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Nhp2 NHP2 ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 52530, updated on 2-Nov-2024

Summary

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Official Symbol
Nhp2provided by MGI
Official Full Name
NHP2 ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:1098547
See related
Ensembl:ENSMUSG00000001056 AllianceGenome:MGI:1098547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nola2; D11Ertd175e; 2410130M07Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in snRNA pseudouridine synthesis; snoRNA guided rRNA pseudouridine synthesis; and telomere maintenance via telomerase. Predicted to be located in Cajal body. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Is expressed in axial musculature; orbito-sphenoid; and pancreas mesenchyme. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 67.7), liver E14 (RPKM 49.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nhp2 in Genome Data Viewer
Location:
11 B1.3; 11 31.14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51510600..51514545)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51619773..51623718)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51347850-51348150 Neighboring gene STARR-positive B cell enhancer ABC_E6980 Neighboring gene STARR-seq mESC enhancer starr_29416 Neighboring gene STARR-positive B cell enhancer ABC_E3947 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene STARR-positive B cell enhancer ABC_E255 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene STARR-positive B cell enhancer ABC_E8400 Neighboring gene STARR-seq mESC enhancer starr_29422 Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene predicted gene, 30058 Neighboring gene NEDD4 binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Egan ED, et al. Mol Cell Biol, 2010 Jun. PMID 20351177, Free PMC Article
  2. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
  3. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. Kappei D, et al. EMBO J, 2013 Jun 12. PMID 23685356, Free PMC Article
  4. Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Kaput J, et al. Physiol Genomics, 2004 Aug 11. PMID 15306695
  5. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U3 snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables box H/ACA snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables box H/ACA snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables box H/ACA snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomerase RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA pseudouridine synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in snRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snoRNA guided rRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in telomere maintenance via telomerase NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
part_of box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box H/ACA snoRNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of box H/ACA snoRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of box H/ACA telomerase RNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of box H/ACA telomerase RNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of telomerase holoenzyme complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
H/ACA ribonucleoprotein complex subunit 2
Names
H/ACA small nucleolar RNPs
NHP2 ribonucleoprotein homolog
nucleolar protein family A, member 2
snoRNP protein NHP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364736.1 → NP_001351665.1  H/ACA ribonucleoprotein complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK019134, AV472909, CR518445
    Conserved Domains (1) summary
    cl00600
    Location:46 → 77
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

  2. NM_026631.4 → NP_080907.1  H/ACA ribonucleoprotein complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_080907.1

    Status: VALIDATED

    Source sequence(s)
    AL645602
    Consensus CDS
    CCDS24655.1
    UniProtKB/Swiss-Prot
    Q9CRB2
    Related
    ENSMUSP00000120014.2, ENSMUST00000127405.2
    Conserved Domains (1) summary
    pfam01248
    Location:46 → 137
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RNA

  1. NR_157294.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK019134, BF467095, CR518445

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51510600..51514545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRB2.1 GenPept UniProtKB/Swiss-Prot:Q9CRB2

Gene LinkOut

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