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SERPINB10 serpin family B member 10 [ Homo sapiens (human) ]

Gene ID: 5273, updated on 3-Apr-2024

Summary

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Official Symbol
SERPINB10provided by HGNC
Official Full Name
serpin family B member 10provided by HGNC
Primary source
HGNC:HGNC:8942
See related
Ensembl:ENSG00000242550 MIM:602058; AllianceGenome:HGNC:8942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI10; PI-10
Summary
This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward bone marrow (RPKM 23.0) See more
Orthologs
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Genomic context

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Location:
18q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (63907958..63936111)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (64113032..64141170)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61575192..61603345)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene serpin family B member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13469 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:61536385-61537584 Neighboring gene uncharacterized LOC124904356 Neighboring gene serpin family B member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:61607430-61607930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13470 Neighboring gene uncharacterized LOC105372165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9532 Neighboring gene Sharpr-MPRA regulatory region 9998 Neighboring gene histocompatibility minor serpin domain containing Neighboring gene serpin family B member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps. Deng Z, et al. Dis Markers, 2022. PMID 36398030, Free PMC Article
  2. Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma. Zong W, et al. Int Arch Allergy Immunol, 2022. PMID 35526531
  3. SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response. Majoros H, et al. Int J Mol Sci, 2021 Aug 7. PMID 34445206, Free PMC Article
  4. Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment. Przygodzka P, et al. BMC Cell Biol, 2010 Apr 30. PMID 20433722, Free PMC Article
  5. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. Schleef RR, et al. J Biol Chem, 2000 Aug 25. PMID 10871600

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps.
    Title: Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps.
  2. Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma.
    Title: Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma.
  3. SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response.
    Title: SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response.
  4. Epithelial SERPINB10 contributes to allergic airway eosinophilic inflammation, at least in part, by regulating the expression of periostin and CCL26.
    Title: Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation.
  5. DGCR2, GPR44 and SerpinB10, found in beta cells, were negative in all other cell types within pancreas and exposed epitopes at the cell surface
    Title: Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates.
  6. Bomapin is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability.
    Title: Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
serpin B10
Names
bomapin
peptidase inhibitor 10
protease inhibitor 10 (ovalbumin type)
protease inhibitor 10 (ovalbumin type, bomapin)
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10
serpin peptidase inhibitor, clade B (ovalbumin), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005024.3 → NP_005015.1  serpin B10

    See identical proteins and their annotated locations for NP_005015.1

    Status: REVIEWED

    Source sequence(s)
    AA993220, AC009802, AC072051, AK314936, U35459
    Consensus CDS
    CCDS11990.1
    UniProtKB/Swiss-Prot
    P48595, Q4VAX4, Q4VAX7
    UniProtKB/TrEMBL
    Q4VAX6
    Related
    ENSP00000238508.3, ENST00000238508.8
    Conserved Domains (1) summary
    cd19569
    Location:1 → 397
    serpinB10_bomapin; serpin family B member 10, bomapin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    63907958..63936111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526027.2 → XP_011524329.1  serpin B10 isoform X1

    See identical proteins and their annotated locations for XP_011524329.1

    UniProtKB/Swiss-Prot
    P48595, Q4VAX4, Q4VAX7
    UniProtKB/TrEMBL
    Q4VAX6
    Conserved Domains (1) summary
    cd19569
    Location:1 → 397
    serpinB10_bomapin; serpin family B member 10, bomapin

  2. XM_017025793.2 → XP_016881282.1  serpin B10 isoform X2

    UniProtKB/TrEMBL
    Q4VAX6

  3. XM_011526028.1 → XP_011524330.1  serpin B10 isoform X3

    Conserved Domains (1) summary
    cl00137
    Location:1 → 268
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    64113032..64141170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318688.1 → XP_054174663.1  serpin B10 isoform X1

  2. XM_054318689.1 → XP_054174664.1  serpin B10 isoform X2

  3. XM_054318690.1 → XP_054174665.1  serpin B10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48595.1 GenPept UniProtKB/Swiss-Prot:P48595

Gene LinkOut

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