Adcy4 adenylate cyclase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcy4provided by RGD
Official Full Name: adenylate cyclase 4provided by RGD
Primary source: RGD:2034
See related: EnsemblRapid:ENSRNOG00000020401 AllianceGenome:RGD:2034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G-protein beta/gamma-subunit complex binding activity and adenylate cyclase activity. Involved in cAMP biosynthetic process and intracellular signal transduction. Located in membrane. Part of protein-containing complex. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 76.9), Lung (RPKM 53.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33236201..33252070, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29266280..29282153, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34453917..34469779, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129786 (e-PCR)
- UniSTS:213078

Adcy4 (e-PCR), detects polymorphism
- UniSTS:141031

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 4

Names: ATP pyrophosphate-lyase 4; adenylate cyclase type IV; adenylyl cyclase 4

NP_062158.2

EC 4.6.1.1

XP_038949538.1

EC 4.6.1.1

XP_038949539.1

EC 4.6.1.1

XP_063130658.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019285.2 → NP_062158.2 adenylate cyclase type 4

See identical proteins and their annotated locations for NP_062158.2

Status: VALIDATED

Source sequence(s)

BC081813

UniProtKB/Swiss-Prot

P26770

UniProtKB/TrEMBL

A6KH53, F7EY48, Q66HK5

Related

ENSRNOP00000027719.4, ENSRNOT00000027719.9

Conserved Domains (4) summary

smart00044
Location:219 → 422

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:861 → 1060

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:479 → 580

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:115 → 246

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

33236201..33252070 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093610.1 → XP_038949538.1 adenylate cyclase type 4 isoform X1

UniProtKB/Swiss-Prot

P26770

Conserved Domains (3) summary

pfam00211
Location:729 → 928

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:1 → 114

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:347 → 448

DUF1053; Domain of Unknown Function (DUF1053)
XM_039093611.1 → XP_038949539.1 adenylate cyclase type 4 isoform X3

Conserved Domains (3) summary

pfam00211
Location:547 → 746

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:165 → 266

DUF1053; Domain of Unknown Function (DUF1053)

cl11967
Location:2 → 116

Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
XM_063274588.1 → XP_063130658.1 adenylate cyclase type 4 isoform X2