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PCOTH prostate and testis expressed opposite C1QTNF9B and MIPEP [ Homo sapiens (human) ]

Gene ID: 542767, updated on 2-Nov-2024

Summary

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Official Symbol
PCOTHprovided by HGNC
Official Full Name
prostate and testis expressed opposite C1QTNF9B and MIPEPprovided by HGNC
Primary source
HGNC:HGNC:39839
See related
Ensembl:ENSG00000205861 MIM:617122; AllianceGenome:HGNC:39839
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1QTNF9B-AS1
Summary
Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 11.5), prostate (RPKM 9.5) and 14 other tissues See more
Orthologs
all
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Genomic context

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See PCOTH in Genome Data Viewer
Location:
13q12.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (23888868..23892103)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (23095303..23098541)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (24463007..24466242)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7462 Neighboring gene mitochondrial intermediate peptidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7464 Neighboring gene MT-CO3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7467 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24386207-24386732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:24463319-24463819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24477599-24478098 Neighboring gene C1q and TNF related 9B Neighboring gene ankyrin repeat domain 20 family member A19, pseudogene Neighboring gene uncharacterized LOC105370115

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. Anazawa Y, et al. Cancer Res, 2005 Jun 1. PMID 15930275
  2. Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population. Shi Y, et al. Am J Hum Genet, 2011 Jun 10. PMID 21640322, Free PMC Article
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCOTH is involved in growth and survival of prostate cancer cells thorough, in parts, the TAF-Ibeta pathway.
    Title: PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • C1QTNF9B antisense RNA 1
  • C1QTNF9B antisense gene protein 1
  • Pro-X-Gly collagen triple helix like repeat containing
  • prostate collagen triple helix protein

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_172510.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445985
    Related
    ENST00000382133.10

  2. NR_172511.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445985
    Related
    ENST00000849009.1

  3. NR_172512.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445985

  4. NR_172513.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445985

  5. NR_172514.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445985

  6. NR_172515.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445985
    Related
    ENST00000849011.1

  7. NR_172516.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL445985

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    23888868..23892103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    23095303..23098541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58A44.2 GenPept UniProtKB/Swiss-Prot:Q58A44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials