol Endocrinol, 2004 Jun. PMID 15171716
  2. Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women. Ho HP, et al. Psychoneuroendocrinology, 2004 Oct. PMID 15219637
  3. Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach. Lee E, et al. Carcinogenesis, 2010 Aug. PMID 20547493, Free PMC Article
  4. Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord. Gargiulo-Monachelli GM, et al. Eur J Neurol, 2014 Feb. PMID 24894997
  5. Association of the progesterone receptor gene polymorphism (PROGINS) with endometriosis: a meta-analysis. Pabalan N, et al. Arch Gynecol Obstet, 2014 Nov. PMID 24943061

See all (794) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Progesterone receptor distribution in the human hypothalamus and its association with suicide.
    Title: Progesterone receptor distribution in the human hypothalamus and its association with suicide.
  2. Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization.
    Title: Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization.
  3. USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.
    Title: USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.
  4. The role of progesterone receptor isoforms in the myometrium.
    Title: The role of progesterone receptor isoforms in the myometrium.
  5. Progesterone receptor expression and prediction of benefits of adjuvant radiotherapy in de novo atypical meningiomas after gross-total resection.
    Title: Progesterone receptor expression and prediction of benefits of adjuvant radiotherapy in de novo atypical meningiomas after gross-total resection.
  6. Association of Val660Leu, progesterone receptor polymorphic variant, with susceptibility to RRMS disease.
    Title: Association of Val660Leu, progesterone receptor polymorphic variant, with susceptibility to RRMS disease.
  7. Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients.
    Title: Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients.
  8. PRB inhibited cell proliferation through let-7b-E2F1 in breast cancer.
    Title: PRB inhibited cell proliferation through let-7b-E2F1 in breast cancer.
  9. A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer.
    Title: A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer.
  10. Interferon-gamma is quintessential for NOS2 and COX2 expression in ER[-] breast tumors that lead to poor outcome.
    Title: Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome.
Submit: New GeneRIF Correction See all GeneRIFs (645)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Progesterone resistance
MedGen: C1849699 OMIM: 264080 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables G protein-coupled receptor activity IC
Inferred by Curator
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in glandular epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
  
involved_in paracrine signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in progesterone receptor signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in progesterone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in tertiary branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
progesterone receptor
Names
nuclear receptor subfamily 3 group C member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016475.1 RefSeqGene

    Range
    5001..105190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000926.4 → NP_000917.3  progesterone receptor isoform B

    See identical proteins and their annotated locations for NP_000917.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (B).
    Source sequence(s)
    AP001533, M15716
    Consensus CDS
    CCDS8310.1
    UniProtKB/Swiss-Prot
    A7LQ08, A7X8B0, B4E3T0, P06401, Q8TDS3, Q9UPF7
    UniProtKB/TrEMBL
    Q8NG42
    Related
    ENSP00000325120.5, ENST00000325455.10
    Conserved Domains (3) summary
    cd07074
    Location:686 → 933
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:563 → 640
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1 → 564
    Prog_receptor; Progesterone receptor

  2. NM_001202474.3 → NP_001189403.1  progesterone receptor isoform A

    Status: REVIEWED

    Source sequence(s)
    AP001533, M15716
    UniProtKB/Swiss-Prot
    P06401
    Conserved Domains (3) summary
    cd07074
    Location:522 → 769
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cd07172
    Location:399 → 476
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1 → 400
    Prog_receptor; Progesterone receptor

  3. NM_001271161.2 → NP_001258090.1  progesterone receptor isoform C

    Status: REVIEWED

    Source sequence(s)
    AB084248, AP001533
    UniProtKB/Swiss-Prot
    P06401
    Related
    ENSP00000263463.5, ENST00000263463.9
    Conserved Domains (3) summary
    cd07172
    Location:399 → 475
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1 → 400
    Prog_receptor; Progesterone receptor
    cl11397
    Location:470 → 667
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  4. NM_001271162.2 → NP_001258091.1  progesterone receptor isoform D

    See identical proteins and their annotated locations for NP_001258091.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents an alternate first exon, compared to variant 1, resulting in a protein isoform (D) with a shorter N-terminus.
    Source sequence(s)
    AK304853, AP001533
    Consensus CDS
    CCDS59229.1
    UniProtKB/Swiss-Prot
    P06401
    Related
    ENSP00000436561.1, ENST00000534013.5
    Conserved Domains (2) summary
    cd07074
    Location:92 → 339
    NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
    cl02596
    Location:1 → 46
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RNA

  1. NR_073141.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
    Source sequence(s)
    AB085845, AP001533

  2. NR_073142.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
    Source sequence(s)
    AB085843, AP001533

  3. NR_073143.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) omits two coding exons, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
    Source sequence(s)
    AB085683, AP001533

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    101029624..101129813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718858.4 → XP_006718921.1  progesterone receptor isoform X1

    UniProtKB/TrEMBL
    Q8NG42
    Related
    ENSP00000432352.1, ENST00000534780.5
    Conserved Domains (3) summary
    cd07172
    Location:563 → 640
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02161
    Location:1 → 564
    Prog_receptor; Progesterone receptor
    cl11397
    Location:686 → 786
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  2. XM_011542869.3 → XP_011541171.1  progesterone receptor isoform X2

    UniProtKB/TrEMBL
    Q8NG43
    Conserved Domains (2) summary
    pfam02161
    Location:1 → 564
    Prog_receptor; Progesterone receptor
    cl02596
    Location:563 → 596
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    101039187..101139328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369129.1 → XP_054225104.1  progesterone receptor isoform X1

  2. XM_054369130.1 → XP_054225105.1  progesterone receptor isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06401.4 GenPept UniProtKB/Swiss-Prot:P06401

Gene LinkOut

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