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Syt5 synaptotagmin V [ Mus musculus (house mouse) ]

Gene ID: 53420, updated on 2-Nov-2024

Summary

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Official Symbol
Syt5provided by MGI
Official Full Name
synaptotagmin Vprovided by MGI
Primary source
MGI:MGI:1926368
See related
Ensembl:ENSMUSG00000004961 AllianceGenome:MGI:1926368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SytV
Summary
Enables SNARE binding activity; phospholipid binding activity; and protein heterodimerization activity. Involved in regulation of calcium ion-dependent exocytosis. Located in several cellular components, including dense core granule; neuronal cell body; and proximal neuron projection. Is active in neuronal dense core vesicle membrane. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human SYT5 (synaptotagmin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 33.6), cortex adult (RPKM 29.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Syt5 in Genome Data Viewer
Location:
7 A1; 7 2.62 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4542764..4550540, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4539765..4547541, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4461475-4461662 Neighboring gene troponin T1, skeletal, slow Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3 Neighboring gene protein tyrosine phosphatase receptor type H Neighboring gene predicted gene 9463

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The exocytosis regulator synaptotagmin V controls phagocytosis in macrophages. Vinet AF, et al. J Immunol, 2008 Oct 15. PMID 18832684
  2. Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. Gustavsson N, et al. PLoS One, 2010 Nov 9. PMID 21085706, Free PMC Article
  3. Synaptotagmin V is targeted to dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells. Saegusa C, et al. J Biol Chem, 2002 Jul 5. PMID 12006594
  4. Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9. Roper LK, et al. Nat Commun, 2015 Oct 20. PMID 26482442, Free PMC Article
  5. Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location. Craxton M, et al. Genomics, 1997 May 15. PMID 9177789

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SYT7 and SYTL5 were positive regulators of chemotaxis
    Title: Synaptotagmin-mediated vesicle fusion regulates cell migration.
  2. focal exocytosis of endocytic organelles is a key event in phagocytosis and suggest that Syt V regulates this process.
    Title: The exocytosis regulator synaptotagmin V controls phagocytosis in macrophages.
  3. Synaptotagmin IX regulates the transport of certain vesicles in the brain other than synaptic vesicles.
    Title: Distinct developmental expression of synaptotagmin I and IX in the mouse brain.
  4. Anatomical distribution and functional properties of this synaptotagmin protein are revealed by conditional knock-out mice engineered to express a GFP tag introduced at the start of the first coding exon of this gene locus.
    Title: Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding TAS
Traceable Author Statement
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dense core granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal dense core vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal dense core vesicle membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in proximal neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
synaptotagmin-5
Names
synaptotagmin IX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360421.1 → NP_001347350.1  synaptotagmin-5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS20738.1
    UniProtKB/Swiss-Prot
    Q9R0N5
    Related
    ENSMUSP00000070322.6, ENSMUST00000065957.7
    Conserved Domains (2) summary
    cl14603
    Location:240 → 374
    C2; C2 domain
    cl28120
    Location:3 → 64
    Herpes_gI; Alphaherpesvirus glycoprotein I

  2. NM_001360422.1 → NP_001347351.1  synaptotagmin-5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS20738.1
    UniProtKB/Swiss-Prot
    Q9R0N5
    Conserved Domains (2) summary
    cl14603
    Location:240 → 374
    C2; C2 domain
    cl28120
    Location:3 → 64
    Herpes_gI; Alphaherpesvirus glycoprotein I

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4542764..4550540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016908.2: Suppressed sequence

    Description
    NM_016908.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0N5.1 GenPept UniProtKB/Swiss-Prot:Q9R0N5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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