Sfrp5 secreted frizzled-related sequence protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sfrp5provided by MGI
Official Full Name: secreted frizzled-related sequence protein 5provided by MGI
Primary source: MGI:MGI:1860298
See related: Ensembl:ENSMUSG00000018822 AllianceGenome:MGI:1860298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SARP3
Summary: Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including convergent extension involved in axis elongation; negative regulation of JUN kinase activity; and post-anal tail morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; ear; early conceptus; nervous system; and reproductive system. Orthologous to human SFRP5 (secreted frizzled related protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in genital fat pad adult (RPKM 20.6), subcutaneous fat pad adult (RPKM 18.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 35.93 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (42186410..42190691, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (42197971..42202252, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5.
Title: Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5.
Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway.
Title: Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway.
Hyperactivated Wnt-beta-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2.
Title: Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2.
Central Sfrp5 signaling activates a previously unappreciated InsR-Akt-PI3k-KATP channel pathway in the hypothalamus and brain-hepatic vagus neurocircuitry to decrease hepatic glucose production and VLDL-triglyceride secretion.
Title: Central Sfrp5 regulates hepatic glucose flux and VLDL-triglyceride secretion.
Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle.
Title: Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle.
SFRP5 be a target gene of PPARgamma.
Title: SFRP5 is a target gene transcriptionally regulated by PPARγ in 3T3-L1 adipocytes.
The balance of factors controlling fat deposition can be evaluated in part by the differential expression profiles of Mest and Sfrp5 genes with functions linked to fat deposition as long as there is an active accumulation of fat mass.
Title: Mest and Sfrp5 are biomarkers for healthy adipose tissue.
the expression of Mest and Sfrp5 were tightly associated across the 5 mouse strains with the highest and lowest expression occurring in DBA/2J and C57BL/6J (B6) respectively suggesting a common mechanism for their regulation.
Title: Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet.
MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 and Sfrp5.
Title: MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5.
although high sFRP5 expression inhibits B-lymphopoiesis in vivo, physiologically, it contributes to the preservation of very primitive lymphopoietic progenitors, including hematopoietic stem cells, under high estrogen levels
Title: Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5) 1 citation
Gene trapped (1)
Targeted (3) 1 citation
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sfrp5 (e-PCR), detects polymorphism
- UniSTS:471846

Sfrp5 (e-PCR), detects polymorphism
- UniSTS:507221

Sfrp5 (e-PCR), detects polymorphism
- UniSTS:525512

AI605071 (e-PCR)
- UniSTS:181233

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of JUN kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within post-anal tail morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: secreted frizzled-related protein 5

Names: sFRP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018780.3 → NP_061250.2 secreted frizzled-related protein 5 precursor

See identical proteins and their annotated locations for NP_061250.2

Status: VALIDATED

Source sequence(s)

AL603804

Consensus CDS

CCDS29826.1

UniProtKB/Swiss-Prot

Q8K269, Q9WU66

UniProtKB/TrEMBL

A0A0R4J001

Related

ENSMUSP00000018966.8, ENSMUST00000018966.8

Conserved Domains (2) summary

cd07444
Location:44 → 170

CRD_SFRP5; Cysteine-rich domain of the secreted frizzled-related protein 5 (SFRP5), a regulator of Wnt activity

cd03580
Location:175 → 300

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...