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Septin9 septin 9 [ Mus musculus (house mouse) ]

Gene ID: 53860, updated on 2-Nov-2024

Summary

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Official Symbol
Septin9provided by MGI
Official Full Name
septin 9provided by MGI
Primary source
MGI:MGI:1858222
See related
Ensembl:ENSMUSG00000059248 AllianceGenome:MGI:1858222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msf; MSF1; Sept9; Sint1; PNUTL4
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Part of septin complex. Is expressed in several structures, including branchial arch; embryo ectoderm; embryo mesenchyme; inner ear; and integumental system. Human ortholog(s) of this gene implicated in brachial plexus neuritis and colorectal cancer. Orthologous to human SEPTIN9 (septin 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 25.9), thymus adult (RPKM 24.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Septin9 in Genome Data Viewer
Location:
11 E2; 11 82.61 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117090487..117253151)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117199661..117362325)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9848 Neighboring gene predicted gene 11730 Neighboring gene SEC14-like lipid binding 1 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117127061-117127170 Neighboring gene predicted gene, 39478 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117153788-117154073 Neighboring gene STARR-seq mESC enhancer starr_31245 Neighboring gene STARR-positive B cell enhancer ABC_E4019 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117181442-117181643 Neighboring gene STARR-positive B cell enhancer ABC_E8473 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117187354-117187555 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117195481-117195819 Neighboring gene VISTA enhancer mm1309 Neighboring gene predicted gene, 34065 Neighboring gene STARR-positive B cell enhancer ABC_E3041 Neighboring gene predicted gene, 34128 Neighboring gene predicted gene 11729

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family. Sørensen AB, et al. J Virol, 2000 Mar. PMID 10666245, Free PMC Article
  2. Alternative splicing, expression, and gene structure of the septin-like putative proto-oncogene Sint1. Sørensen AB, et al. Gene, 2002 Feb 20. PMID 12039034
  3. Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Lassen LB, et al. Cell Tissue Res, 2013 Jun. PMID 23644740
  4. MiR-503-5p alleviates peripheral neuropathy-induced neuropathic pain in T2DM mice by regulating SEPT9 to inhibit astrocyte activation. Guo Y, et al. Sci Rep, 2024 Jun 21. PMID 38906977, Free PMC Article
  5. Septin9 is involved in septin filament formation and cellular stability. Füchtbauer A, et al. Biol Chem, 2011 Aug. PMID 21824004

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-503-5p alleviates peripheral neuropathy-induced neuropathic pain in T2DM mice by regulating SEPT9 to inhibit astrocyte activation.
    Title: MiR-503-5p alleviates peripheral neuropathy-induced neuropathic pain in T2DM mice by regulating SEPT9 to inhibit astrocyte activation.
  2. Septin 9 controls CCNB1 stabilization via APC/C[CDC20] during meiotic metaphase I/anaphase I transition in mouse oocytes.
    Title: Septin 9 controls CCNB1 stabilization via APC/C(CDC20) during meiotic metaphase I/anaphase I transition in mouse oocytes.
  3. CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
    Title: CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
  4. observations suggested that Sept9 contributed to alleviate liver fibrosis might partially through promoting activated HSCs apoptosis and this anti-fibrogenesis effect might be blocked by DNMT-3a mediated methylation of Sept9
    Title: Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis.
  5. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.
    Title: Septin9 is involved in T-cell development and CD8+ T-cell homeostasis.
  6. SEPT9 gene amplification and overexpression during mouse breast tumorigenesis
    Title: Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression.
  7. Data reveal the importance of Sept9 for septin filament formation and general cell stability.
    Title: Septin9 is involved in septin filament formation and cellular stability.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in non-motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
septin-9
Names
MLL septin-like fusion
SL3-3 integration site 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113486.1 → NP_001106958.1  septin-9 isoform a

