Ldhd lactate dehydrogenase D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ldhdprovided by MGI
Official Full Name: lactate dehydrogenase Dprovided by MGI
Primary source: MGI:MGI:106428
See related: Ensembl:ENSMUSG00000031958 AllianceGenome:MGI:106428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DLD; D8Bwg1320e; 4733401P21Rik
Summary: Predicted to enable D-lactate dehydrogenase (cytochrome) activity; D-lactate dehydrogenase activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in lactate catabolic process. Located in mitochondrion. Orthologous to human LDHD (lactate dehydrogenase D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 169.0), kidney adult (RPKM 153.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 57.98 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (112352250..112356968, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (111625611..111630336, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gout can be caused by a mutation in LDHD within the putative catalytic site of the encoded d-lactate dehydrogenase, resulting in augmented blood levels of d-lactate, a stereoisomer of l-lactate
Title: Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase.
identification and characterization of human and mouse D-lactate dehydrogenase (NAD) [D-LDH]
Title: Identification of putative mammalian D-lactate dehydrogenase enzymes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D8Bwg1320e (e-PCR), detects polymorphism
- UniSTS:142715

MDB1320 (e-PCR)
- UniSTS:125051

Ldhd (e-PCR), detects polymorphism
- UniSTS:507017

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-lactate dehydrogenase (cytochrome) activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-lactate dehydrogenase (cytochrome) activity	IEA Inferred from Electronic Annotation more info
enables D-lactate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-lactate dehydrogenase activity	NAS Non-traceable Author Statement more info	PubMed
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in lactate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lactate catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: probable D-lactate dehydrogenase, mitochondrial

NP_081846.3

EC 1.1.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027570.5 → NP_081846.3 probable D-lactate dehydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_081846.3

Status: VALIDATED

Source sequence(s)

AC122364

Consensus CDS

CCDS22677.1

UniProtKB/Swiss-Prot

Q7TNG8, Q8BYU7, Q8CIV4

UniProtKB/TrEMBL

Q9D635

Related

ENSMUSP00000068086.4, ENSMUST00000070004.4

Conserved Domains (3) summary

COG0277
Location:34 → 484

GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

pfam01565
Location:66 → 202

FAD_binding_4; FAD binding domain

pfam02913
Location:243 → 483

FAD-oxidase_C; FAD linked oxidases, C-terminal domain