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Corin corin, serine peptidase [ Mus musculus (house mouse) ]

Gene ID: 53419, updated on 2-Nov-2024

Summary

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Official Symbol
Corinprovided by MGI
Official Full Name
corin, serine peptidaseprovided by MGI
Primary source
MGI:MGI:1349451
See related
Ensembl:ENSMUSG00000005220 AllianceGenome:MGI:1349451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrp4
Summary
Enables serine-type endopeptidase activity. Involved in several processes, including peptide hormone processing; regulation of renal sodium excretion; and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Located in cell surface. Is expressed in several structures, including floor plate; heart; jaw; phalanx; and skin. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 20.3), testis adult (RPKM 3.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Corin in Genome Data Viewer
Location:
5 C3.2; 5 38.44 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72457291..72661884, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72299948..72504540, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:72551776-72552076 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72559343-72559644 Neighboring gene STARR-positive B cell enhancer ABC_E670 Neighboring gene COMM domain containing 8 Neighboring gene STARR-seq mESC enhancer starr_13361 Neighboring gene STARR-seq mESC enhancer starr_13362 Neighboring gene STARR-seq mESC enhancer starr_13363 Neighboring gene STARR-positive B cell enhancer ABC_E10323 Neighboring gene ATPase, class V, type 10D Neighboring gene STARR-positive B cell enhancer ABC_E4761 Neighboring gene predicted gene, 25768 Neighboring gene STARR-seq mESC enhancer starr_13364 Neighboring gene synaptonemal complex central element protein 2 pseudogene Neighboring gene predicted gene, 23712 Neighboring gene STARR-seq mESC enhancer starr_13365 Neighboring gene STARR-seq mESC enhancer starr_13366 Neighboring gene nuclear transcription factor, X-box binding-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72950846-72951147 Neighboring gene predicted gene, 34144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Corin protects against acute kidney injury in mice through anti-inflammatory effects. Sun M, et al. Biomed Pharmacother, 2024 Feb. PMID 38246101
  2. A novel cytoplasmic tail motif regulates mouse corin expression on the cell surface. Li H, et al. Biochem Biophys Res Commun, 2015 Sep 11. PMID 26241673, Free PMC Article
  3. Increases in plasma corin levels following experimental myocardial infarction reflect the severity of ischemic injury. Wang D, et al. PLoS One, 2018. PMID 30192780, Free PMC Article
  4. Corin overexpression improves cardiac function, heart failure, and survival in mice with dilated cardiomyopathy. Gladysheva IP, et al. Hypertension, 2013 Feb. PMID 23232642, Free PMC Article
  5. Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia. Baird RC, et al. Can J Cardiol, 2019 Jan. PMID 30595185, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Corin protects against acute kidney injury in mice through anti-inflammatory effects.
    Title: Corin protects against acute kidney injury in mice through anti-inflammatory effects.
  2. Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium.
    Title: Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium.
  3. Overexpression of Corin Ameliorates Kidney Fibrosis through Inhibition of Wnt/beta-Catenin Signaling in Mice.
    Title: Overexpression of Corin Ameliorates Kidney Fibrosis through Inhibition of Wnt/β-Catenin Signaling in Mice.
  4. Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis.
    Title: Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis.
  5. A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.
    Title: A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.
  6. Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death.
    Title: Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death.
  7. Kruppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
    Title: Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
  8. The protective effects of cardiac corin on HF progression and survival in experimental DCM do not require the serine protease activity of the molecule.
    Title: Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy.
  9. This is the first study to show that corin is a key regulator of bone development by modulation of VEGF-A expression.
    Title: Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression.
  10. In mice, corin deficiency causes cardiac hypertrophy during pregnancy. Replacement of cardiac WT corin, but not the T555I/Q568P variant found in blacks, rescues this phenotype, indicating a local antihypertrophic function of corin in the heart. Corin deficiency may represent an underlying mechanism in preeclampsia-associated cardiomyopathies.
    Title: Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118735

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in female pregnancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in peptide hormone processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
atrial natriuretic peptide-converting enzyme
Names
low density lipoprotein receptor-related protein 4
low density lipoprotein-related protein 4
pro-ANP-converting enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122756.2 → NP_001116228.1  atrial natriuretic peptide-converting enzyme isoform 2

    See identical proteins and their annotated locations for NP_001116228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC129608, AC161529
    Consensus CDS
    CCDS51513.1
    UniProtKB/TrEMBL
    H3BLB2
    Related
    ENSMUSP00000127389.3, ENSMUST00000167460.9
    Conserved Domains (7) summary
    cd07445
    Location:136 → 265
    CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    cd07888
    Location:456 → 577
    CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    smart00020
    Location:802 → 1031
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:692 → 787
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:657 → 691
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:803 → 1034
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00057
    Location:582 → 616
    Ldl_recept_a; Low-density lipoprotein receptor domain class A

  2. NM_001421227.1 → NP_001408156.1  atrial natriuretic peptide-converting enzyme isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129608, AC161529

  3. NM_016869.4 → NP_058565.2  atrial natriuretic peptide-converting enzyme isoform 1

    See identical proteins and their annotated locations for NP_058565.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC129608, AC161529
    Consensus CDS
    CCDS19330.1
    UniProtKB/Swiss-Prot
    B2RRC6, Q566K6, Q9Z319
    UniProtKB/TrEMBL
    B7ZNH6
    Related
    ENSMUSP00000005352.4, ENSMUST00000005352.10
    Conserved Domains (7) summary
    cd07445
    Location:202 → 331
    CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    cd07888
    Location:522 → 643
    CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    smart00020
    Location:868 → 1097
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:758 → 853
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:723 → 757
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:869 → 1100
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00057
    Location:648 → 682
    Ldl_recept_a; Low-density lipoprotein receptor domain class A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    72457291..72661884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240755.1 → XP_011239057.1  atrial natriuretic peptide-converting enzyme isoform X1

    UniProtKB/TrEMBL
    H3BKS9
    Conserved Domains (6) summary
    cd07445
    Location:136 → 264
    CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    cd07888
    Location:455 → 576
    CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    smart00202
    Location:691 → 786
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:656 → 690
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:802 → 1033
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00057
    Location:581 → 615
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z319.2 GenPept UniProtKB/Swiss-Prot:Q9Z319

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