    See identical proteins and their annotated locations for NP_001106958.1

    Status: VALIDATED

    Source sequence(s)
    AK122415, AK141312, AL645975, AW538697
    Consensus CDS
    CCDS48990.1
    UniProtKB/Swiss-Prot
    A2A6U2, A2A6U4, A2A6U6, Q3URP2, Q80TM7, Q80UG5, Q9QYX9
    Related
    ENSMUSP00000091435.5, ENSMUST00000093907.11
    Conserved Domains (2) summary
    cd01850
    Location:293 → 567
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:275 → 580
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  2. NM_001113487.1 → NP_001106959.1  septin-9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AK122415, AW538697, BU148654
    Consensus CDS
    CCDS48991.1
    UniProtKB/Swiss-Prot
    Q80UG5
    Related
    ENSMUSP00000019038.9, ENSMUST00000019038.15
    Conserved Domains (2) summary
    cd01850
    Location:286 → 560
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:268 → 573
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  3. NM_001113488.1 → NP_001106960.1  septin-9 isoform c

    See identical proteins and their annotated locations for NP_001106960.1

    Status: VALIDATED

    Source sequence(s)
    AK031757, AK122415, AW538697, BY035742, BY772945
    Consensus CDS
    CCDS25684.1
    UniProtKB/TrEMBL
    Q3TDR9
    Related
    ENSMUSP00000101956.2, ENSMUST00000106349.2
    Conserved Domains (1) summary
    cd01850
    Location:44 → 318
    CDC_Septin; CDC/Septin GTPase family

  4. NM_017380.2 → NP_059076.1  septin-9 isoform c

    See identical proteins and their annotated locations for NP_059076.1

    Status: VALIDATED

    Source sequence(s)
    AJ250723, AK031757, AW538697, BU612221
    Consensus CDS
    CCDS25684.1
    UniProtKB/TrEMBL
    Q3TDR9
    Related
    ENSMUSP00000097767.2, ENSMUST00000100193.8
    Conserved Domains (1) summary
    cd01850
    Location:44 → 318
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117090487..117253151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533744.3 → XP_006533807.1  septin-9 isoform X1

    UniProtKB/TrEMBL
    A2A6U3
    Related
    ENSMUSP00000101961.3, ENSMUST00000106354.9
    Conserved Domains (2) summary
    cd01850
    Location:275 → 549
    CDC_Septin; CDC/Septin GTPase family
    PHA03247
    Location:20 → 214
    PHA03247; large tegument protein UL36; Provisional

  2. XM_006533746.5 → XP_006533809.1  septin-9 isoform X2

    See identical proteins and their annotated locations for XP_006533809.1

    UniProtKB/TrEMBL
    Q3TDR9
    Conserved Domains (1) summary
    cd01850
    Location:44 → 318
    CDC_Septin; CDC/Septin GTPase family

  3. XM_030246153.2 → XP_030102013.1  septin-9 isoform X2

    UniProtKB/TrEMBL
    Q3TDR9
    Conserved Domains (1) summary
    cd01850
    Location:44 → 318
    CDC_Septin; CDC/Septin GTPase family

  4. XM_030246154.1 → XP_030102014.1  septin-9 isoform X2

    UniProtKB/TrEMBL
    Q3TDR9
    Conserved Domains (1) summary
    cd01850
    Location:44 → 318
    CDC_Septin; CDC/Septin GTPase family

  5. XM_006533745.5 → XP_006533808.2  septin-9 isoform X2

    See identical proteins and their annotated locations for XP_006533808.2

    UniProtKB/TrEMBL
    Q3TDR9
    Conserved Domains (1) summary
    cd01850
    Location:44 → 318
    CDC_Septin; CDC/Septin GTPase family

  6. XM_036156849.1 → XP_036012742.1  septin-9 isoform X2

    UniProtKB/TrEMBL
    Q3TDR9
    Conserved Domains (1) summary
    cd01850
    Location:44 → 318
    CDC_Septin; CDC/Septin GTPase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UG5.1 GenPept UniProtKB/Swiss-Prot:Q80UG5

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