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Gipc2 GIPC PDZ domain containing family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 54120, updated on 2-Nov-2024

Summary

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Official Symbol
Gipc2provided by MGI
Official Full Name
GIPC PDZ domain containing family, member 2provided by MGI
Primary source
MGI:MGI:1889209
See related
Ensembl:ENSMUSG00000039131 AllianceGenome:MGI:1889209
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Semcap2; 2200002N01Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be located in cytoplasm. Is expressed in several structures, including brain; gut; liver; lung; and metanephros. Orthologous to human GIPC2 (GIPC PDZ domain containing family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 43.0), placenta adult (RPKM 43.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Gipc2 in Genome Data Viewer
Location:
3 H3; 3 76.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151799476..151871537, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152093839..152165900, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31739 Neighboring gene STARR-seq mESC enhancer starr_09277 Neighboring gene VISTA enhancer mm2010 Neighboring gene STARR-seq mESC enhancer starr_09278 Neighboring gene STARR-seq mESC enhancer starr_09279 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene Neighboring gene predicted gene, 31881 Neighboring gene predicted gene, 40179 Neighboring gene STARR-seq mESC enhancer starr_09281 Neighboring gene STARR-seq mESC enhancer starr_09282 Neighboring gene STARR-seq mESC enhancer starr_09283 Neighboring gene DnaJ heat shock protein family (Hsp40) member B4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:151866980-151867163 Neighboring gene STARR-positive B cell enhancer ABC_E2101 Neighboring gene predicted gene, 40180 Neighboring gene STARR-seq mESC enhancer starr_09284 Neighboring gene far upstream element (FUSE) binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells. La Torre A, et al. Stem Cells, 2015 Sep. PMID 26013465, Free PMC Article
  2. A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF. Wang LH, et al. J Biol Chem, 1999 May 14. PMID 10318831
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PDZ domain-containing protein GIPC2
Names
SEMCAP-2
semaF cytoplasmic domain associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016867.1 → NP_058563.1  PDZ domain-containing protein GIPC2

    See identical proteins and their annotated locations for NP_058563.1

    Status: PROVISIONAL

    Source sequence(s)
    AF061262
    Consensus CDS
    CCDS17914.1
    UniProtKB/Swiss-Prot
    Q9CVG2, Q9Z2H7
    Related
    ENSMUSP00000037328.9, ENSMUST00000046614.10
    Conserved Domains (1) summary
    cd00992
    Location:116 → 179
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    151799476..151871537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240165.2 → XP_011238467.1  PDZ domain-containing protein GIPC2 isoform X1

    Conserved Domains (1) summary
    cd00992
    Location:24 → 87
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2H7.1 GenPept UniProtKB/Swiss-Prot:Q9Z2H7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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