Tpsab1 tryptase alpha/beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpsab1provided by RGD
Official Full Name: tryptase alpha/beta 1provided by RGD
Primary source: RGD:3066
See related: EnsemblRapid:ENSRNOG00000024181 AllianceGenome:RGD:3066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mcpt7; TPSB1; rMCP-7
Summary: Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in extracellular matrix disassembly and proteolysis. Predicted to be located in mast cell granule. Predicted to be active in extracellular space. Orthologous to human TPSAB1 (tryptase alpha/beta 1) and TPSD1 (tryptase delta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 9.4), Thymus (RPKM 9.3) and 7 other tissues See more
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Genomic context

Location:: 10q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14864887..14867302, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14360396..14362811, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14701253..14703668, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tryptase can stimulate myoblast proliferation and this effect is part of a signaling cascade dependent on PAR-2 activation and on the downstream activation of COX-2.
Title: Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2.

Submit: New GeneRIF Correction

General gene information

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Markers

Tpsb2 (e-PCR), detects polymorphism
- UniSTS:536700

BF413054 (e-PCR)
- UniSTS:248494

Mcpt7 (e-PCR), detects polymorphism
- UniSTS:143845

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mast cell granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tryptase

Names: MMCP-7; mast cell protease 7; tryptase beta 1; tryptase, skin

NP_062195.2

EC 3.4.21.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019322.2 → NP_062195.2 tryptase precursor

See identical proteins and their annotated locations for NP_062195.2

Status: VALIDATED

Source sequence(s)

BC061983, U67910

UniProtKB/TrEMBL

A6HD21, G3V8E5, Q6P6W8

Related

ENSRNOP00000025095.1, ENSRNOT00000024767.4

Conserved Domains (2) summary

smart00020
Location:66 → 302

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:66 → 302

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...