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Prickle3 prickle planar cell polarity protein 3 [ Mus musculus (house mouse) ]

Gene ID: 54630, updated on 5-Mar-2024

Summary

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Official Symbol
Prickle3provided by MGI
Official Full Name
prickle planar cell polarity protein 3provided by MGI
Primary source
MGI:MGI:1859635
See related
Ensembl:ENSMUSG00000031145 AllianceGenome:MGI:1859635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pk3; Lmo6; Sfc16
Summary
Predicted to enable zinc ion binding activity. Predicted to act upstream of or within cell projection organization. Located in mitochondrion. Is expressed in several structures, including ear; early conceptus; female reproductive system; lower urinary tract; and nervous system. Used to study Leber plus disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy. Orthologous to human PRICKLE3 (prickle planar cell polarity protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 15.2), stomach adult (RPKM 14.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Prickle3 in Genome Data Viewer
Location:
X A1.1; X 3.45 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7523616..7535086)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7657379..7668197)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit Neighboring gene synaptophysin Neighboring gene STARR-positive B cell enhancer ABC_E1215 Neighboring gene predicted gene 14703 Neighboring gene proteolipid protein 2 Neighboring gene MAGI family member, X-linked Neighboring gene peptidylprolyl isomerase A pseudogene x_14.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy. Yu J, et al. J Clin Invest, 2020 Sep 1. PMID 32516135, Free PMC Article
  2. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001
  3. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
  4. Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis. Ru J, et al. Invest Ophthalmol Vis Sci, 2020 Nov 2. PMID 33141892, Free PMC Article
  5. A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. Fu H, et al. J Neurosci, 2009 Sep 9. PMID 19741146, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
    Title: PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prickle planar cell polarity protein 3
Names
LIM domain only protein 6
prickle homolog 3
prickle-like protein 3
triple LIM domain protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290624.2 → NP_001277553.1  prickle planar cell polarity protein 3

    See identical proteins and their annotated locations for NP_001277553.1

    Status: VALIDATED

    Source sequence(s)
    AL672231
    Consensus CDS
    CCDS72329.1
    UniProtKB/Swiss-Prot
    B1AVA9, Q80VL3, Q8CAY9
    UniProtKB/TrEMBL
    Q8CIL5
    Related
    ENSMUSP00000033485.8, ENSMUST00000033485.14
    Conserved Domains (4) summary
    cd09415
    Location:186 → 244
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:249 → 304
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:309 → 367
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:82 → 178
    PET_Prickle; The PET domain of Prickle

RNA

  1. NR_189670.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672231

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7523616..7535086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175097.3: Suppressed sequence

    Description
    NM_175097.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VL3.1 GenPept UniProtKB/Swiss-Prot:Q80VL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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