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Bet1l Bet1 golgi vesicular membrane trafficking protein like [ Mus musculus (house mouse) ]

Gene ID: 54399, updated on 28-Oct-2024

Summary

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Official Symbol
Bet1lprovided by MGI
Official Full Name
Bet1 golgi vesicular membrane trafficking protein likeprovided by MGI
Primary source
MGI:MGI:1913128
See related
Ensembl:ENSMUSG00000025484 AllianceGenome:MGI:1913128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gs15; 2610021K23Rik
Summary
Enables SNAP receptor activity. Predicted to be involved in regulation of retrograde vesicle-mediated transport, Golgi to ER and retrograde transport, endosome to Golgi. Located in Golgi membrane and Golgi stack. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human BET1L (Bet1 golgi vesicular membrane trafficking protein like). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 17.1), limb E14.5 (RPKM 16.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bet1l in Genome Data Viewer
Location:
7 F4; 7 86.05 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140433297..140437306, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140853384..140857156, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330022C24 gene Neighboring gene secretoglobin, family 1C, member 1 Neighboring gene ciliary microtubule associated protein 1A Neighboring gene STARR-positive B cell enhancer ABC_E1748 Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene sirtuin 3 Neighboring gene STARR-positive B cell enhancer ABC_E9304 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain. Nagy G, et al. Mol Biol Cell, 2005 Dec. PMID 16195346, Free PMC Article
  2. GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1. Xu Y, et al. J Biol Chem, 1997 Aug 8. PMID 9242691
  3. Myb proteins regulate the expression of diverse target genes. Lang G, et al. Oncogene, 2005 Feb 17. PMID 15608679
  4. The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. Zeng Q, et al. J Biol Chem, 2003 Jun 20. PMID 12682051
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two amino acidubstitutions do not regulate secretion by affecting the property of SNARE complex itself.
    Title: Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BET1-like protein
Names
GOS-15
blocked early in transport 1 homolog-like
golgi SNARE with a size of 15 kDa
golgi SNARE, 15 kD
soluble N-ethylmaleimide-sensitive factor attachment protein (SNARE) 15
vesicle transport protein GOS15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018742.5 → NP_061212.3  BET1-like protein

    See identical proteins and their annotated locations for NP_061212.3

    Status: VALIDATED

    Source sequence(s)
    AK011508, AK161239, BY292666
    Consensus CDS
    CCDS21987.1
    UniProtKB/Swiss-Prot
    O35153, Q9D0E4
    UniProtKB/TrEMBL
    A0A1B0GS34
    Related
    ENSMUSP00000026557.9, ENSMUST00000026557.10
    Conserved Domains (1) summary
    cd15853
    Location:18 → 76
    SNARE_Bet1; SNARE motif of Bet1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140433297..140437306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242798.2 → XP_030098658.1  BET1-like protein isoform X1

    UniProtKB/Swiss-Prot
    O35153, Q9D0E4
    UniProtKB/TrEMBL
    A0A1B0GS34
    Conserved Domains (1) summary
    cd15853
    Location:18 → 76
    SNARE_Bet1; SNARE motif of Bet1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35153.1 GenPept UniProtKB/Swiss-Prot:O35153

Gene LinkOut

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