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Zwint ZW10 interactor [ Mus musculus (house mouse) ]

Gene ID: 52696, updated on 2-Nov-2024

Summary

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Official Symbol
Zwintprovided by MGI
Official Full Name
ZW10 interactorprovided by MGI
Primary source
MGI:MGI:1289227
See related
Ensembl:ENSMUSG00000019923 AllianceGenome:MGI:1289227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zwint-1; D10Ertd749e; 2010007E07Rik; 2600001N01Rik
Summary
Involved in homologous chromosome orientation in meiotic metaphase I and regulation of meiosis I spindle assembly checkpoint. Located in kinetochore. Is expressed in several structures, including early conceptus; heart valve; nervous system; oocyte; and retina. Orthologous to human ZWINT (ZW10 interacting kinetochore protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 121.8), cerebellum adult (RPKM 118.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Zwint in Genome Data Viewer
Location:
10 B5.3; 10 37.15 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (72490678..72510796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (72654846..72674964)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24984 Neighboring gene STARR-seq mESC enhancer starr_27125 Neighboring gene STARR-positive B cell enhancer ABC_E1803 Neighboring gene predicted gene, 34659 Neighboring gene STARR-seq mESC enhancer starr_27126 Neighboring gene RIKEN cDNA A330049N07 gene Neighboring gene predicted gene, 34776

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis. Woo Seo D, et al. Sci Rep, 2015 Oct 21. PMID 26486467, Free PMC Article
  2. A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. van Vlijmen T, et al. FEBS Lett, 2008 Aug 20. PMID 18625232
  3. A two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30. Gentil BJ, et al. J Neurochem, 2014 Dec. PMID 25113441
  4. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
  5. PEG3 control on the mammalian MSL complex. Ye A, et al. PLoS One, 2017. PMID 28609438, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of localization in cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in homologous chromosome orientation in meiotic metaphase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of meiosis I spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Knl1/Spc105 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Knl1/Spc105 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ZW10 interactor
Names
ZW10-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293683.1 → NP_001280612.1  ZW10 interactor

    See identical proteins and their annotated locations for NP_001280612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK075977, BC034870, BY240779
    Consensus CDS
    CCDS23920.1
    UniProtKB/Swiss-Prot
    Q3UYT8, Q91VI4, Q9CQU5, Q9D0W9
    Related
    ENSMUSP00000020081.5, ENSMUST00000020081.11
    Conserved Domains (2) summary
    pfam15556
    Location:35 → 236
    Zwint; ZW10 interactor
    cl19764
    Location:126 → 215
    COG6; Conserved oligomeric complex COG6

  2. NM_001293684.1 → NP_001280613.1  ZW10 interactor

    See identical proteins and their annotated locations for NP_001280613.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC153870, AK008144, AK134380, BY240779
    Consensus CDS
    CCDS23920.1
    UniProtKB/Swiss-Prot
    Q3UYT8, Q91VI4, Q9CQU5, Q9D0W9
    Related
    ENSMUSP00000124429.2, ENSMUST00000160337.2
    Conserved Domains (2) summary
    pfam15556
    Location:35 → 236
    Zwint; ZW10 interactor
    cl19764
    Location:126 → 215
    COG6; Conserved oligomeric complex COG6

  3. NM_025635.4 → NP_079911.1  ZW10 interactor

    See identical proteins and their annotated locations for NP_079911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC153870, AK134380, BY240779
    Consensus CDS
    CCDS23920.1
    UniProtKB/Swiss-Prot
    Q3UYT8, Q91VI4, Q9CQU5, Q9D0W9
    Related
    ENSMUSP00000101071.2, ENSMUST00000105431.8
    Conserved Domains (2) summary
    pfam15556
    Location:35 → 236
    Zwint; ZW10 interactor
    cl19764
    Location:126 → 215
    COG6; Conserved oligomeric complex COG6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    72490678..72510796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQU5.1 GenPept UniProtKB/Swiss-Prot:Q9CQU5

Gene LinkOut

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