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Cntn3 contactin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54279, updated on 17-Aug-2024

Summary

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Official Symbol
Cntn3provided by RGD
Official Full Name
contactin 3provided by RGD
Primary source
RGD:3253
See related
EnsemblRapid:ENSRNOG00000006144 AllianceGenome:RGD:3253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pang; BIG-1
Summary
Involved in nervous system development. Predicted to be active in neuron projection. Orthologous to human CNTN3 (contactin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 49.4), Uterus (RPKM 6.8) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Cntn3 in Genome Data Viewer
Location:
4q34-q41
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (136397575..136770765, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (134841268..135214460, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (134783671..135159309, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B, pseudogene 2 Neighboring gene ribosomal protein L13, pseudogene 14 Neighboring gene U2 spliceosomal RNA Neighboring gene small Cajal body-specific RNA 16 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BIG-1: a new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity. Yoshihara Y, et al. Neuron, 1994 Aug. PMID 8060619
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
contactin-3
Names
Plasmacytoma-associated neuronal glycoprotein (neural cell adhesion molecule BIG-1)
brain-derived immunoglobulin superfamily protein 1
contactin 3 (plasmacytoma associated)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019329.2 → NP_062202.1  contactin-3 precursor

    See identical proteins and their annotated locations for NP_062202.1

    Status: PROVISIONAL

    Source sequence(s)
    U11031
    UniProtKB/Swiss-Prot
    Q62682
    UniProtKB/TrEMBL
    A0A8I6A9N6
    Related
    ENSRNOP00000008221.6, ENSRNOT00000008221.8
    Conserved Domains (4) summary
    smart00410
    Location:234 → 313
    IG_like; Immunoglobulin like
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:318 → 403
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:227 → 315
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    136397575..136770765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236968.5 → XP_006237030.1  contactin-3 isoform X1

    See identical proteins and their annotated locations for XP_006237030.1

    UniProtKB/Swiss-Prot
    Q62682
    UniProtKB/TrEMBL
    A0A8I6A9N6
    Conserved Domains (4) summary
    smart00410
    Location:234 → 313
    IG_like; Immunoglobulin like
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:318 → 403
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:227 → 315
    Ig; Immunoglobulin domain

  2. XM_039108281.2 → XP_038964209.1  contactin-3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A9N6
    Related
    ENSRNOP00000099826.1, ENSRNOT00000123239.1
    Conserved Domains (3) summary
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:498 → 504
    Ig; Ig strand A [structural motif]
    cl11960
    Location:498 → 598
    Ig; Immunoglobulin domain

  3. XM_063286624.1 → XP_063142694.1  contactin-3 isoform X4

  4. XM_039108284.2 → XP_038964212.1  contactin-3 isoform X4

    Conserved Domains (3) summary
    cd00063
    Location:184 → 281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:84 → 90
    Ig; Ig strand A [structural motif]
    cl11960
    Location:84 → 184
    Ig; Immunoglobulin domain

  5. XM_039108283.2 → XP_038964211.1  contactin-3 isoform X4

    Conserved Domains (3) summary
    cd00063
    Location:184 → 281
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:84 → 90
    Ig; Ig strand A [structural motif]
    cl11960
    Location:84 → 184
    Ig; Immunoglobulin domain

  6. XM_039108282.2 → XP_038964210.1  contactin-3 isoform X3

    UniProtKB/TrEMBL
    A6IBJ1
    Conserved Domains (3) summary
    cd00063
    Location:598 → 691
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:498 → 504
    Ig; Ig strand A [structural motif]
    cl11960
    Location:498 → 598
    Ig; Immunoglobulin domain

  7. XM_039108285.2 → XP_038964213.1  contactin-3 isoform X5

    UniProtKB/TrEMBL
    A6IBJ1
    Conserved Domains (2) summary
    cd00096
    Location:227 → 232
    Ig; Ig strand A [structural motif]
    cl11960
    Location:227 → 315
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62682.1 GenPept UniProtKB/Swiss-Prot:Q62682

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