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Cpq carboxypeptidase Q [ Mus musculus (house mouse) ]

Gene ID: 54381, updated on 2-Nov-2024

Summary

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Official Symbol
Cpqprovided by MGI
Official Full Name
carboxypeptidase Qprovided by MGI
Primary source
MGI:MGI:1889205
See related
Ensembl:ENSMUSG00000039007 AllianceGenome:MGI:1889205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hls2; Pgcp; Lal-1; 1190003P12Rik; 2610034C17Rik
Summary
Predicted to enable metallodipeptidase activity and protein homodimerization activity. Predicted to be involved in several processes, including peptide catabolic process; thyroid hormone generation; and tissue regeneration. Located in lysosome. Is expressed in genitourinary system. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 26.1), subcutaneous fat pad adult (RPKM 15.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Cpq in Genome Data Viewer
Location:
15 B3.1; 15 13.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (33083275..33594698)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (33083129..33594552)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53871 Neighboring gene syndecan 2 Neighboring gene STARR-seq mESC enhancer starr_38300 Neighboring gene STARR-seq mESC enhancer starr_38301 Neighboring gene predicted gene, 32764 Neighboring gene STARR-seq mESC enhancer starr_38302 Neighboring gene STARR-seq mESC enhancer starr_38303 Neighboring gene ribosomal protein L7-like 1 pseudogene Neighboring gene RIKEN cDNA 4930592A05 gene Neighboring gene STARR-seq mESC enhancer starr_38305 Neighboring gene predicted gene, 53872 Neighboring gene testis-specific protein, Y-encoded-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation. Della Fazia MA, et al. J Cell Sci, 2005 Jul 15. PMID 16014383
  2. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article
  3. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallodipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallodipeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone generation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tissue regeneration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
carboxypeptidase Q
Names
hematopoietic lineage switch 2
plasma glutamate carboxypeptidase
NP_061225.2
NP_788262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018755.2 → NP_061225.2  carboxypeptidase Q precursor

    See identical proteins and their annotated locations for NP_061225.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK152145, BB472698, CK624628
    Consensus CDS
    CCDS27414.1
    UniProtKB/Swiss-Prot
    O70216, Q3U8N9, Q9WVJ3
    Related
    ENSMUSP00000154400.2, ENSMUST00000228916.2
    Conserved Domains (2) summary
    cd03883
    Location:45 → 447
    M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
    cd04815
    Location:128 → 254
    PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

  2. NM_176073.4 → NP_788262.1  carboxypeptidase Q precursor

    See identical proteins and their annotated locations for NP_788262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK135096, BB472698, CK624628
    Consensus CDS
    CCDS27414.1
    UniProtKB/Swiss-Prot
    O70216, Q3U8N9, Q9WVJ3
    Related
    ENSMUSP00000039046.10, ENSMUST00000042167.10
    Conserved Domains (2) summary
    cd03883
    Location:45 → 447
    M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
    cd04815
    Location:128 → 254
    PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    33083275..33594698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVJ3.1 GenPept UniProtKB/Swiss-Prot:Q9WVJ3

Gene LinkOut

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