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Arhgef25 Rho guanine nucleotide exchange factor 25 [ Mus musculus (house mouse) ]

Gene ID: 52666, updated on 28-Oct-2024

Summary

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Official Symbol
Arhgef25provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 25provided by MGI
Primary source
MGI:MGI:1277173
See related
Ensembl:ENSMUSG00000019467 AllianceGenome:MGI:1277173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GEFT; D10Ertd610e; 2410008H17Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Located in myofibril and plasma membrane. Is expressed in several structures, including brain; eye; gut; metanephros; and otocyst. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in limb E14.5 (RPKM 49.4), bladder adult (RPKM 39.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgef25 in Genome Data Viewer
Location:
10 D3; 10 74.5 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127018390..127025952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127182521..127190083, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51819 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126608171-126608358 Neighboring gene solute carrier family 26, member 10 Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene deltex 3, E3 ubiquitin ligase Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. Bryan BA, et al. Mol Cell Biol, 2005 Dec. PMID 16314529, Free PMC Article
  2. p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility. Momotani K, et al. Circ Res, 2011 Oct 14. PMID 21885830, Free PMC Article
  3. GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism. Mitchell DC, et al. Curr Mol Med, 2011 Aug. PMID 21663592
  4. Geft is dispensable for the development of the second heart field. Fan X, et al. BMB Rep, 2012 Mar. PMID 22449701
  5. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. Ongherth A, et al. J Mol Cell Cardiol, 2015 Nov. PMID 26392029

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF.
    Title: p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
  2. The Geft knockout mice develop normally and exhibit no discernable phenotype, suggesting Geft is dispensable for the development of the second heart field in mouse.
    Title: Geft is dispensable for the development of the second heart field.
  3. Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Galpha(q/11)--p63RhoGEF--RhoA axis.
    Title: Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.
  4. GEFT regulation of lens differentiation and eye development occurs through a Rac1-dependent mechanism.
    Title: GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism.
  5. Signaling through p63RhoGEF provides a novel mechanism for selective regulation of blood pressure.
    Title: p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.
  6. Bves directly interacts with GEFT and is a novel regulator of the Rac1 and Cdc42 signaling cascades.
    Title: Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity.
  7. This protein induces cell proliferation, transformation, and migration.
    Title: A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 25
Names
Rho guanine nucleotide exchange factor (GEF) 25
guanine nucleotide exchange factor GEFT
p63RhoGEF
rac/Cdc42/Rho exchange factor GEFT
rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166413.2 → NP_001159885.1  rho guanine nucleotide exchange factor 25 isoform 2

    See identical proteins and their annotated locations for NP_001159885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC144852
    Consensus CDS
    CCDS48715.1
    UniProtKB/Swiss-Prot
    Q3TYF3, Q8R1Q4, Q9CWR0
    UniProtKB/TrEMBL
    A0A0R4J211
    Related
    ENSMUSP00000126339.2, ENSMUST00000167353.3
    Conserved Domains (2) summary
    cd13241
    Location:369 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:194 → 365
    RhoGEF; RhoGEF domain

  2. NM_001358557.2 → NP_001345486.1  rho guanine nucleotide exchange factor 25 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144852
    Consensus CDS
    CCDS88098.1
    UniProtKB/Swiss-Prot
    Q3TYF3, Q8R1Q4, Q9CWR0
    UniProtKB/TrEMBL
    A0A1W2P6R9
    Related
    ENSMUSP00000151325.2, ENSMUST00000218654.2
    Conserved Domains (2) summary
    cd00160
    Location:163 → 334
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:339 → 481
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

  3. NM_001358558.2 → NP_001345487.1  rho guanine nucleotide exchange factor 25 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC144852
    UniProtKB/Swiss-Prot
    Q3TYF3, Q8R1Q4, Q9CWR0
    Conserved Domains (2) summary
    cd00160
    Location:120 → 291
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:296 → 438
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

  4. NM_001428940.1 → NP_001415869.1  rho guanine nucleotide exchange factor 25 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC144852

  5. NM_028027.4 → NP_082303.2  rho guanine nucleotide exchange factor 25 isoform 1

    See identical proteins and their annotated locations for NP_082303.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC144852
    Consensus CDS
    CCDS24231.1
    UniProtKB/Swiss-Prot
    Q3TYF3, Q8R1Q4, Q9CWR0
    UniProtKB/TrEMBL
    G5E825
    Related
    ENSMUSP00000019611.8, ENSMUST00000019611.15
    Conserved Domains (2) summary
    cd13241
    Location:378 → 520
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 374
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127018390..127025952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245177.1 → XP_030101037.1  rho guanine nucleotide exchange factor 25 isoform X3

    Related
    ENSMUST00000219649.2
    Conserved Domains (2) summary
    cd00160
    Location:1 → 87
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:92 → 234
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

  2. XM_006513879.5 → XP_006513942.1  rho guanine nucleotide exchange factor 25 isoform X1

    Conserved Domains (2) summary
    cd00160
    Location:139 → 310
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:315 → 457
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

  3. XM_006513881.3 → XP_006513944.1  rho guanine nucleotide exchange factor 25 isoform X2

    See identical proteins and their annotated locations for XP_006513944.1

    UniProtKB/Swiss-Prot
    Q3TYF3, Q8R1Q4, Q9CWR0
    Conserved Domains (2) summary
    cd00160
    Location:120 → 291
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13241
    Location:296 → 438
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

RNA

  1. XR_871718.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWR0.1 GenPept UniProtKB/Swiss-Prot:Q9CWR0

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