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Uqcc6 ubiquinol-cytochrome c reductase complex assembly factor 6 [ Mus musculus (house mouse) ]

Gene ID: 544717, updated on 2-Nov-2024

Summary

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Official Symbol
Uqcc6provided by MGI
Official Full Name
ubiquinol-cytochrome c reductase complex assembly factor 6provided by MGI
Primary source
MGI:MGI:3698433
See related
Ensembl:ENSMUSG00000063320 AllianceGenome:MGI:3698433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brawnin; 1190007I07Rik
Summary
Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in cerebral cortex. Orthologous to human UQCC6 (ubiquinol-cytochrome c reductase complex assembly factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 22.0), duodenum adult (RPKM 15.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uqcc6 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82455685..82459062, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82619851..82623228, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27364 Neighboring gene required for meiotic nuclear division 5 homolog A pseudogene Neighboring gene adaptor-related protein complex 3, mu 1 subunit, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10632 Neighboring gene STARR-positive B cell enhancer ABC_E6890 Neighboring gene STARR-positive B cell enhancer ABC_E578 Neighboring gene STARR-seq mESC enhancer starr_27366 Neighboring gene thymine DNA glycosylase Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:82129373-82129482 Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8353 Neighboring gene STARR-seq mESC enhancer starr_27367 Neighboring gene STARR-seq mESC enhancer starr_27368 Neighboring gene host cell factor C2 Neighboring gene STARR-positive B cell enhancer ABC_E6891 Neighboring gene nuclear transcription factor-Y beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions. Lanfranchi M, et al. Nat Commun, 2024 Mar 21. PMID 38514619, Free PMC Article
  2. Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. Liang C, et al. Cell Rep, 2022 Aug 16. PMID 35977508
  3. Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly. Zhang S, et al. Nat Commun, 2020 Mar 11. PMID 32161263, Free PMC Article
  4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquinol-cytochrome c reductase complex assembly factor 6
Names
protein BRAWNIN
uncharacterized protein C12orf73 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135567.1 → NP_001129039.1  ubiquinol-cytochrome c reductase complex assembly factor 6

    See identical proteins and their annotated locations for NP_001129039.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC152980, AK004515
    Consensus CDS
    CCDS48653.1
    UniProtKB/Swiss-Prot
    Q8BTC1
    Related
    ENSMUSP00000078593.5, ENSMUST00000079648.12
    Conserved Domains (1) summary
    pfam14990
    Location:2 → 44
    DUF4516; Domain of unknown function (DUF4516)

  2. NM_001135568.1 → NP_001129040.1  ubiquinol-cytochrome c reductase complex assembly factor 6

    See identical proteins and their annotated locations for NP_001129040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC152980, DV649038
    Consensus CDS
    CCDS48653.1
    UniProtKB/Swiss-Prot
    Q8BTC1
    Related
    ENSMUSP00000139234.2, ENSMUST00000183363.2
    Conserved Domains (1) summary
    pfam14990
    Location:2 → 44
    DUF4516; Domain of unknown function (DUF4516)

  3. NM_001135569.1 → NP_001129041.1  ubiquinol-cytochrome c reductase complex assembly factor 6

    See identical proteins and their annotated locations for NP_001129041.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' UTR, compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC152980
    Consensus CDS
    CCDS48653.1
    UniProtKB/Swiss-Prot
    Q8BTC1
    Related
    ENSMUSP00000139244.2, ENSMUST00000185168.8
    Conserved Domains (1) summary
    pfam14990
    Location:2 → 44
    DUF4516; Domain of unknown function (DUF4516)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    82455685..82459062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTC1.1 GenPept UniProtKB/Swiss-Prot:Q8BTC1

Gene LinkOut

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