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Dnlz DNL-type zinc finger [ Mus musculus (house mouse) ]

Gene ID: 52838, updated on 2-Nov-2024

Summary

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Official Symbol
Dnlzprovided by MGI
Official Full Name
DNL-type zinc fingerprovided by MGI
Primary source
MGI:MGI:106559
See related
Ensembl:ENSMUSG00000075467 AllianceGenome:MGI:106559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HEP1; D2Bwg1335e; 1110034G11Rik
Summary
Predicted to enable protein folding chaperone and protein-folding chaperone binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; protein import into mitochondrial matrix; and protein stabilization. Located in mitochondrion. Orthologous to human DNLZ (DNL-type zinc finger). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.1), CNS E11.5 (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dnlz in Genome Data Viewer
Location:
2 A3; 2 18.87 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26238130..26242122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26348118..26352110, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 187 Neighboring gene predicted gene, 35807 Neighboring gene STARR-seq mESC enhancer starr_03980 Neighboring gene predicted gene, 52505 Neighboring gene G-protein signalling modulator 1 (AGS3-like, C. elegans) Neighboring gene predicted gene 13562 Neighboring gene caspase recruitment domain family, member 9 Neighboring gene small nuclear RNA activating complex, polypeptide 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  2. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNL-type zinc finger protein
Names
hsp70-escort protein 1
mtHsp70-escort protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139503.1 → NP_001132975.1  DNL-type zinc finger protein isoform 2

    See identical proteins and their annotated locations for NP_001132975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) skips an exon in the coding region, compared to variant (1). The encoded protein (isoform 2) has a shorter and distinct C-terminus that lacks a zinc finger DNL domain, compared to isoform 1.
    Source sequence(s)
    AK142070, BC031595
    UniProtKB/TrEMBL
    Q8K0F4
    Related
    ENSMUST00000125848.2

  2. NM_001139504.1 → NP_001132976.1  DNL-type zinc finger protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a frame-shifting alternate splice site in the coding region, compared to variant (1). The encoded protein (isoform 3) has a shorter and distinct C-terminus that lacks a zinc finger DNL domain, compared to isoform 1.
    Source sequence(s)
    AK142070, BC031595, BY266852
    UniProtKB/Swiss-Prot
    Q9D113
    UniProtKB/TrEMBL
    Q8K0F4

  3. NM_026828.3 → NP_081104.1  DNL-type zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_081104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK142070, BC031595
    Consensus CDS
    CCDS38083.1
    UniProtKB/Swiss-Prot
    B2RTG5, Q9D113
    Related
    ENSMUSP00000028295.9, ENSMUST00000028295.9
    Conserved Domains (1) summary
    pfam05180
    Location:74 → 139
    zf-DNL; DNL zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26238130..26242122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D113.1 GenPept UniProtKB/Swiss-Prot:Q9D113

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