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Dgkb diacylglycerol kinase, beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 54248, updated on 10-Oct-2024

Summary

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Official Symbol
Dgkbprovided by RGD
Official Full Name
diacylglycerol kinase, betaprovided by RGD
Primary source
RGD:2488
See related
EnsemblRapid:ENSRNOG00000030771 AllianceGenome:RGD:2488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dagk; DGK-beta
Summary
Enables diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and phosphatidic acid biosynthetic process. Located in membrane. Orthologous to human DGKB (diacylglycerol kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 223.5), Heart (RPKM 36.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dgkb in Genome Data Viewer
Location:
6q21
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (60368101..61124420)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (54640948..55397210)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (57516351..58277385)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351363 Neighboring gene ribosomal protein S25 like 2 Neighboring gene actin, gamma 1, pseudogene 1 Neighboring gene thyroid hormone receptor-associated protein 3 pseudogene Neighboring gene uncharacterized LOC134479368 Neighboring gene phosphatidylethanolamine binding protein 1, pseudogene 2 Neighboring gene ETS variant transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons. Hozumi Y, et al. BMC Neurosci, 2009 Aug 19. PMID 19691842, Free PMC Article
  2. Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum. Hozumi Y, et al. Eur J Neurosci, 2008 Dec. PMID 19087171
  3. Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy. Yahagi H, et al. Biochem Biophys Res Commun, 2005 Jun 24. PMID 15896305
  4. Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function. Shirai Y, et al. PLoS One, 2010 Jul 15. PMID 20657643, Free PMC Article
  5. Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain. Adachi N, et al. Brain Res Mol Brain Res, 2005 Oct 3. PMID 16019106

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that dgkb distribuate in rat cerebellum.
    Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
  2. The DGKbeta localize in the outer plexiform layer, within which photoreceptor cells make contact with bipolar and horizontal cells.
    Title: Distinct expression and localization of diacylglycerol kinase isozymes in rat retina.
  3. functional roles of DGK in the pituitary intermediate lobe
    Title: Signaling cascade of diacylglycerol kinase β in the pituitary intermediate lobe: dopamine D2 receptor/phospholipase Cβ4/diacylglycerol kinase β/protein kinase Cα.
  4. In the hippocampus, DGKbeta is expressed in both projection neurons and interneurons and is accumulated at the perisynapse of dendritic spines in asymmetrical synapses. It may be involved in dendrite outgrowth and spinogenesis.
    Title: Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons.
  5. Data suggest that abundant diacylglycerol kinase beta is present perisynaptically in medium spiny neurons so that it can effectively produce phosphatidic acid upon activation of Gq-coupled receptors and modulate striatal output neurons.
    Title: Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum.
  6. These results suggest that DGKepsilon and DGKzeta play distinct roles in the development of pressure overloaded cardiac hypertrophy and that the two isozymes are differentially regulated.
    Title: Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy.
  7. In most brain regions, DGKbeta showed sustained expression throughout the postnatal developmental periods. And In the hippocampal pyramidal cell, DGKbeta localized along the membrane structure.
    Title: Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
diacylglycerol kinase beta
Names
90 kDa diacylglycerol kinase
DAG kinase beta
Diacylglycerol kinase 90kDa
diacylglycerol kinase beta, 90kDa
diglyceride kinase beta
NP_062177.2
XP_008762871.2
XP_017449817.1
XP_017449818.1
XP_017449819.1
XP_063118430.1
XP_063118431.1
XP_063118432.1
XP_063118433.1
XP_063118434.1
XP_063118435.1
XP_063118436.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019304.2 → NP_062177.2  diacylglycerol kinase beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P49621
    UniProtKB/TrEMBL
    A6HBB8, F1LP01
    Related
    ENSRNOP00000058842.2, ENSRNOT00000063874.5
    Conserved Domains (6) summary
    smart00045
    Location:580 → 760
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:438 → 559
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:6 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20845
    Location:237 → 302
    C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
    cd20891
    Location:307 → 365
    C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    60368101..61124420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262362.1 → XP_063118432.1  diacylglycerol kinase beta isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZWT2

  2. XM_017594328.3 → XP_017449817.1  diacylglycerol kinase beta isoform X1

    UniProtKB/Swiss-Prot
    P49621
    Conserved Domains (6) summary
    smart00045
    Location:581 → 761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439 → 560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:6 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20845
    Location:237 → 302
    C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
    cd20891
    Location:307 → 365
    C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

  3. XM_063262364.1 → XP_063118434.1  diacylglycerol kinase beta isoform X5

  4. XM_017594330.3 → XP_017449819.1  diacylglycerol kinase beta isoform X3

    UniProtKB/Swiss-Prot
    P49621

  5. XM_063262366.1 → XP_063118436.1  diacylglycerol kinase beta isoform X6

  6. XM_063262360.1 → XP_063118430.1  diacylglycerol kinase beta isoform X2

    UniProtKB/TrEMBL
    A6HBB8, F1LP01

  7. XM_017594329.3 → XP_017449818.1  diacylglycerol kinase beta isoform X3

    UniProtKB/Swiss-Prot
    P49621
    Related
    ENSRNOP00000082015.2, ENSRNOT00000111621.2

  8. XM_008764649.4 → XP_008762871.2  diacylglycerol kinase beta isoform X1

    UniProtKB/Swiss-Prot
    P49621
    Conserved Domains (6) summary
    smart00045
    Location:581 → 761
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:439 → 560
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:152 → 221
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:6 → 148
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20845
    Location:237 → 302
    C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
    cd20891
    Location:307 → 365
    C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

  9. XM_063262363.1 → XP_063118433.1  diacylglycerol kinase beta isoform X5

  10. XM_063262361.1 → XP_063118431.1  diacylglycerol kinase beta isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZWT2
    Related
    ENSRNOP00000106123.1, ENSRNOT00000134799.1

  11. XM_063262365.1 → XP_063118435.1  diacylglycerol kinase beta isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49621.1 GenPept UniProtKB/Swiss-Prot:P49621

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