KIF1A kinesin family member 1A [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF1Aprovided by HGNC
Official Full Name: kinesin family member 1Aprovided by HGNC
Primary source: HGNC:HGNC:888
See related: Ensembl:ENSG00000130294 MIM:601255; AllianceGenome:HGNC:888
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ATSV; MRD9; HSN2C; SPG30; SPG30A; SPG30B; UNC104; C2orf20; NESCAVS
Summary: The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Expression: Biased expression in brain (RPKM 88.6), adrenal (RPKM 8.2) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 2q37.3

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (240713767..240821403, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (241210501..241320366, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (241653184..241760820, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterogeneity of comprehensive clinical phenotype and longitudinal adaptive function and correlation with computational predictions of severity of missense genotypes in KIF1A-associated neurological disorder.
Title: Heterogeneity of comprehensive clinical phenotype and longitudinal adaptive function and correlation with computational predictions of severity of missense genotypes in KIF1A-associated neurological disorder.
KIF1A novel frameshift variant p.(Ser887Profs*64) exhibits clinical heterogeneity in a Pakistani family with hereditary sensory and autonomic neuropathy type IIC.
Title: KIF1A novel frameshift variant p.(Ser887Profs*64) exhibits clinical heterogeneity in a Pakistani family with hereditary sensory and autonomic neuropathy type IIC.
Autosomal dominant neurodevelopmental disorders associated with KIF1A gene variants in 6 pediatric patients.
Title: Autosomal dominant neurodevelopmental disorders associated with KIF1A gene variants in 6 pediatric patients.
[KIF1A gene-associated neurological disease: the correlation between genotype and phenotype].
Title: [KIF1A gene-associated neurological disease: the correlation between genotype and phenotype].
Identification of an in-frame homozygous KIF1A variant causing a mild SPG30 phenotype in a Korean family.
Title: Identification of an in-frame homozygous KIF1A variant causing a mild SPG30 phenotype in a Korean family.
[Analysis of KIF1A gene variant in a Chinese pedigree affected with Spastic paraplegia type 30].
Title: [Analysis of KIF1A gene variant in a Chinese pedigree affected with Spastic paraplegia type 30].
Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder.
Title: Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder.
Investigating KIF1A mutations in a Taiwanese cohort with hereditary spastic paraplegia.
Title: Investigating KIF1A mutations in a Taiwanese cohort with hereditary spastic paraplegia.
De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.
Title: De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors.
KLF5 promotes KIF1A expression through transcriptional repression of microRNA-338 in the development of pediatric neuroblastoma.
Title: KLF5 promotes KIF1A expression through transcriptional repression of microRNA-338 in the development of pediatric neuroblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hereditary spastic paraplegia 30 MedGen: C5235139 OMIM: 610357 GeneReviews: Not available	not available
Intellectual disability, autosomal dominant 9 MedGen: C5393830 OMIM: 614255 GeneReviews: Not available	not available
Neuropathy, hereditary sensory and autonomic, type 2A MedGen: C2752089 OMIM: 201300 GeneReviews: Hereditary Sensory and Autonomic Neuropathy Type II	not available
Neuropathy, hereditary sensory, type 2C MedGen: C3280168 OMIM: 614213 GeneReviews: Hereditary Sensory and Autonomic Neuropathy Type II	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2013-08-08) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2013-08-08) ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	The ability of exogenously expressed FEZ1 binding to kinesin-1 to promote early HIV-1 infection, leading to the movement of HIV-1 CA core to the nucleus	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

KIF1A_8222 (e-PCR)
- UniSTS:467736

G54130 (e-PCR)
- UniSTS:109367

RH47481 (e-PCR)
- UniSTS:64

G31188 (e-PCR)
- UniSTS:181848

G31189 (e-PCR)
- UniSTS:181849

G31190 (e-PCR)
- UniSTS:181850

G42187 (e-PCR)
- UniSTS:105105

D2S140 (e-PCR), detects polymorphism
- UniSTS:49598

D2S140 (e-PCR), detects polymorphism
- UniSTS:65781

A002D44 (e-PCR)
- UniSTS:39674

Clone Names

FLJ30229, MGC133285, MGC133286, DKFZp686I2094

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	TAS Traceable Author Statement more info	PubMed
involved_in anterograde neuronal dense core vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in dense core granule cytoskeletal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde neuronal dense core vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde neuronal dense core vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal dense core vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal dense core vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF1A

