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Clasrp CLK4-associating serine/arginine rich protein [ Mus musculus (house mouse) ]

Gene ID: 53609, updated on 2-Nov-2024

Summary

Official Symbol
Clasrpprovided by MGI
Official Full Name
CLK4-associating serine/arginine rich proteinprovided by MGI
Primary source
MGI:MGI:1855695
See related
Ensembl:ENSMUSG00000061028 AllianceGenome:MGI:1855695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clasp; Swap2; Sfrs16; Srsf16
Summary
The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in adrenal adult (RPKM 41.1), limb E14.5 (RPKM 37.2) and 28 other tissues See more
Orthologs
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Genomic context

See Clasrp in Genome Data Viewer
Location:
7 A3; 7 9.93 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19314963..19338442, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19581038..19604517, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18207 Neighboring gene gem nuclear organelle associated protein 7 Neighboring gene zinc finger protein 296 Neighboring gene avian reticuloendotheliosis viral (v-rel) oncogene related B Neighboring gene STARR-positive B cell enhancer ABC_E1720 Neighboring gene cleft lip and palate associated transmembrane protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4901

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118002

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CLK4-associating serine/arginine rich protein
Names
Clk4 associating SR-related protein
serine/arginine-rich splicing factor 16
splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)
suppressor of white-apricot homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016680.5NP_057889.3  CLK4-associating serine/arginine rich protein

    See identical proteins and their annotated locations for NP_057889.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (L, PMID:12169693) represents the shortest transcript and encodes the protein.
    Source sequence(s)
    BC051916, BC060092, CJ146179
    Consensus CDS
    CCDS52061.1
    UniProtKB/Swiss-Prot
    Q5RKW4, Q8CFC7, Q8CFC8, Q9Z2N3
    Related
    ENSMUSP00000083205.6, ENSMUST00000086041.7
    Conserved Domains (1) summary
    pfam09750
    Location:41169
    DRY_EERY; Alternative splicing regulator

RNA

  1. NR_125832.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (S, PMID: 12169693) uses an alternate splice site in an internal exon, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC051916, BC060092, CJ146179
    Related
    ENSMUST00000208068.2
  2. NR_125833.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in its internal exons, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC051916, BC060092, BC103781, BY591198, CJ146179
    Related
    ENSMUST00000207524.2
  3. NR_125834.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon segment, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK009334, BC051916, BC060092, CJ146179
  4. NR_125835.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon and contains an alternate internal exon segment, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF042799, BC060092
    Related
    ENSMUST00000207907.2
  5. NR_125836.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in its internal exons, compared to variant L. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant L, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC060092, BC103781, CJ146179
    Related
    ENSMUST00000207663.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19314963..19338442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242772.1XP_030098632.1  CLK4-associating serine/arginine rich protein isoform X3

    Conserved Domains (1) summary
    pfam09750
    Location:41169
    DRY_EERY; Alternative splicing regulator
  2. XM_011250629.1XP_011248931.1  CLK4-associating serine/arginine rich protein isoform X2

    Conserved Domains (1) summary
    pfam09750
    Location:41169
    DRY_EERY; Alternative splicing regulator
  3. XM_017322361.1XP_017177850.1  CLK4-associating serine/arginine rich protein isoform X1

    Conserved Domains (1) summary
    pfam09750
    Location:41169
    DRY_EERY; Alternative splicing regulator
  4. XM_036153245.1XP_036009138.1  CLK4-associating serine/arginine rich protein isoform X8

  5. XM_017322362.3XP_017177851.1  CLK4-associating serine/arginine rich protein isoform X7

  6. XM_030242774.1XP_030098634.1  CLK4-associating serine/arginine rich protein isoform X5

    Conserved Domains (1) summary
    pfam09750
    Location:4107
    DRY_EERY; Alternative splicing regulator
  7. XM_030242773.1XP_030098633.1  CLK4-associating serine/arginine rich protein isoform X4

    Conserved Domains (1) summary
    pfam09750
    Location:4107
    DRY_EERY; Alternative splicing regulator
  8. XM_030242778.1XP_030098638.1  CLK4-associating serine/arginine rich protein isoform X7

  9. XM_030242779.1XP_030098639.1  CLK4-associating serine/arginine rich protein isoform X8

  10. XM_030242776.1XP_030098636.1  CLK4-associating serine/arginine rich protein isoform X7

  11. XM_036153242.1XP_036009135.1  CLK4-associating serine/arginine rich protein isoform X7

  12. XM_030242775.2XP_030098635.1  CLK4-associating serine/arginine rich protein isoform X6

    Conserved Domains (1) summary
    pfam09750
    Location:573
    DRY_EERY; Alternative splicing regulator
  13. XM_036153244.1XP_036009137.1  CLK4-associating serine/arginine rich protein isoform X8

  14. XM_036153241.1XP_036009134.1  CLK4-associating serine/arginine rich protein isoform X7

  15. XM_006540191.5XP_006540254.1  CLK4-associating serine/arginine rich protein isoform X1

    Conserved Domains (1) summary
    pfam09750
    Location:41169
    DRY_EERY; Alternative splicing regulator
  16. XM_036153243.1XP_036009136.1  CLK4-associating serine/arginine rich protein isoform X7

  17. XM_017322363.1XP_017177852.1  CLK4-associating serine/arginine rich protein isoform X7

  18. XM_036153246.1XP_036009139.1  CLK4-associating serine/arginine rich protein isoform X8

RNA

  1. XR_004934146.1 RNA Sequence

  2. XR_003946516.1 RNA Sequence

  3. XR_004934145.1 RNA Sequence

  4. XR_003946514.2 RNA Sequence

  5. XR_003946517.2 RNA Sequence

  6. XR_004934148.1 RNA Sequence

  7. XR_004934147.1 RNA Sequence