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Slc52a2 solute carrier protein 52, member 2 [ Mus musculus (house mouse) ]

Gene ID: 52710, updated on 28-Oct-2024

Summary

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Official Symbol
Slc52a2provided by MGI
Official Full Name
solute carrier protein 52, member 2provided by MGI
Primary source
MGI:MGI:1289288
See related
Ensembl:ENSMUSG00000022560 AllianceGenome:MGI:1289288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAR2; RFT1; Rfvt2; mRFT1; GPCR42; Gpr172b; D15Ertd747e; 2010003P03Rik
Summary
Enables riboflavin transmembrane transporter activity. Involved in flavin adenine dinucleotide biosynthetic process and riboflavin metabolic process. Is active in plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 2 and riboflavin deficiency. Orthologous to several human genes including SLC52A2 (solute carrier family 52 member 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 16.9), small intestine adult (RPKM 12.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc52a2 in Genome Data Viewer
Location:
15 D3; 15 36.04 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76422994..76432078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76538814..76547878)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 249 Neighboring gene STARR-positive B cell enhancer ABC_E3144 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene predicted gene, 35739 Neighboring gene STARR-positive B cell enhancer ABC_E9913 Neighboring gene aarF domain containing kinase 5 Neighboring gene cleavage and polyadenylation specific factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice. Jin C, et al. Biol Pharm Bull, 2021. PMID 33518683
  2. Involvement of riboflavin transporter RFVT2/Slc52a2 in hepatic homeostasis of riboflavin in mice. Yao Y, et al. Eur J Pharmacol, 2013 Aug 15. PMID 23911957
  3. SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation. Intoh A, et al. Hum Mol Genet, 2016 May 1. PMID 26976849, Free PMC Article
  4. Riboflavin uptake transporter Slc52a2 (RFVT2) is upregulated in the mouse mammary gland during lactation. Wu AM, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Apr 1. PMID 26791833
  5. Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice. Jin C, et al. Sci Rep, 2020 Oct 28. PMID 33116204, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice.
    Title: Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice.
  2. mRFVT2 was involved in hepatic riboflavin homeostasis
    Title: Involvement of riboflavin transporter RFVT2/Slc52a2 in hepatic homeostasis of riboflavin in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 
  • Targeted (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4-hydroxybutyrate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables 4-hydroxybutyrate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables riboflavin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables riboflavin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables riboflavin transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in flavin adenine dinucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in flavin adenine dinucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in riboflavin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in riboflavin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in riboflavin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in riboflavin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in riboflavin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
solute carrier family 52, riboflavin transporter, member 2
Names
G protein-coupled receptor 172B
PERV-A receptor 2 homolog
porcine endogenous retrovirus A receptor 2 homolog
riboflavin transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029643.4 → NP_083919.1  solute carrier family 52, riboflavin transporter, member 2

    See identical proteins and their annotated locations for NP_083919.1

    Status: VALIDATED

    Source sequence(s)
    AC157566, AK029579, BY148057
    Consensus CDS
    CCDS27575.1
    UniProtKB/Swiss-Prot
    Q8CCV8, Q9D8F3
    Related
    ENSMUSP00000023220.9, ENSMUST00000023220.10
    Conserved Domains (1) summary
    pfam06237
    Location:282 → 376
    DUF1011; Protein of unknown function (DUF1011)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76422994..76432078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521151.5 → XP_006521214.1  solute carrier family 52, riboflavin transporter, member 2 isoform X1

    See identical proteins and their annotated locations for XP_006521214.1

    UniProtKB/Swiss-Prot
    Q8CCV8, Q9D8F3
    Conserved Domains (1) summary
    pfam06237
    Location:282 → 376
    DUF1011; Protein of unknown function (DUF1011)

RNA

  1. XR_004938852.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8F3.1 GenPept UniProtKB/Swiss-Prot:Q9D8F3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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