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Slk STE20-like kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 54308, updated on 2-Nov-2024

Summary

Official Symbol
Slkprovided by RGD
Official Full Name
STE20-like kinaseprovided by RGD
Primary source
RGD:3780
See related
EnsemblRapid:ENSRNOG00000011339 AllianceGenome:RGD:3780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SK2; Stk2
Summary
Enables histone kinase activity. Involved in cellular response to cytokine stimulus; positive regulation of apoptotic process; and protein autophosphorylation. Predicted to be located in cell leading edge and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 242.5), Heart (RPKM 185.9) and 9 other tissues See more
Orthologs
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Genomic context

See Slk in Genome Data Viewer
Location:
1q54
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256415013..256470942)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246473712..246529643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267359761..267415735)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100049 Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene collagen type XVII alpha 1 chain Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell leading edge IEA
Inferred from Electronic Annotation
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
STE20-like serine/threonine-protein kinase
Names
STE20-related kinase
STE20-related serine/threonine-protein kinase
serine/threonine kinase 2
NP_062222.2
XP_006231620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019349.2NP_062222.2  STE20-like serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    AB003357, AI136919, CK227996
    UniProtKB/TrEMBL
    A6JHQ9, G3V7I8
    Related
    ENSRNOP00000015496.4, ENSRNOT00000015495.7
    Conserved Domains (3) summary
    smart00220
    Location:34292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:9881128
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    256415013..256470942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231558.5XP_006231620.1  STE20-like serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006231620.1

    UniProtKB/TrEMBL
    A0A8I6A6A2, A6JHQ8, A6JHQ9, G3V7I8
    Related
    ENSRNOP00000087678.1, ENSRNOT00000119890.2
    Conserved Domains (3) summary
    smart00220
    Location:34292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:10191159
    PKK; Polo kinase kinase