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Mterf1a mitochondrial transcription termination factor 1a [ Mus musculus (house mouse) ]

Gene ID: 545725, updated on 2-Nov-2024

Summary

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Official Symbol
Mterf1aprovided by MGI
Official Full Name
mitochondrial transcription termination factor 1aprovided by MGI
Primary source
MGI:MGI:1918240
See related
Ensembl:ENSMUSG00000040429 AllianceGenome:MGI:1918240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mterf; Mterf1; mTERF1b; 4931431L11Rik; 9230106K09Rik
Summary
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in DNA geometric change and termination of mitochondrial transcription. Located in mitochondrion. Orthologous to human MTERF1 (mitochondrial transcription termination factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 1.7), CNS E11.5 (RPKM 1.6) and 23 other tissues See more
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Genomic context

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See Mterf1a in Genome Data Viewer
Location:
5 A1; 5 2.26 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (3914576..3943933, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (3864565..3893933, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and IBR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4742 Neighboring gene STARR-seq mESC enhancer starr_12318 Neighboring gene KRIT1, ankyrin repeat containing Neighboring gene STARR-seq mESC enhancer starr_12319 Neighboring gene STARR-seq mESC enhancer starr_12320 Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1296 Neighboring gene Rps4x retrotransposed pseudogene Neighboring gene STARR-seq mESC enhancer starr_12321 Neighboring gene predicted gene, 51438 Neighboring gene A kinase anchor protein 9 Neighboring gene Wdr46 retrotransposed pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Terzioglu M, et al. Cell Metab, 2013 Apr 2. PMID 23562081
  2. Cloning and characterization of mouse mTERF encoding a mitochondrial transcriptional termination factor. Li X, et al. Biochem Biophys Res Commun, 2005 Jan 14. PMID 15582606
  3. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. McNally RS, et al. J Biol Chem, 2011 Feb 11. PMID 21097510, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MTERF1 does not regulate heavy-strand transcription, but rather acts to block transcription on the opposite strand of mtDNA to prevent transcription interference at the light-strand promoter.
    Title: MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA geometric change ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA geometric change ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA-templated transcription termination ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA-templated transcription termination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in termination of mitochondrial transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription termination factor 1a, mitochondrial
Names
mitochondrial transcription termination factor 1
mitochondrial transcription termination factor 1b
transcription termination factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013023.2 → NP_001013041.2  transcription termination factor 1a, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001013041.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027653, AK049308
    Consensus CDS
    CCDS39003.1
    UniProtKB/Swiss-Prot
    Q63ZX5, Q8C7T1, Q8CHZ9
    Related
    ENSMUSP00000046017.5, ENSMUST00000044746.5
    Conserved Domains (1) summary
    pfam02536
    Location:58 → 371
    mTERF; mTERF

  2. NM_172135.2 → NP_742147.1  transcription termination factor 1a, mitochondrial precursor

    See identical proteins and their annotated locations for NP_742147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027653, CJ061450
    Consensus CDS
    CCDS39003.1
    UniProtKB/Swiss-Prot
    Q63ZX5, Q8C7T1, Q8CHZ9
    Conserved Domains (1) summary
    pfam02536
    Location:58 → 371
    mTERF; mTERF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    3914576..3943933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320999.3 → XP_017176488.1  transcription termination factor 1a, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam02536
    Location:60 → 373
    mTERF

  2. XM_017321000.2 → XP_017176489.1  transcription termination factor 1a, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam02536
    Location:60 → 373
    mTERF

RNA

  1. XR_003955677.2 RNA Sequence

  2. XR_004942541.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHZ9.1 GenPept UniProtKB/Swiss-Prot:Q8CHZ9

Gene LinkOut

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