PON3 paraoxonase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PON3provided by HGNC
Official Full Name: paraoxonase 3provided by HGNC
Primary source: HGNC:HGNC:9206
See related: Ensembl:ENSG00000105852 MIM:602720; AllianceGenome:HGNC:9206
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver (RPKM 130.3) and ovary (RPKM 7.4) See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (95359872..95396375, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (96596019..96632523, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (94989184..95025687, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered HDL proteome predicts incident CVD in chronic kidney disease patients.
Title: Altered HDL proteome predicts incident CVD in chronic kidney disease patients.
Serum paraoxonase 1 and 3 activities in benign and malignant diseases of the prostate and changes in levels following robotic-assisted laparoscopic radical prostatectomy
Title: Serum paraoxonase 1 and 3 activities in benign and malignant diseases of the prostate and changes in levels following robotic-assisted laparoscopic radical prostatectomy.
Micro- and macrovascular cardiac allograft vasculopathy in relation to 91 cardiovascular biomarkers in heart transplant recipients-An exploratory study.
Title: Micro- and macrovascular cardiac allograft vasculopathy in relation to 91 cardiovascular biomarkers in heart transplant recipients-An exploratory study.
Paraoxonase 3 gene polymorphisms are associated with occupational noise-induced deafness: A matched case-control study from China.
Title: Paraoxonase 3 gene polymorphisms are associated with occupational noise-induced deafness: A matched case-control study from China.
Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease.
Title: Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease.
PON1 and PON3 promoter methylation levels in peripheral blood were closely related. PON1 and PON3 methylation were associated with the risk of cerebral infarction in men.
Title: PON1 Hypermethylation and PON3 Hypomethylation are Associated with Risk of Cerebral Infarction.
No significant differences were observed between PON2 and PON3 gene expression in psoriatic lesional and non lesional skin compared with healthy controls
Title: Paraoxonases and psoriasis: negative imbalance of antioxidant endogenous mechanisms.
In donor retina from patients with diabetes, all three PON1, PON2 and PON3 were expressed, and there was a significant increase in PON3 expression compared to control. This might be the reason for the increased thiolactonase activity observed in diabetic retina compared to control
Title: Ocular distribution of antioxidant enzyme paraoxonase & its alteration in cataractous lens & diabetic retina.
PON3 suppressed cell proliferation in vivo and in vitro, which was attributed to its cell-cycle arrest effect.
Title: Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma.
PON3 protein can be detected in plasma and resides in the high-density lipoprotein fraction and protects against Oxidative stress by hydrolyzing certain oxidized lipids in lipoproteins, macrophages and Atherosclerotic lesions.
Title: [Paraoxonase: The Universal Factor of Antioxidant Defense in Human Body].

Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	The interaction of HIV-1 CA with human cellular paraoxonase 3 protein (PON3) is identified by yeast two-hybrid screen	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables acyl-L-homoserine-lactone lactonohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables aryldialkylphosphatase activity	IEA Inferred from Electronic Annotation more info
enables arylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables arylesterase activity	NAS Non-traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carboxylic acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
involved_in lactone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to drug	IDA Inferred from Direct Assay more info	PubMed
involved_in renal sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serum paraoxonase/lactonase 3

Names: arylesterase 3; paraoxanase-3

NP_000931.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.