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Rgs5 regulator of G-protein signaling 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54294, updated on 5-Mar-2024

Summary

Official Symbol
Rgs5provided by RGD
Official Full Name
regulator of G-protein signaling 5provided by RGD
Primary source
RGD:3568
See related
Ensembl:ENSRNOG00000002730 AllianceGenome:RGD:3568
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in negative regulation of vascular associated smooth muscle cell proliferation and signal transduction. Predicted to be located in cytoplasm and membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human RGS5 (regulator of G protein signaling 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1671.0), Muscle (RPKM 867.1) and 7 other tissues See more
Orthologs
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Genomic context

See Rgs5 in Genome Data Viewer
Location:
13q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (84381077..84417875)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (81848254..81885053)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (87966820..88002831)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692065 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 7 Neighboring gene NUF2 component of NDC80 kinetochore complex Neighboring gene regulator of G-protein signaling 4 Neighboring gene uncharacterized LOC134481531 Neighboring gene coiled-coil domain containing 190

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019341.1NP_062214.1  regulator of G-protein signaling 5

    See identical proteins and their annotated locations for NP_062214.1

    Status: PROVISIONAL

    Source sequence(s)
    AF241259
    UniProtKB/Swiss-Prot
    P49800, Q9JKD7
    UniProtKB/TrEMBL
    A0A0G2JVF3, A5YN34
    Related
    ENSRNOP00000069463.2, ENSRNOT00000079593.2
    Conserved Domains (1) summary
    cd08717
    Location:65178
    RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    84381077..84417875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)