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ARL15 ARF like GTPase 15 [ Homo sapiens (human) ]

Gene ID: 54622, updated on 3-Nov-2024

Summary

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Official Symbol
ARL15provided by HGNC
Official Full Name
ARF like GTPase 15provided by HGNC
Primary source
HGNC:HGNC:25945
See related
Ensembl:ENSG00000185305 AllianceGenome:HGNC:25945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARFRP2
Summary
Predicted to enable GTP binding activity and GTPase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 11.3), gall bladder (RPKM 8.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ARL15 in Genome Data Viewer
Location:
5q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (53883942..54310573, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (54711445..55138165, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (53179772..53606403, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16007 Neighboring gene MPRA-validated peak5241 silencer Neighboring gene long intergenic non-protein coding RNA 2105 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:53149739-53150938 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:53157616-53157824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:53178032-53179231 Neighboring gene argininosuccinate synthetase 1 pseudogene 9 Neighboring gene RNA, U6 small nuclear 272, pseudogene Neighboring gene microRNA 581 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:53313399-53314173 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:53314174-53314947 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:53315686-53316592 Neighboring gene RNA, 7SL, cytoplasmic 801, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr5:53476360-53476866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:53592529-53593029 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:53600502-53601165 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1314 Neighboring gene GATA motif-containing MPRA enhancer 36 Neighboring gene long intergenic non-protein coding RNA 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22549 Neighboring gene ribosomal protein L37 pseudogene 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:53735813-53736314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22550 Neighboring gene heat shock protein family B (small) member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application. Saini M, et al. Curr Protein Pept Sci, 2024. PMID 37718516
  2. Association of the ARL15 rs6450176 SNP and serum lipid levels in the Jing and Han populations. Sun JQ, et al. Int J Clin Exp Pathol, 2015. PMID 26722494, Free PMC Article
  3. Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts. Kashyap S, et al. Clin Exp Rheumatol, 2018 Jul-Aug. PMID 29465355
  4. Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis. Sharma A, et al. J Biomol Struct Dyn, 2022 Jul. PMID 33356902
  5. ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs. Zolotarov Y, et al. Cell Mol Life Sci, 2021 Jul. PMID 34089346, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application.
    Title: ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application.
  2. Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer.
    Title: Adenosine diphosphate-ribosylation factor-like 15 can regulate glycolysis and lipogenesis related genes in colon cancer.
  3. Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis.
    Title: Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis.
  4. Magnesium homeostasis is regulated by ARL15 through N-glycosylations of CNNMs.
    Title: ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs.
  5. Correlation between an intronic SNP genotype and ARL15 level in rheumatoid arthritis.
    Title: Correlation between an intronic SNP genotype and ARL15 level in rheumatoid arthritis.
  6. ARL15 plays a role in adipocyte differentiation and adiponectin secretion
    Title: The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
  7. ARL15 expression in rheumatoid arthritis synovial fibroblasts (RASF) play likely role in inflammation and metabolic syndromes through a TNF independent pathway.
    Title: Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts.
  8. The ARL15 and HLA-DMA gene polymorphisms are associated with RA risk in Northwestern Han Chinese population.
    Title: [Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China].
  9. These findings indicated that there may be a racial/ethnic- and/or sex-specific association of the ARL15 rs6450176 single nucleotide polymorphism and serum lipid levels.
    Title: Association of the ARL15 rs6450176 SNP and serum lipid levels in the Jing and Han populations.
  10. The SNPs in ADP-ribosylation factor-like protein 15 (ARL15) and the T-cadherin (CDH13) genes did not exhibit significant association with individual metabolic traits in the T2DM and NDM groups.
    Title: Association study of ARL15 and CDH13 with T2DM in a Han Chinese population.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study reveals ARL15, a novel non-HLA susceptibility gene for rheumatoid arthritis in North Indians.
EBI GWAS Catalog
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 15
Names
ADP ribosylation factor like GTPase 15
ADP-ribosylation factor-like 15
ADP-ribosylation factor-related protein 2
ARF-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019087.3 → NP_061960.1  ADP-ribosylation factor-like protein 15

    See identical proteins and their annotated locations for NP_061960.1

    Status: VALIDATED

    Source sequence(s)
    AC025175, AK000058
    Consensus CDS
    CCDS54850.1
    UniProtKB/Swiss-Prot
    Q6IAD0, Q9NXU5
    UniProtKB/TrEMBL
    A8K4C1
    Related
    ENSP00000433427.1, ENST00000504924.6
    Conserved Domains (1) summary
    cl21455
    Location:34 → 193
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    53883942..54310573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543500.3 → XP_011541802.1  ADP-ribosylation factor-like protein 15 isoform X3

    UniProtKB/TrEMBL
    A8K4C1
    Conserved Domains (2) summary
    cd04162
    Location:53 → 212
    Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
    COG1100
    Location:50 → 174
    Gem1; GTPase SAR1 family domain [General function prediction only]

  2. XM_017009598.2 → XP_016865087.1  ADP-ribosylation factor-like protein 15 isoform X4

    UniProtKB/TrEMBL
    A8K4C1
    Conserved Domains (1) summary
    cd04162
    Location:36 → 195
    Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase

  3. XM_047417335.1 → XP_047273291.1  ADP-ribosylation factor-like protein 15 isoform X4

  4. XM_011543499.3 → XP_011541801.1  ADP-ribosylation factor-like protein 15 isoform X2

    Conserved Domains (2) summary
    cd04162
    Location:76 → 235
    Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
    COG1100
    Location:73 → 197
    Gem1; GTPase SAR1 family domain [General function prediction only]

  5. XM_047417336.1 → XP_047273292.1  ADP-ribosylation factor-like protein 15 isoform X4

  6. XM_011543498.3 → XP_011541800.1  ADP-ribosylation factor-like protein 15 isoform X1

    Conserved Domains (2) summary
    cd04162
    Location:95 → 254
    Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
    COG1100
    Location:92 → 216
    Gem1; GTPase SAR1 family domain [General function prediction only]

  7. XM_047417338.1 → XP_047273294.1  ADP-ribosylation factor-like protein 15 isoform X5

  8. XM_047417340.1 → XP_047273296.1  ADP-ribosylation factor-like protein 15 isoform X7

  9. XM_047417339.1 → XP_047273295.1  ADP-ribosylation factor-like protein 15 isoform X6

    Related
    ENSP00000432680.1, ENST00000507646.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    54711445..55138165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352857.1 → XP_054208832.1  ADP-ribosylation factor-like protein 15 isoform X2

  2. XM_054352858.1 → XP_054208833.1  ADP-ribosylation factor-like protein 15 isoform X3

  3. XM_054352860.1 → XP_054208835.1  ADP-ribosylation factor-like protein 15 isoform X4

  4. XM_054352859.1 → XP_054208834.1  ADP-ribosylation factor-like protein 15 isoform X4

  5. XM_054352856.1 → XP_054208831.1  ADP-ribosylation factor-like protein 15 isoform X1

  6. XM_054352861.1 → XP_054208836.1  ADP-ribosylation factor-like protein 15 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NXU5.1 GenPept UniProtKB/Swiss-Prot:Q9NXU5

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