Names: axonal transporter of synaptic vesicles; kinesin, heavy chain, member 1A, homolog of mouse; microtubule-based motor KIF1A; unc-104- and KIF1A-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029724.1 RefSeqGene

Range

4900..111444

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_367

mRNA and Protein(s)

NM_001244008.2 → NP_001230937.1 kinesin-like protein KIF1A isoform 1

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS58757.1

UniProtKB/TrEMBL

A0A6Q8PFR5

Related

ENSP00000438388.1, ENST00000498729.9

Conserved Domains (8) summary

smart00129
Location:5 → 361

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1672 → 1774

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1677 → 1770

PH; PH domain

pfam12423
Location:814 → 861

KIF1B; Kinesin protein 1B

pfam12473
Location:1297 → 1397

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
NM_001320705.2 → NP_001307634.1 kinesin-like protein KIF1A isoform 3

Status: REVIEWED

Source sequence(s)

AB210029, AB290172, AC011298, AW246876, BC111780

Consensus CDS

CCDS92991.1

UniProtKB/TrEMBL

A0A3B3IU40, X5D7J0

Related

ENSP00000498196.1, ENST00000648364.1

Conserved Domains (8) summary

smart00129
Location:5 → 361

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1580 → 1682

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1585 → 1678

PH; PH domain

pfam12423
Location:814 → 860

KIF1B; Kinesin protein 1B

pfam12473
Location:1205 → 1305

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
NM_001330289.2 → NP_001317218.1 kinesin-like protein KIF1A isoform 4

Status: REVIEWED

Source sequence(s)

AC011298, AC112784, AK054791, AW246876

Consensus CDS

CCDS92992.1

UniProtKB/TrEMBL

A0A3B3IT28, H7C3Y8

Related

ENSP00000497586.1, ENST00000648680.1

Conserved Domains (8) summary

smart00129
Location:5 → 361

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1589 → 1691

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1594 → 1687

PH; PH domain

pfam12423
Location:814 → 860

KIF1B; Kinesin protein 1B

pfam12473
Location:1205 → 1314

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
NM_001330290.2 → NP_001317219.1 kinesin-like protein KIF1A isoform 5

Status: REVIEWED

Source sequence(s)

AC011298, AC112784, AK054791, AW246876

Consensus CDS

CCDS92993.1

UniProtKB/TrEMBL

A0A3B3ITE5, X5D7J0

Related

ENSP00000497678.1, ENST00000649306.1
NM_001379631.1 → NP_001366560.1 kinesin-like protein KIF1A isoform 6

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

A0A6Q8PFR5
NM_001379632.1 → NP_001366561.1 kinesin-like protein KIF1A isoform 7

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

A0AAQ5BID6

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1664 → 1766

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1233 → 1389

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379633.1 → NP_001366562.1 kinesin-like protein KIF1A isoform 8

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS92990.1

UniProtKB/TrEMBL

A0A3B3ITW6, A0AAQ5BID6

Related

ENSP00000497293.1, ENST00000648129.1
NM_001379634.1 → NP_001366563.1 kinesin-like protein KIF1A isoform 9

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

H7C3Y8
NM_001379635.1 → NP_001366564.1 kinesin-like protein KIF1A isoform 10

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

A0A3B3ITK3, H7C3Y8

Conserved Domains (6) summary

cd00060
Location:526 → 630

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1613 → 1715

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:839 → 885

KIF1B; Kinesin protein 1B

pfam12473
Location:1183 → 1338

DUF3694; Kinesin protein

pfam16183
Location:358 → 549

Kinesin_assoc; Kinesin-associated
NM_001379636.1 → NP_001366565.1 kinesin-like protein KIF1A isoform 11

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS92989.1

UniProtKB/TrEMBL

A0A3B3ITF7, X5D7J0

Related

ENSP00000497739.1, ENST00000647885.1

Conserved Domains (7) summary

cd01233
Location:1609 → 1711

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00769
Location:624 → 678

ERM; Ezrin/radixin/moesin family

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1331

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated

cd22726
Location:491 → 605

FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A
NM_001379637.1 → NP_001366566.1 kinesin-like protein KIF1A isoform 12

