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PNLIPRP1 pancreatic lipase related protein 1 [ Homo sapiens (human) ]

Gene ID: 5407, updated on 11-Apr-2024

Summary

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Official Symbol
PNLIPRP1provided by HGNC
Official Full Name
pancreatic lipase related protein 1provided by HGNC
Primary source
HGNC:HGNC:9156
See related
Ensembl:ENSG00000187021 MIM:604422; AllianceGenome:HGNC:9156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLRP1
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward pancreas (RPKM 974.1) See more
Orthologs
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Genomic context

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See PNLIPRP1 in Genome Data Viewer
Location:
10q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116590959..116609175)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117485016..117503281)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118350471..118368687)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pancreatic lipase Neighboring gene pancreatic lipase pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:118347975-118348179 Neighboring gene uncharacterized LOC124902510 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene sperm microtubule inner protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. Berton A, et al. Mol Nutr Food Res, 2009 Dec. PMID 19824014
  2. Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Zhang G, et al. Clin Cancer Res, 2013 Sep 15. PMID 23918603, Free PMC Article
  3. Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. Giller T, et al. J Biol Chem, 1992 Aug 15. PMID 1379598
  4. Genome-wide association study of proneness to anger. Mick E, et al. PLoS One, 2014. PMID 24489884, Free PMC Article
  5. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. Fu GK, et al. Genomics, 2004 Jul. PMID 15203218

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pancreatic lipase and its related proteins: where are we now?
    Title: Pancreatic lipase and its related proteins: where are we now?
  2. Low PNLIPRP1 expression is associated with pancreatic cancer.
    Title: Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of proneness to anger.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables triglyceride lipase activity TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
NOT located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inactive pancreatic lipase-related protein 1
NP_001290064.1
NP_006220.1
XP_047281320.1
XP_054189084.1
XP_054222092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303135.1 → NP_001290064.1  inactive pancreatic lipase-related protein 1 precursor

    See identical proteins and their annotated locations for NP_001290064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK130236, BC025784, BP323340, CD622211
    Consensus CDS
    CCDS7595.1
    UniProtKB/Swiss-Prot
    P54315, Q68D83, Q68DR6, Q8TAU2, Q9BS82
    UniProtKB/TrEMBL
    E9PRT6
    Related
    ENSP00000433933.1, ENST00000528052.5
    Conserved Domains (3) summary
    cd00707
    Location:52 → 349
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:356 → 467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18 → 353
    Lipase; Lipase

  2. NM_006229.4 → NP_006220.1  inactive pancreatic lipase-related protein 1 precursor

    See identical proteins and their annotated locations for NP_006220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC005233, BC025784, CD622211, M93283
    Consensus CDS
    CCDS7595.1
    UniProtKB/Swiss-Prot
    P54315, Q68D83, Q68DR6, Q8TAU2, Q9BS82
    UniProtKB/TrEMBL
    E9PRT6
    Related
    ENSP00000351695.4, ENST00000358834.9
    Conserved Domains (3) summary
    cd00707
    Location:52 → 349
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:356 → 467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18 → 353
    Lipase; Lipase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    116590959..116609175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425364.1 → XP_047281320.1  inactive pancreatic lipase-related protein 1 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791790.1 Reference GRCh38.p14 PATCHES

    Range
    1955..20171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333109.1 → XP_054189084.1  inactive pancreatic lipase-related protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    117485016..117503281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366117.1 → XP_054222092.1  inactive pancreatic lipase-related protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54315.1 GenPept UniProtKB/Swiss-Prot:P54315

Gene LinkOut

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