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SLC37A1 solute carrier family 37 member 1 [ Homo sapiens (human) ]

Gene ID: 54020, updated on 11-Apr-2024

Summary

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Official Symbol
SLC37A1provided by HGNC
Official Full Name
solute carrier family 37 member 1provided by HGNC
Primary source
HGNC:HGNC:11024
See related
Ensembl:ENSG00000160190 MIM:608094; AllianceGenome:HGNC:11024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G3PP; SPX1
Summary
The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Broad expression in duodenum (RPKM 9.6), small intestine (RPKM 8.6) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
21q22.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (42499622..42581426)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (40889339..40971074)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43919732..44001536)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18521 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43912470-43913669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13345 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43919416-43919916 Neighboring gene radial spoke head component 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43932366-43933088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43933089-43933811 Neighboring gene RSPH1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43940701-43941202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43941203-43941702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18523 Neighboring gene uncharacterized LOC107987299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43960552-43961217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43962233-43963163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43965367-43965904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43965905-43966440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43985802-43986722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43991832-43992575 Neighboring gene uncharacterized LOC101928212 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13349 Neighboring gene VISTA enhancer hs2248 Neighboring gene MPRA-validated peak4415 silencer Neighboring gene long intergenic non-protein coding RNA 1671 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44037913-44038824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44057507-44058403 Neighboring gene uncharacterized LOC101928255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44072695-44073416 Neighboring gene phosphodiesterase 9A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. Bartoloni L, et al. Genomics, 2000 Dec 1. PMID 11112347
  2. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. Pan CJ, et al. PLoS One, 2011. PMID 21949678, Free PMC Article
  3. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Carroll JS, et al. Cell, 2005 Jul 15. PMID 16009131
  4. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. Pope SN, et al. J Steroid Biochem Mol Biol, 2005 Feb. PMID 15862967
  5. Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. Liu H, et al. J Pathol, 2019 Aug. PMID 30945288

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glucose 6-phosphate:phosphate antiporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose 6-phosphate:phosphate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose-6-phosphate transport TAS
Traceable Author Statement
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
glucose-6-phosphate exchanger SLC37A1
Names
G-3-P permease
G-3-P transporter
glycerol-3-phosphate permease
glycerol-3-phosphate transporter
solute carrier family 37 (glucose-6-phosphate transporter), member 1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
sugar-phosphate exchange protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033931.1 RefSeqGene

    Range
    4991..86795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320537.2 → NP_001307466.1  glucose-6-phosphate exchanger SLC37A1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is inferred to be translated from a downstream start codon via ribosomal leaky scanning. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF311320, AP001625, BI912541, BM550728, DA755019
    Consensus CDS
    CCDS13689.1
    UniProtKB/Swiss-Prot
    D3DSJ7, P57057, Q9HAQ1
    Related
    ENSP00000344648.2, ENST00000352133.3
    Conserved Domains (2) summary
    cd06174
    Location:98 → 513
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:20 → 519
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  2. NM_018964.4 → NP_061837.3  glucose-6-phosphate exchanger SLC37A1

    See identical proteins and their annotated locations for NP_061837.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ269529, AL355683, AP001625, AW466890, BI912541
    Consensus CDS
    CCDS13689.1
    UniProtKB/Swiss-Prot
    D3DSJ7, P57057, Q9HAQ1
    Related
    ENSP00000381383.3, ENST00000398341.7
    Conserved Domains (2) summary
    cd06174
    Location:98 → 513
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:20 → 519
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    42499622..42581426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440843.1 → XP_047296799.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

  2. XM_017028379.2 → XP_016883868.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    UniProtKB/Swiss-Prot
    D3DSJ7, P57057, Q9HAQ1
    Conserved Domains (2) summary
    cd06174
    Location:98 → 513
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:20 → 519
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  3. XM_047440842.1 → XP_047296798.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

  4. XM_017028377.2 → XP_016883866.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    UniProtKB/Swiss-Prot
    D3DSJ7, P57057, Q9HAQ1
    Conserved Domains (2) summary
    cd06174
    Location:98 → 513
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:20 → 519
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  5. XM_017028381.2 → XP_016883870.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

  6. XM_047440845.1 → XP_047296801.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

  7. XM_047440849.1 → XP_047296805.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    UniProtKB/Swiss-Prot
    D3DSJ7, P57057, Q9HAQ1

  8. XM_047440844.1 → XP_047296800.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

  9. XM_017028380.2 → XP_016883869.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    UniProtKB/Swiss-Prot
    D3DSJ7, P57057, Q9HAQ1
    Conserved Domains (2) summary
    cd06174
    Location:98 → 513
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:20 → 519
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  10. XM_047440850.1 → XP_047296806.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

  11. XM_047440846.1 → XP_047296802.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  12. XM_047440848.1 → XP_047296804.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  13. XM_017028383.2 → XP_016883872.2  glucose-6-phosphate exchanger SLC37A1 isoform X4

  14. XM_047440847.1 → XP_047296803.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  15. XM_011529614.4 → XP_011527916.1  glucose-6-phosphate exchanger SLC37A1 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:129 → 489
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:51 → 543
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  16. XM_011529615.3 → XP_011527917.1  glucose-6-phosphate exchanger SLC37A1 isoform X3

    Conserved Domains (2) summary
    cd06174
    Location:129 → 544
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG2271
    Location:51 → 550
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

  17. XM_017028376.3 → XP_016883865.1  glucose-6-phosphate exchanger SLC37A1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    40889339..40971074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324574.1 → XP_054180549.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

  2. XM_054324585.1 → XP_054180560.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

  3. XM_054324589.1 → XP_054180564.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

  4. XM_054324579.1 → XP_054180554.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  5. XM_054324586.1 → XP_054180561.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

  6. XM_054324590.1 → XP_054180565.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

  7. XM_054324580.1 → XP_054180555.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  8. XM_054324587.1 → XP_054180562.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

  9. XM_054324575.1 → XP_054180550.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

  10. XM_054324576.1 → XP_054180551.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

  11. XM_054324588.1 → XP_054180563.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

  12. XM_054324582.1 → XP_054180557.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  13. XM_054324583.1 → XP_054180558.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  14. XM_054324581.1 → XP_054180556.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

  15. XM_054324577.1 → XP_054180552.1  glucose-6-phosphate exchanger SLC37A1 isoform X2

  16. XM_054324578.1 → XP_054180553.1  glucose-6-phosphate exchanger SLC37A1 isoform X3

  17. XM_054324584.1 → XP_054180559.1  glucose-6-phosphate exchanger SLC37A1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57057.2 GenPept UniProtKB/Swiss-Prot:P57057

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