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

X5D7J0

Conserved Domains (7) summary

cd01233
Location:1596 → 1698

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00769
Location:649 → 703

ERM; Ezrin/radixin/moesin family

pfam12423
Location:830 → 877

KIF1B; Kinesin protein 1B

pfam12473
Location:1174 → 1318

DUF3694; Kinesin protein

pfam16183
Location:358 → 540

Kinesin_assoc; Kinesin-associated

cd22726
Location:516 → 630

FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A
NM_001379638.1 → NP_001366567.1 kinesin-like protein KIF1A isoform 13

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

H7C3Y8

Conserved Domains (6) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1588 → 1690

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:814 → 860

KIF1B; Kinesin protein 1B

pfam12473
Location:1158 → 1313

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
NM_001379639.1 → NP_001366568.1 kinesin-like protein KIF1A isoform 14

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS92987.1

UniProtKB/TrEMBL

A0A3F2YNW9, X5D7J0

Related

ENSP00000322791.8, ENST00000320389.12

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1579 → 1681

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1304

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379640.1 → NP_001366569.1 kinesin-like protein KIF1A isoform 15

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

X5D7J0

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1570 → 1672

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1148 → 1295

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379641.1 → NP_001366570.1 kinesin-like protein KIF1A isoform 16

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

X5D7J0

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1571 → 1661

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1296

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379642.1 → NP_001366571.1 kinesin-like protein KIF1A isoform 17

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

A0AAQ5BID6

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1672 → 1774

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1241 → 1397

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379645.1 → NP_001366574.1 kinesin-like protein KIF1A isoform 8

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS92990.1

UniProtKB/TrEMBL

A0A3B3ITW6, A0AAQ5BID6

Related

ENSP00000498082.1, ENST00000650130.1
NM_001379646.1 → NP_001366575.1 kinesin-like protein KIF1A isoform 10

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

A0A3B3ITK3, H7C3Y8

Related

ENSP00000497935.2, ENST00000648047.2

Conserved Domains (6) summary

cd00060
Location:526 → 630

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1613 → 1715

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:839 → 885

KIF1B; Kinesin protein 1B

pfam12473
Location:1183 → 1338

DUF3694; Kinesin protein

pfam16183
Location:358 → 549

Kinesin_assoc; Kinesin-associated
NM_001379648.1 → NP_001366577.1 kinesin-like protein KIF1A isoform 19

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

UniProtKB/TrEMBL

H7C3Y8

Conserved Domains (3) summary

cd00060
Location:517 → 621

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1605 → 1707

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
NM_001379649.1 → NP_001366578.1 kinesin-like protein KIF1A isoform 18

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS92988.1

UniProtKB/TrEMBL

A0A3B3IUA1, X5D7J0

Related

ENSP00000498099.1, ENST00000647731.1

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1580 → 1682

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1305

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379650.1 → NP_001366579.1 kinesin-like protein KIF1A isoform 2

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS46561.1

UniProtKB/Swiss-Prot

B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57

UniProtKB/TrEMBL

X5D7J0

Related

ENSP00000497824.1, ENST00000650053.1

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1571 → 1673

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1296

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379651.1 → NP_001366580.1 kinesin-like protein KIF1A isoform 2

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS46561.1

UniProtKB/Swiss-Prot

B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57

UniProtKB/TrEMBL

X5D7J0

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1571 → 1673

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1296

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001379653.1 → NP_001366582.1 kinesin-like protein KIF1A isoform 2

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS46561.1

UniProtKB/Swiss-Prot

B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57

UniProtKB/TrEMBL

X5D7J0

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1571 → 1673

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1296

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_004321.8 → NP_004312.2 kinesin-like protein KIF1A isoform 2

See identical proteins and their annotated locations for NP_004312.2

Status: REVIEWED

Source sequence(s)

AC011298, AC112784

Consensus CDS

CCDS46561.1

UniProtKB/Swiss-Prot

B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57

UniProtKB/TrEMBL

X5D7J0

Related

ENSP00000497030.1, ENST00000649096.1

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1571 → 1673

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1149 → 1296

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated