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CT45A1 cancer/testis antigen family 45 member A1 [ Homo sapiens (human) ]

Gene ID: 541466, updated on 10-Oct-2023

Summary

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Official Symbol
CT45A1provided by HGNC
Official Full Name
cancer/testis antigen family 45 member A1provided by HGNC
Primary source
HGNC:HGNC:33267
See related
Ensembl:ENSG00000268940 MIM:300648; AllianceGenome:HGNC:33267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT45; CT45-1; CT45.1
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 10.8) See more
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Genomic context

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See CT45A1 in Genome Data Viewer
Location:
Xq26.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135708398..135723228)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134058013..134066160)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134847372..134856990)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene sarcoma antigen 3, pseudogene Neighboring gene sarcoma antigen 2, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29985 Neighboring gene MGAT2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29986 Neighboring gene MGAT2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathway. Tang F, et al. Mol Med Rep, 2017 Nov. PMID 28901509, Free PMC Article
  2. DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer. Zhang W, et al. Epigenetics, 2015. PMID 26098711, Free PMC Article
  3. CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis. Shang B, et al. Cell Death Dis, 2014 Jun 5. PMID 24901056, Free PMC Article
  4. Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas. Chen YT, et al. Proc Natl Acad Sci U S A, 2010 Feb 16. PMID 20133697, Free PMC Article
  5. Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer. Chen YT, et al. Int J Cancer, 2009 Jun 15. PMID 19296537

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer.
    Title: YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer.
  2. Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
    Title: Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway.
  3. CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through beta-catenin.
    Title: CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin.
  4. Following CT45A1 silencing, the expressions of Bcl2, survivin, MMP2, MMP9, pERK1/2 and pCREB were downregulated and the expression of Bax was upregulated.
    Title: CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathway.
  5. These data verify CT45 expression and promoter hypomethylation as possible prognostic biomarkers, and suggest CT45 as an immunological or therapeutic target in Epithelial ovarian cancer
    Title: DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer.
  6. CT45A1 functions as a novel proto-oncogene to trigger oncogenesis and metastasis.
    Title: CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis.
  7. Hodgkin lymphoma has the highest CT45 expression among all malignancies tested, in diffuse large B-cell lymphomas it is similar to that seen in epithelial cancers, and not present in low-grade non-Hodgkin B-cell lymphomas.
    Title: Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas.
  8. Over-expression of CT45 is associated with cancer.
    Title: Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
cancer/testis antigen family 45 member A1
Names
cancer/testis antigen 45-1
cancer/testis antigen 45A1
cancer/testis antigen CT45-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017417.3 → NP_001017417.1  cancer/testis antigen family 45 member A1

    See identical proteins and their annotated locations for NP_001017417.1

    Status: VALIDATED

    Source sequence(s)
    AC240442
    Consensus CDS
    CCDS48174.1
    UniProtKB/Swiss-Prot
    B9EIR8, Q5HYN5
    Related
    ENSP00000472303.1, ENST00000594565.6
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    135708398..135723228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531352.2 → XP_011529654.1  cancer/testis antigen family 45 member A1 isoform X1

    See identical proteins and their annotated locations for XP_011529654.1

    UniProtKB/Swiss-Prot
    B9EIR8, Q5HYN5
    Related
    ENSP00000470185.2, ENST00000594117.4
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  2. XM_005278141.5 → XP_005278198.1  cancer/testis antigen family 45 member A1 isoform X1

    See identical proteins and their annotated locations for XP_005278198.1

    UniProtKB/Swiss-Prot
    B9EIR8, Q5HYN5
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  3. XM_047442173.1 → XP_047298129.1  cancer/testis antigen family 45 member A1 isoform X1

    UniProtKB/Swiss-Prot
    B9EIR8, Q5HYN5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    134058013..134066160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327220.1 → XP_054183195.1  cancer/testis antigen family 45 member A1 isoform X1

    UniProtKB/Swiss-Prot
    B9EIR8, Q5HYN5

  2. XM_054327221.1 → XP_054183196.1  cancer/testis antigen family 45 member A1 isoform X1

    UniProtKB/Swiss-Prot
    B9EIR8, Q5HYN5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HYN5.1 GenPept UniProtKB/Swiss-Prot:Q5HYN5

Gene LinkOut

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