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Fam186b family with sequence similarity 186, member B [ Mus musculus (house mouse) ]

Gene ID: 545136, updated on 2-Nov-2024

Summary

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Official Symbol
Fam186bprovided by MGI
Official Full Name
family with sequence similarity 186, member Bprovided by MGI
Primary source
MGI:MGI:3647604
See related
Ensembl:ENSMUSG00000078907 AllianceGenome:MGI:3647604
Gene type
protein coding
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG545136
Summary
Predicted to be part of protein-containing complex. Is expressed in large intestine; metanephros; ovary; and testis. Orthologous to human FAM186B (family with sequence similarity 186 member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 23.2) and adrenal adult (RPKM 0.5) See more
Orthologs
human all
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Genomic context

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See Fam186b in Genome Data Viewer
Location:
15 F1; 15 56.11 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99168899..99199656, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99271018..99301775, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 3 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99082061-99082244 Neighboring gene STARR-positive B cell enhancer ABC_E1486 Neighboring gene STARR-positive B cell enhancer ABC_E7417 Neighboring gene microspherule protein 1 Neighboring gene predicted gene, 25999 Neighboring gene pre-mRNA processing factor 40B Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99163430-99163646 Neighboring gene formin-like 3 Neighboring gene STARR-seq mESC enhancer starr_39705 Neighboring gene STARR-positive B cell enhancer ABC_E9923 Neighboring gene STARR-positive B cell enhancer ABC_E3156 Neighboring gene predicted gene, 22951 Neighboring gene transmembrane BAX inhibitor motif containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM186B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081254.1 → NP_001074723.1  protein FAM186B

    See identical proteins and their annotated locations for NP_001074723.1

    Status: INFERRED

    Source sequence(s)
    AC161198
    Consensus CDS
    CCDS37200.1
    UniProtKB/TrEMBL
    D3Z420
    Related
    ENSMUSP00000104728.2, ENSMUST00000109100.2
    Conserved Domains (2) summary
    PRK13729
    Location:236 → 352
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    pfam09756
    Location:476 → 539
    DDRGK; DDRGK domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99168899..99199656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521173.5 → XP_006521236.1  protein FAM186B isoform X2

    Conserved Domains (2) summary
    PRK13729
    Location:104 → 220
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    pfam03999
    Location:346 → 494
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  2. XM_017316703.3 → XP_017172192.1  protein FAM186B isoform X2

    Conserved Domains (2) summary
    PRK13729
    Location:104 → 220
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    pfam03999
    Location:346 → 494
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  3. XM_006521172.5 → XP_006521235.1  protein FAM186B isoform X1

    Conserved Domains (2) summary
    PRK13729
    Location:236 → 352
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    pfam03999
    Location:478 → 626
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
Nucleotide Protein Strain
Heading Accession and Version

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