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Cpa3 carboxypeptidase A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54242, updated on 17-Aug-2024

Summary

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Official Symbol
Cpa3provided by RGD
Official Full Name
carboxypeptidase A3provided by RGD
Primary source
RGD:2390
See related
EnsemblRapid:ENSRNOG00000011181 AllianceGenome:RGD:2390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of angiotensin levels in blood. Predicted to be located in transport vesicle. Predicted to be active in extracellular space. Orthologous to human CPA3 (carboxypeptidase A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 82.7), Thymus (RPKM 45.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104641619..104673253, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102712483..102744219, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (105016798..105047989, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glycogenin 1 Neighboring gene eukaryotic translation initiation factor 4 gamma 1, pseudogene 1 Neighboring gene carboxypeptidase B1 Neighboring gene angiotensin II receptor, type 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning. Xing D, et al. J Surg Res, 2014 Nov. PMID 24953986
  2. Rat mast cell carboxypeptidase: amino acid sequence and evidence of enzyme activity within mast cell granules. Cole KR, et al. Biochemistry, 1991 Jan 22. PMID 1988052
  3. The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain. Kayashima T, et al. Hum Genet, 2003 Mar. PMID 12552318
  4. Human mast cell carboxypeptidase. Purification and characterization. Goldstein SM, et al. J Clin Invest, 1989 May. PMID 2708524, Free PMC Article
  5. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. Lundequist A, et al. J Biol Chem, 2004 Jul 30. PMID 15173164

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that ischemic preconditioning protected against reperfusion injury via the mast cell degranulation-mediated release of MC-CPA.
    Title: Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of angiotensin levels in blood IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of angiotensin levels in blood ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mast cell carboxypeptidase A
Names
R-CPA
RMC-CP
carboxypeptidase A3, mast cell
NP_062173.1
XP_038958908.1
XP_038958909.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019300.1 → NP_062173.1  mast cell carboxypeptidase A precursor

    See identical proteins and their annotated locations for NP_062173.1

    Status: VALIDATED

    Source sequence(s)
    FM101110, U67914
    UniProtKB/Swiss-Prot
    P21961, P97597
    UniProtKB/TrEMBL
    A6IHD2, F1M7S4
    Related
    ENSRNOP00000014970.8, ENSRNOT00000014970.9
    Conserved Domains (2) summary
    pfam02244
    Location:28 → 102
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:114 → 413
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    104641619..104673253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102980.2 → XP_038958908.1  mast cell carboxypeptidase A isoform X1

    UniProtKB/Swiss-Prot
    P21961, P97597
    UniProtKB/TrEMBL
    A0A8I6GL18
    Related
    ENSRNOP00000095188.1, ENSRNOT00000100012.2
    Conserved Domains (2) summary
    pfam02244
    Location:32 → 103
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:114 → 379
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  2. XM_039102981.2 → XP_038958909.1  mast cell carboxypeptidase A isoform X2

    Conserved Domains (2) summary
    pfam02244
    Location:32 → 103
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:114 → 327
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21961.2 GenPept UniProtKB/Swiss-Prot:P21961

Gene LinkOut

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