Car5a carbonic anhydrase 5A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Car5aprovided by RGD
Official Full Name: carbonic anhydrase 5Aprovided by RGD
Primary source: RGD:2243
See related: EnsemblRapid:ENSRNOG00000019098 AllianceGenome:RGD:2243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ca5; Ca5a
Summary: Enables carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Located in mitochondrion. Orthologous to human CA5A (carbonic anhydrase 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 137.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (66881678..66911486, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (49973092..50002948, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (54731829..54761697, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D19Rat21 (e-PCR)
- UniSTS:119561

AU048492 (e-PCR)
- UniSTS:144942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonic anhydrase 5A, mitochondrial

Names: CA-VA; carbonate dehydratase VA; carbonic anhydrase 5 mitochondrial; carbonic anhydrase Va, mitochondrial

NP_062166.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019293.3 → NP_062166.1 carbonic anhydrase 5A, mitochondrial precursor

See identical proteins and their annotated locations for NP_062166.1

Status: VALIDATED

Source sequence(s)

BC088147

UniProtKB/Swiss-Prot

P43165

UniProtKB/TrEMBL

A6IZQ6

Related

ENSRNOP00000025848.2, ENSRNOT00000025848.6

Conserved Domains (1) summary

cl00012
Location:60 → 295

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...