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Zfp410 zinc finger protein 410 [ Mus musculus (house mouse) ]

Gene ID: 52708, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp410provided by MGI
Official Full Name
zinc finger protein 410provided by MGI
Primary source
MGI:MGI:1289280
See related
Ensembl:ENSMUSG00000042472 AllianceGenome:MGI:1289280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apa1; Znf410; D12Ertd748e
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of gene expression and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome and nucleus. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; maxillary process; and telencephalon. Orthologous to human ZNF410 (zinc finger protein 410). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.5), CNS E14 (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp410 in Genome Data Viewer
Location:
12 D1; 12 39.15 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84363615..84391213)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84316510..84344439)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene prostaglandin reductase 2 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene basal body orientation factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Benanti JA, et al. Mol Cell Biol, 2002 Nov. PMID 12370286, Free PMC Article
  2. ZNF410 represses fetal globin by singular control of CHD4. Vinjamur DS, et al. Nat Genet, 2021 May. PMID 33859416, Free PMC Article
  3. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
  4. Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Campbell GR, et al. Mol Cell Neurosci, 2011 Feb. PMID 21194568, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC38535

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 410
Names
another partner for ARF 1
zinc finger protein APA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252582.2 → NP_001239511.1  zinc finger protein 410 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI449605, AK033090, AK051939, BB657543, CK791111, DT918547
    Consensus CDS
    CCDS88369.1
    UniProtKB/Swiss-Prot
    Q8BKX7
    Related
    ENSMUSP00000152441.2, ENSMUST00000222258.2
    Conserved Domains (3) summary
    sd00017
    Location:251 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266 → 292
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:251 → 334
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_001252583.1 → NP_001239512.1  zinc finger protein 410 isoform 3

    See identical proteins and their annotated locations for NP_001239512.1

    Status: VALIDATED

    Source sequence(s)
    BB466060, BC052080, CK791111
    Consensus CDS
    CCDS88368.1
    UniProtKB/Swiss-Prot
    Q8BKX7
    Related
    ENSMUSP00000152098.2, ENSMUST00000220931.2
    Conserved Domains (3) summary
    sd00017
    Location:251 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266 → 292
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:251 → 335
    zf-C2H2_8; C2H2-type zinc ribbon

  3. NM_001364223.1 → NP_001351152.1  zinc finger protein 410 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159649
    Conserved Domains (2) summary
    sd00017
    Location:200 → 220
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:198 → 220
    zf-C2H2; Zinc finger, C2H2 type

  4. NM_001423121.1 → NP_001410050.1  zinc finger protein 410 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159649
    UniProtKB/Swiss-Prot
    Q8BKX7, Q8BWB3, Q8BZZ7, Q8R5L2, Q8VDL2

  5. NM_001423122.1 → NP_001410051.1  zinc finger protein 410 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159649
    UniProtKB/Swiss-Prot
    Q8BKX7, Q8BWB3, Q8BZZ7, Q8R5L2, Q8VDL2

  6. NM_001423123.1 → NP_001410052.1  zinc finger protein 410 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159649

  7. NM_001423124.1 → NP_001410053.1  zinc finger protein 410 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159649

  8. NM_144833.4 → NP_659082.1  zinc finger protein 410 isoform 1

    See identical proteins and their annotated locations for NP_659082.1

    Status: VALIDATED

    Source sequence(s)
    AC159649, AK051939, AK132345, CK791111
    Consensus CDS
    CCDS26042.1
    UniProtKB/Swiss-Prot
    Q8BKX7, Q8BWB3, Q8BZZ7, Q8R5L2, Q8VDL2
    Related
    ENSMUSP00000045550.11, ENSMUST00000045931.12
    Conserved Domains (3) summary
    COG5189
    Location:189 → 300
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:281 → 303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:325 → 350
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_045546.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159649, AK051939, BC056957, CK791111

  2. NR_045615.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159649, AK051939

  3. NR_157102.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159649

  4. NR_157103.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159649

  5. NR_186734.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159649
    Related
    ENSMUST00000222606.2

  6. NR_186735.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159649

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84363615..84391213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKX7.2 GenPept UniProtKB/Swiss-Prot:Q8BKX7

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