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PIGR polymeric immunoglobulin receptor [ Homo sapiens (human) ]

Gene ID: 5284, updated on 3-Nov-2024

Summary

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Official Symbol
PIGRprovided by HGNC
Official Full Name
polymeric immunoglobulin receptorprovided by HGNC
Primary source
HGNC:HGNC:8968
See related
Ensembl:ENSG00000162896 MIM:173880; AllianceGenome:HGNC:8968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Expression
Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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See PIGR in Genome Data Viewer
Location:
1q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206928522..206946466, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206193722..206211683, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207101867..207119811, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:207078063-207079262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene interleukin 24 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2438 Neighboring gene tRNA-Pro (anticodon TGG) 5-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. In vitro refolding of recombinant human free secretory component using equilibrium gradient dialysis. Prinsloo E, et al. Protein Expr Purif, 2006 May. PMID 16288892
  2. The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor. Braathen R, et al. J Biol Chem, 2002 Nov 8. PMID 12213814
  3. Secretory component is cleaved by neutrophil serine proteinases but its epithelial production is increased by neutrophils through NF-kappa B- and p38 mitogen-activated protein kinase-dependent mechanisms. Pilette C, et al. Am J Respir Cell Mol Biol, 2003 Apr. PMID 12654638
  4. Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients. Obara W, et al. J Hum Genet, 2003. PMID 12740691
  5. The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. Lu L, et al. J Biol Chem, 2003 Nov 28. PMID 13679368

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
    Title: SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
  2. Polymeric immunoglobulin receptor (pIgR) in cancer.
    Title: Polymeric immunoglobulin receptor (pIgR) in cancer.
  3. Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.
    Title: Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.
  4. Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
    Title: Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
  5. Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
    Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
  6. M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1beta.
    Title: M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.
  7. Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
    Title: Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
  8. Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
    Title: Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
  9. A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression.
    Title: A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression.
  10. High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.
    Title: High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22667, MGC125361, MGC125362

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables polymeric immunoglobulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables polymeric immunoglobulin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Fc receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor clustering IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of secretory IgA immunoglobulin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polymeric immunoglobulin receptor
Names
hepatocellular carcinoma associated protein TB6
poly-Ig receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012927.1 RefSeqGene

    Range
    5001..22945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002644.4 → NP_002635.2  polymeric immunoglobulin receptor precursor

    See identical proteins and their annotated locations for NP_002635.2

    Status: REVIEWED

    Source sequence(s)
    AF272149, AK225471
    Consensus CDS
    CCDS1474.1
    UniProtKB/Swiss-Prot
    P01833, Q68D81, Q8IZY7
    Related
    ENSP00000348888.4, ENST00000356495.5
    Conserved Domains (1) summary
    cd05716
    Location:464 → 560
    IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206928522..206946466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509629.2 → XP_011507931.1  polymeric immunoglobulin receptor isoform X1

    See identical proteins and their annotated locations for XP_011507931.1

    UniProtKB/Swiss-Prot
    P01833, Q68D81, Q8IZY7
    Conserved Domains (1) summary
    cd05716
    Location:464 → 560
    IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206193722..206211683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337031.1 → XP_054193006.1  polymeric immunoglobulin receptor isoform X1

    UniProtKB/Swiss-Prot
    P01833, Q68D81, Q8IZY7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01833.4 GenPept UniProtKB/Swiss-Prot:P01833

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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